ChemicalBook > CAS DataBase List > DMT-2'-F-Bz-dA

DMT-2'-F-Bz-dA

Product Name: DMT-2'-F-Bz-dA
CAS No.: 136834-21-4
Chemical Name: DMT-2'-F-Bz-dA
Synonyms: AK-64782;DMT-2'-F-Bz-A;DMT-2'-F-Bz-A;DMT-2'-F-Bz-dA;DMT-2'-F-A(Bz);DMT-2'-F-Bz-dA;DMT-2'-F-dA(Bz);5'-DMT-2'-F-Bz-dA;N6-Bz-DMT-2'-F-dA;5'-O-DMT-2'-F-Bz-dA
CBNumber: CB82610104
Molecular Formula: C38H34FN5O6
Formula Weight: 675.7
MOL File: 136834-21-4.mol

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DMT-2'-F-Bz-dA Property

Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 7.87±0.43(Predicted)
form: Solid
color: White to light yellow
InChIKey: DDOOVEXTSRBCMU-RDDJVILNNA-N
SMILES: O=C(C1C=CC=CC=1)NC1N=CN=C2C=1N=CN2[C@H]1[C@H](F)[C@H](O)[C@@H](COC(C2C=CC=CC=2)(C2C=CC(OC)=CC=2)C2C=CC(OC)=CC=2)O1 |&1:18,19,21,23,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D494273
Product name: 5''-O-DMT-N6-Benzoyl-2''-fluoro-2''-deoxyadenosine
Packaging: 500mg
Price: $240
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NB08366
Product name: N6-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoroadenosine
Packaging: 1g
Price: $220
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NB08366
Product name: N6-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoroadenosine
Packaging: 2g
Price: $380
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NB08366
Product name: N6-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoroadenosine
Packaging: 5G
Price: $750
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NB08366
Product name: N6-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoroadenosine
Packaging: 250mg
Price: $75
Updated: 2021/12/16

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DMT-2'-F-Bz-dA Chemical Properties,Usage,Production

Uses

5''-O-DMT-N6-Benzoyl-2''-fluoro-2''-deoxyadenosine (CAS# 136834-21-4) is a nucleoside building block, used in the preparation of 3'',?4''-?oxetane nucleosides for their anti-viral properties towards Hepatitis C.

Synthesis

40615-36-9

136834-20-3

136834-21-4

N-(9-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide (570 g, 1.53 mol) was dissolved in pyridine (2.85 L, 35.2 mol). The reaction mixture was cooled to 2.6 °C, followed by the addition of 4,4'-bimethoxytrityl chloride (543 g, 1.60 mol). The reaction mixture was stirred at 0 to 5 °C for 2 h and then slowly warmed to room temperature. The progress of the reaction was monitored by LC/MS and after confirming that the reaction was complete, the mixture was cooled below 5°C and the reaction was quenched by slow addition of methanol (124 ml, 3.05 mol) with continuous stirring for 15 min. Subsequently, the reaction mixture was concentrated by co-evaporation with toluene (2.00 L) and diluted with a solvent mixture of ethyl acetate (2.85 L) and n-heptane (2.85 L). The organic layer was washed with 9% saturated aqueous sodium bicarbonate (2.0 L) and ethyl acetate (2.85 L) was added to ensure complete dissolution of the crude product. After stirring for 5 minutes, the organic and aqueous layers were separated. After the organic layer was washed with water (2.0 L), solids began to slowly precipitate out. After separation of the aqueous layer, the organic layer was concentrated to approximately 1/50th of the original volume. the crude product was slurried with a solvent mixture of n-heptane (2.00 L) and toluene (0.50 L), stirred for 15 minutes, and then the light yellow solid was collected by vacuum filtration. The filter cake was washed sequentially with a solvent mixture of (1) n-heptane (0.60 L) and toluene (0.30 L) and (2) n-heptane (3.00 L). The solid was dried at room temperature for 30 min, then transferred to a tray and dried in a vacuum oven at 50 °C overnight to afford the target compound N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide (996.7 g. 1.47 mol, 97% yield).NMR data confirmed the structure of the product.

References

[1] Patent: WO2018/152450, 2018, A1. Location in patent: Page/Page column 61; 62
[2] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 15, p. 4539 - 4543
[3] Patent: WO2018/156625, 2018, A1. Location in patent: Paragraph 0290; 0291
[4] Journal of Medicinal Chemistry, 1993, vol. 36, # 7, p. 831 - 841
[5] Tetrahedron Letters, 1998, vol. 39, # 13, p. 1657 - 1660

DMT-2'-F-Bz-dA Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DMT-2'-F-Bz-dA manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: DMT-2'-F-Bz-dA 136834-21-4
Price: US $0.00-0.00/G
Min. Order: 1G
Purity: 98%
Supply Ability: 2000
Release date: 2025-06-04

Hefei Huana Biomedical Technology Co.,Ltd.

Product: 5'-DMT-2'-F-Bz-dA 136834-21-4
Price: US $0.00/g
Min. Order: 100g
Purity: ≥98%(HPLC)
Supply Ability: 20tons
Release date: 2023-03-29

Zhejiang Hengkang Pharmaceutical Co., Ltd.

Product: DMT-2'-F-Bz-dA 136834-21-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 500kg per month
Release date: 2022-11-25

136834-21-4, DMT-2'-F-Bz-dA Related Search:

Benzoylmetronildazole

N6-benzoyl-2'-deoxy-2'-fluoro-5'-O-(4,4'-dimethoxytrityl)adenosine

N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoroadenosine

Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-deoxy-2'-fluoro-

N6-Benzoyl-5'-O-DMT-2'-fluoro-2'-deoxyadenosine

AK-64782

5'-DMT-2'-F-Bz-dA

DMT-2'-F-BZ-DA N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

5'-O-DMT-N6-Bz-2'-F-dA

Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-deoxy-2'-fluoro- ISO 9001：2015 REACH

5'-O-DMT-2'-Fluoro-N6-Benzoyl-2'-deoxyadenosine

5'-O-DMT-2'-F-Benzoyl-Deoxyadenosine

N-[9-[(2R,3R,4R,5R)-5-[[Bis(4-methoxyphenyl)(phenyl)methoxy]methyl]-3-fluoro-4-hydroxy-2-tetrahydrofuryl]-9H-purin-6-yl]benzamide

5'-ODMT-2'-Fluoro-N-Bz Adenosine

DMT-2'-F-dA(Bz)

DMT-2'-F-Bz-dA

DMT-2'-F-Bz-A

5'-O-DMT-N6-benzoyl-2'-fluoro-2'-deoxyadenosine

5'-O-DMT-2'-F-N6-Bz-deoxyadenosine

N6-Bz-DMT-2'-F-dA

N6-Bz-2'-F-5'-O-DMT-2'-dA

5'-O-DMTr-2'-F-dA(Bz)

N6-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoroadenosine

DMT-2'-F-A(Bz)

DMT-2'-F-Bz-dA

5'-O-DMT-2'-F-Bz-dA

DMT-2'-F-Bz-A

N6-Benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-Fluoro-2'-Deoxyadenosine

5'-O-DMT-N6-BENZOYL-2'-FLUORO-2'-DEOXYADENOSINE

5’-O-DMT-2'-F-dA(bz)

N6-Bz-5'-O-DMT-2'-F-dA N6-Benzoyl-5'-O-(4,4’-dimethoxytrityl)-2'-fluoro-2'-deoxy-adenosine

136834-21-4

Modified（deoxy）nucleoside