ChemicalBook > CAS DataBase List > (Z)-Methyl 2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d] iMidazole-4-carboxylate

(Z)-Methyl 2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d] iMidazole-4-carboxylate

Product Name
(Z)-Methyl 2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d] iMidazole-4-carboxylate
CAS No.
147403-65-4
Chemical Name
(Z)-Methyl 2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d] iMidazole-4-carboxylate
Synonyms
QC-8897;Azilsartan-20;Azilsartan impurity T;Azilsartan impurity07;Azilsartan Impurity 19;Azilsartan Impurity 46;Azilsartan intermediates;InterMediate of Azilsartan;Azilsartan N-Hydroxy Methyl Ester;Intermediate of Azilsartan Medoxomil
CBNumber
CB82611217
Molecular Formula
C25H24N4O4
Formula Weight
444.48
MOL File
147403-65-4.mol
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(Z)-Methyl 2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d] iMidazole-4-carboxylate Property

Melting point:
207-209℃
Boiling point:
657.2±65.0 °C(Predicted)
Density 
1.29
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
6.77±0.69(Predicted)
color 
White to Pale Yellow
InChI
InChI=1S/C25H24N4O4/c1-3-33-25-27-22-10-6-9-21(24(30)32-2)23(22)29(25)16-17-11-13-18(14-12-17)20-8-5-4-7-19(20)15-26-28-31/h4-15,28,31H,3,16H2,1-2H3
InChIKey
STYVDYYCTQZFDE-UHFFFAOYSA-N
SMILES
C1(OCC)N(CC2=CC=C(C3=CC=CC=C3C=NNO)C=C2)C2=C(C(OC)=O)C=CC=C2N=1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
E892030
Product name
2-Ethoxy-1-[[2''-[(hydroxyamino)iminomethyl][1,1''-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylicAcidMethylEster
Packaging
250mg
Price
$340
Updated
2021/12/16
AK Scientific
Product number
7328AA
Product name
Methyl2-ethoxy-1-((2'-(N-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
Packaging
250mg
Price
$92
Updated
2021/12/16
AK Scientific
Product number
7328AA
Product name
Methyl2-ethoxy-1-((2'-(N-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
Packaging
1g
Price
$142
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0392942
Product name
METHYL-2-ETHOXY-1-((2'-(N-HYDROXYCARBAMIMIDOYL)-[1,1'-BIPHENYL]-4-YL)METHYL)-1H-BENZO[D]IMIDAZOLE-7-CARBOXYLATE
Purity
95.00%
Packaging
5MG
Price
$504.11
Updated
2021/12/16
Matrix Scientific
Product number
095147
Product name
Methyl 2-ethoxy-1-((2'-(N-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
Purity
95+%
Packaging
250mg
Price
$756
Updated
2021/12/16
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(Z)-Methyl 2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d] iMidazole-4-carboxylate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Azilsartan (A926900) derivative. Intermediate in the synthesis of angiotensin II receptor antagonist.

Synthesis

139481-44-0

147403-65-4

N,N-dimethylacetamide (2 L) and water (16 L) were added to the reaction flask, followed by hydroxylamine hydrochloride (3.37 kg, 48.6 mol) and sodium carbonate (5.15 kg, 48.6 mol). Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate (2 kg, 4.86 mol) was added to the reaction mixture and the reaction was carried out at 70 °C for 18 hours. After completion of the reaction, it was cooled to room temperature and water (2 L) was added to promote precipitation of the product. The precipitate was collected by filtration to afford methyl 2-ethoxy-1-[2'-(N'-hydroxyformamidino)biphenyl-4-yl]-1H-benzimidazole-7-carboxylate (1.94 kg, 37.70 mol). The product was analyzed by HPLC (refer to Example 1 conditions) with 98.9% purity and 90% yield.

References

[1] Patent: CN103408500, 2016, B. Location in patent: Paragraph 0026; 0046-0047
[2] Patent: WO2013/114305, 2013, A1. Location in patent: Page/Page column 15; 16
[3] Organic Process Research and Development, 2015, vol. 19, # 4, p. 514 - 519
[4] Organic Process Research and Development, 2013, vol. 17, # 1, p. 77 - 86
[5] Journal of Heterocyclic Chemistry, 2013, vol. 50, # 4, p. 929 - 936

(Z)-Methyl 2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d] iMidazole-4-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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(Z)-Methyl 2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d] iMidazole-4-carboxylate Suppliers

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View Lastest Price from (Z)-Methyl 2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d] iMidazole-4-carboxylate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2-Ethoxy-1-[[2'-[(hydroxyamino)iminomethyl][1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid methyl ester 147403-65-4
Price
US $2.00-5.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-19
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Intermediate of Azilsartan Medoxomil 147403-65-4
Price
US $0.00-0.00/Kg/Bag
Min. Order
100g
Purity
98%min
Supply Ability
700kg/month
Release date
2021-06-11
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Azilsartan impurity S 147403-65-4
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-06-03

147403-65-4, (Z)-Methyl 2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d] iMidazole-4-carboxylateRelated Search:

Azilsartan Medoxomil Azilsartan Azilsartan iMpurity A Azilsartan Impurity 7 1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, Methyl ester Azilsartan Impurity 1-[(2'-carbaMoylbiphenyl-4-yl) Methyl]-2-ethoxybenziMidazole-7-carboxylic acid 1-((2'-cyanobiphenyl-4-yl)Methyl)-2-ethoxy-1H-benziMidazole-7-carboxylic acid Azilsartan Impurity Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate O-Desethyl Azilsartan Ethyl-3-Amino-2-[(2'-Cyanoiphenyl-4-yl) Methyl]-Amino Benzoate Azilsartan Impurity (Z)-2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-carboxylic acid Azilsartan Impurity (Z)-Methyl 3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-2-oxo-2,3-dihydro-1H-benzo[d]iMidazole-4-carboxylate 1-[[2'-(AMinoiMinoMethyl)[1,1'-biphenyl]-4-yl]Methyl]-2-ethoxy-1H-benziMidazole-7-carboxylic Acid Azilsartan iMpurity I

  • (Z)-Methyl 2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d] iMidazole-4-carboxylate
  • (Z)-Methyl 2-ethoxy-1-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-1H-benzo[d]iMidazole-7-carboxylate
  • (Z)-Methyl 2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d] iMidazole-4-ca
  • Methyl 2-ethoxy-1-((2'-(N-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole
  • InterMediate of Azilsartan
  • Methyl 2-Ethoxy-1-[[2'-(hydroxyamidino)biphenyl-4-yl]-1H-benzimidazole-7-carbo-xylate
  • methyl (Z)-2-ethoxy-1-((2'-(N'-hydroxycar bamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
  • 2-Ethoxy-1-｛[2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl]Methyl｝-1H-benzo[d]iMidazole-7 -carboxylic acid Methyl ester
  • Azilsartan Impurity 19
  • methyl 2-ethoxy-3-[[4-[2-[(Z)-N'-hydroxycarbamimidoyl]phenyl]phenyl]methyl]benzimidazole-4-carboxylate
  • Methyl 2-ethoxy-1-((2'-(N-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidaz
  • Azilsartan impurity T
  • 2-Ethoxy-1-[[2'-[(hydroxyamino)iminomethyl][1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-
  • Azilsartan intermediates
  • 1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid methyl ester
  • 2-Ethoxy-1-[[2'-[(hydroxyamino)iminomethyl][1
  • (Z)-methyl 2-ethoxy-1-((2'-(N'-hydroxycarbamimidoyl)-
  • Azilsartan impurity 21/Methyl 2-ethoxy-1-((2'-(N-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
  • Azilsartan-20
  • 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-[(hydroxyamino)iminomethyl][1,1'-biphenyl]-4-yl]methyl]-, methyl ester
  • Methyl-2-Ethoxy-1-[[2'-Hydroxycarbamimidoyl)Biphenyl)-4-yl]-Methyl-1H-Benzimidazole-7-Carboxylate
  • Methyl (Z)-2-ethoxy-1-((2'-(N'-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-indole-7-carboxylate
  • Intermediate of Azilsartan Medoxomil
  • 2-Ethoxy-[[2’-(hydroxyamidino) biphenyl-4-yl)methyl]-1-H-benzimidazole-7carboxylate
  • Azilsartan Impurity 46
  • Methyl 2-Ethoxy-1-[[2’-(hydroxyamidino)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate
  • 2-ethoxy-1-((2'-((hydroxyamino)iminomethyl)(1,1'-biphenyl)-4...
  • 2-Ethoxy-1-[[2a€-[(hydroxyamino)iminomethyl][1,1a€-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid Methyl Ester
  • Methyl 2-Ethoxy-3-[2'-(N-hydroxycarbamimidoyl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid
  • (Z)-Methyl2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)Chemicalbookbiphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-carboxylate
  • QC-8897
  • Azilsartan N-Hydroxy Methyl Ester
  • (Z)-methyl 2-ethoxy-1-((2'-(N'-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
  • Methyl 2-ethoxy-1-((2'-(N-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
  • 2-Ethoxy-1-[[2'-[(hydroxyamino)iminomethyl][1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid methyl ester
  • Methyl(Z)-2-ethoxy-1-((2'-(N'-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-indole-7-carboxylate
  • methyl (Z)-2-ethoxy-1-((2'-(N'-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
  • Azilsartan impurity07
  • methyl 2-ethoxy-1-{[2'-(N-hydroxycarbamimidoyl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate
  • 1-[(2'-(Hydroxyamidino)[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylicacidmethylester
  • Methyl2-ethoxy-1-[[2'-[(hydroxyamino)iminomethyl][1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate
  • 2-Ethoxy-1-[[2′-[(hydroxyamino)iminomethyl][1,1′-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid Methyl Ester, CAS 147403-65-4
  • 2-ethoxy-1-((2'-((hydroxyamino)iminomethyl)(1,1'-biphenyl)-4-yl)methyl)-1h-benzimidazole-7-carboxylic acid methyl ester
  • 147403-65-4
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals