ChemicalBook > CAS DataBase List > Propanoic acid, 3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(diMethylaMino)-3-oxopropyl]thio]Methyl]thio]-, sodiuM salt, (E)-

Propanoic acid, 3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(diMethylaMino)-3-oxopropyl]thio]Methyl]thio]-, sodiuM salt, (E)-

Product Name
Propanoic acid, 3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(diMethylaMino)-3-oxopropyl]thio]Methyl]thio]-, sodiuM salt, (E)-
CAS No.
115103-85-0
Chemical Name
Propanoic acid, 3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(diMethylaMino)-3-oxopropyl]thio]Methyl]thio]-, sodiuM salt, (E)-
Synonyms
711;L-660;MK-571 Sodium;Verlukast sodium;MK-571 sodium saL;MK-571 SODIUM HYDRATE;MK-571 Sodium (L-660711);MK-571 sodium salt hydrate;L-660;711;MK571;MK 571;L660711;L-660711;5-(3-(2-(7-Chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acid sodium salt hydrate
CBNumber
CB82614258
Molecular Formula
C26H28ClN2NaO3S2
Formula Weight
539.08
MOL File
115103-85-0.mol
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Propanoic acid, 3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(diMethylaMino)-3-oxopropyl]thio]Methyl]thio]-, sodiuM salt, (E)- Property

storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
H2O: soluble15mg/mL, clear
form 
powder
color 
white to beige
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M7571
Product name
MK-571 sodium salt hydrate
Purity
≥95% (HPLC)
Packaging
5mg
Price
$149
Updated
2024/03/01
Sigma-Aldrich
Product number
M7571
Product name
MK-571 sodium salt hydrate
Purity
≥95% (HPLC)
Packaging
25mg
Price
$587
Updated
2024/03/01
Cayman Chemical
Product number
70720
Product name
MK-571 (sodium salt)
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
70720
Product name
MK-571 (sodium salt)
Purity
≥95%
Packaging
5mg
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
70720
Product name
MK-571 (sodium salt)
Purity
≥95%
Packaging
10mg
Price
$109
Updated
2024/03/01
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Propanoic acid, 3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(diMethylaMino)-3-oxopropyl]thio]Methyl]thio]-, sodiuM salt, (E)- Chemical Properties,Usage,Production

Uses

MK-571 sodium salt hydrate has been used:

  • as an efflux inhibitor for monitoring multidrug resistance protein (MRP)-function and to avoid redundancy of other transporters
  • to assess its effect on cell proliferation and 2D-migration in vitro in various cell lines of glioblastoma multiforme (GBM)
  • as multidrug resistance (MDR) transporter inhibitor to study its effects in ovarian cancer cells
  • as specific inhibitors of ABCC1/2 to investigate transport, toxicity, flow cytometry and arsenic efflux

Biological Activity

mk571 sodium salt is a specific cyslt1 (cysteinyl-leukotriene type 1 receptor) antagonist [1].cysteinyl leukotriene receptor 1, also termed as cysltr1, is a receptor for cysteinyl leukotrienes (lt)which mediates a large variety of allergic and hypersensitivity reactions in humans [2].

Biochem/physiol Actions

MK 571 is a potent and selective leukotriene D4 (LTD4) antagonist and ABCC multidrug resistance protein 1(MRP1) inhibitor. The cysteinyl leukotrienes (CysLTs), LTC4, LTD4, and LTE4, mediate their actions through two distinct G-protein coupled receptors. LTD4 is the preferred ligand for the CysLT1 receptor, whereas LTC4 and LTD4 bind with approximately equal affinity to the CysLT2 receptor. MK 571 is a selective, orally active CysLT1 receptor antagonist. It blocks the binding of LTD4, but not LTC4, to human and guinea pig lung membranes with Ki values of 0.22 nM and 2.1 nM, respectively. MK 571 effectively blocks LTD4 activation of recombinant human and mouse CysLT1 receptors but is ineffective at blocking LTC4 or LTD4 activation of the recombinant human or murine CysLT2 receptors. It potentially inhibits MRP1 and has been shown to overcome acquired arsenic tolerance.

in vitro

mk571 is a multidrug resistance protein-2 (abcc2, mrp2) inhibitor and had been widely used to demonstrate the role of mrp2 in the cellular efflux of drugs, xenobiotics and their conjugates. apically-applied mk571 resulted in significant reductions in both the apical and basolateral efflux of flavonol conjugates from caco-2/tc7 monolayers. the estimated ki for inhibition of the synthesis of k-4′-o-glca by mk571 is 19.7 μm. mk571 inhibited the intracellular biosynthesis of all flavonol glucuronides and sulphates by caco-2 cells in a dose-dependent manner. mk571 significantly inhibited phase-2 conjugation of kaempferol by cell-free extracts of caco-2, and competitively inhibited the production of kaempferol-4′-o-glucuronide. these data indicated that mk571, in addition to inhibiting mrp2, was a potential inhibitor of enterocyte phase-2 conjugation [3].

storage

+4°C

References

[1]. thivierge m, turcotte s, rola-pleszczynski m, et al. enhanced cysteinyl-leukotriene type 1 receptor expression in t cells from house dust mite-allergic individuals following stimulation with der p[j]. journal of immunology research, 2015, 2015.
[2]. singh rk, tandon r, dastidar sg, ray a (november 2013). "a review on leukotrienes and their receptors with reference to asthma". the journal of asthma. 50 (9): 922–31.
[3]. barrington r d, needs p w, williamson g, et al. mk571 inhibits phase-2 conjugation of flavonols by caco-2/tc7 cells, but does not specifically inhibit their apical efflux[j]. biochemical pharmacology, 2015, 95(3): 193-200.

Propanoic acid, 3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(diMethylaMino)-3-oxopropyl]thio]Methyl]thio]-, sodiuM salt, (E)- Preparation Products And Raw materials

Raw materials

Preparation Products

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Propanoic acid, 3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(diMethylaMino)-3-oxopropyl]thio]Methyl]thio]-, sodiuM salt, (E)- Suppliers

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115103-85-0, Propanoic acid, 3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(diMethylaMino)-3-oxopropyl]thio]Methyl]thio]-, sodiuM salt, (E)-Related Search:


  • MK-571 SODIUM HYDRATE
  • Propanoic acid, 3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(diMethylaMino)-3-oxopropyl]thio]Methyl]thio]-, sodiuM salt, (E)-
  • 5-(3-(2-(7-Chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acid sodium salt hydrate
  • MK-571 sodium salt hydrate
  • (E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propanoic acid sodium salt
  • MK-571 Sodium
  • Verlukast sodium
  • L-660;711;MK571;MK 571;L660711;L-660711;L-660711 SODIUM SALT;MK571 SODIUM SALT;MK 571 SODIUM SALT;L660711 SODIUM SALT;L 660711 SODIUM SALT;MK-571 SODIUM SALT
  • 711
  • L-660
  • L-660;711;MK571;MK 571;L660711;L-660711
  • MK-571 sodium saL
  • MK-571 Sodium (L-660711)
  • Sodium (E)-3-(((3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)((3-(dimethylamino)-3-oxopropyl)thio)methyl)thio)propanoate
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  • 115103-85-0
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  • C26H26ClN2NaO3S2xH2O