ethyl 5-broMo-6-Methylnicotinate
- Product Name
- ethyl 5-broMo-6-Methylnicotinate
- CAS No.
- 1190862-70-4
- Chemical Name
- ethyl 5-broMo-6-Methylnicotinate
- Synonyms
- ethyl 5-broMo-6-Methylnicotinate;5-BroMo-6-Methyl-nicotinic acid ethyl ester;5-Bromo-6-methyl-3-pyridinecarboxylic acid ethyl ester;3-Pyridinecarboxylic acid, 5-broMo-6-Methyl-, ethyl ester
- CBNumber
- CB82614470
- Molecular Formula
- C9H10BrNO2
- Formula Weight
- 244.09
- MOL File
- 1190862-70-4.mol
ethyl 5-broMo-6-Methylnicotinate Property
- Boiling point:
- 270.5±35.0 °C(Predicted)
- Density
- 1.439±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 1.66±0.20(Predicted)
N-Bromosuccinimide Price
- Product number
- E901075
- Product name
- Ethyl5-Bromo-6-methylnicotinate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- E901075
- Product name
- Ethyl5-Bromo-6-methylnicotinate
- Packaging
- 100mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 4098AJ
- Product name
- Ethyl5-bromo-6-methylnicotinate
- Packaging
- 250mg
- Price
- $238
- Updated
- 2021/12/16
- Product number
- HCH0371127
- Product name
- ETHYL-5-BROMO-6-METHYLNICOTINATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.07
- Updated
- 2021/12/16
- Product number
- 69R0819
- Product name
- 5-Bromo-6-methyl-nicotinicacidethylester
- Purity
- 95%
- Packaging
- 5g
- Price
- $1198
- Updated
- 2021/12/16
ethyl 5-broMo-6-Methylnicotinate Chemical Properties,Usage,Production
Synthesis
13061-96-6
1190862-68-0
1190862-70-4
To an oven-dried resealable Schlenk tube, ethyl 5,6-dibromonicotinate (1.09 g, 3.5 mmol), methylboronic acid (0.24 g, 4.0 mmol), potassium carbonate (1.46 g, 10.6 mmol), and 1,4-dioxane (27 mL) were added sequentially. Three evacuation-argon backfill cycles were performed on the Schlenk tubes, followed by the addition of tetrakis(triphenylphosphine)palladium(0) (0.41 g, 0.35 mmol). After three more evacuation-argon backfill cycles, the Schlenk tube was sealed and the reaction mixture was placed in an oil bath and the reaction was stirred at 110 °C. After 3 days of reaction, the mixture was cooled and filtered through Celite. The filtrate was concentrated under reduced pressure and the residue was purified by fast column chromatography (eluent ratio: 97:3 to 9:1 hexane/ethyl acetate) to afford the target product ethyl 5-bromo-6-methylnicotinate (0.41 g, 45% yield) as a solid.LRMS (m/z): 244/246 (M + 1)+.1H-NMR δ (CDCl3): 1.41 (t, J = 9.0 Hz, 3H), 2.74 (s, 3H), 4.41 (q, J = 9.0 Hz, 2H), 8.40 (d, J = 3.0 Hz, 1H), 9.01 (d, J = 3.0 Hz, 1H).
References
[1] Patent: EP2108641, 2009, A1. Location in patent: Page/Page column 55-56
ethyl 5-broMo-6-Methylnicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
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