GAP 27

ChemicalBook > CAS DataBase List > GAP 27

Product Name: GAP 27
CAS No.: 198284-64-9
Chemical Name: GAP 27
Synonyms: GAP 27;Gap 27（TFA);GAP 27, >98%;GAP-27; GAP27;SRPTEKTIFIIRPTEKTIFII;M.W. 1304.55 C60H101N15O17;Gap 27, gap junction blocking peptide;Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile;Gap 27，Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile;Gap 27,Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile, >98%
CBNumber: CB8261625
Molecular Formula: C60H101N15O17
Formula Weight: 1304.53
MOL File: 198284-64-9.mol

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GAP 27 Property

Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: Soluble at 1mg/ml in 1% acetic acid
pka: 3.41±0.10(Predicted)
form: Solid
color: White to off-white
Water Solubility: Soluble to 1 mg/ml in water
Sequence: H-Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile-OH

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G1794
Product name: GAP 27
Purity: ≥97% (HPLC)
Packaging: 2mg
Price: $179.6
Updated: 2024/03/01

Alfa Aesar

Product number: J64109
Product name: GAP 27
Packaging: 0.5mg
Price: $70.9
Updated: 2023/06/20

Alfa Aesar

Product number: J64109
Product name: GAP 27
Packaging: 1mg
Price: $110
Updated: 2023/06/20

Tocris

Product number: 1476
Product name: GAP 27
Packaging: 1
Price: $259
Updated: 2021/12/16

TRC

Product number: G245230
Product name: GAP 27
Packaging: 2.5mg
Price: $385
Updated: 2021/12/16

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GAP 27 Chemical Properties,Usage,Production

Uses

Gap27 is a connexin (Cx) mimetic peptide that inhibits connexin-mediated communication (CMC). In vitro, Gap27 has been shown to improve cell migration during scrape-wound repair in hyperglycemia/hyperinsulinemia conditions. It also reduces acetylcholine-induced hyperpolarization in smooth muscle cells.

Biological Activity

gap 27 is a peptide(ser-arg-pro-thr-glu-lys-thr-ile-phe-ile-ile) derived from connexin 43 that is a selective gap junction blocker.connexins, or gap junctions, are a family of structurally-related transmembrane proteins. gap junctions contain channels that allow the passage of ions and small molecules between adjacent cells. this intercellular communication has been implicated in the coordination of cellular responses to intracellular signaling molecules. calcium and inositol phosphates are among the second messengers that can pass through gap junction channels. this synthetic connexin-mimetic peptide, gap 27, was used to evaluate the contribution of gap-junctional communication to osteoclastic bone resorption. it was concluded that gap-junctional communication is necessary for proper bone remodeling.figure1 formula of gap 27

storage

Store at -20°C

References

1. Berthoud, V. et al. Am. J. Physiol. Lung Cell Mol. Physiol. 279, 619 (2000)2. Ilvesaro, J. et al. BMC Musculoskel. Disord. 2, 10 (2001)3. Chaytor, A. et al. Brit. J. Pharmacol. 144, 108 (2005)4. Boitano, S. and H. Evans Am. J. Physio.l Lung Cell Mol. Physiol. 279, L623 ( 2000).

GAP 27 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from GAP 27 manufacturers

Career Henan Chemical Co

Product: GAP 27 198284-64-9
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-13

198284-64-9, GAP 27Related Search:

H-ILE-ILE-OH GAP 27

H-SER-ARG-PRO-THR-GLU-LYS-THR-ILE-PHE-ILE-ILE-OHSER-ARG-PRO-THR-GLU-LYS-THR-ILE-PHE-ILE-ILE

GAP 27

GAP-27; GAP27

M.W. 1304.55 C60H101N15O17

Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile

GAP 27, >98%

Gap 27,Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile, >98%

L-Isoleucine, L-seryl-L-arginyl-L-prolyl-L-threonyl-L-α-glutamyl-L-lysyl-L-threonyl-L-isoleucyl-L-phenylalanyl-L-isoleucyl-

Gap27,inhibit,Inhibitor,Gap-27,Gap 27,Gap Junction Protein

Gap 27，Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile

SRPTEKTIFIIRPTEKTIFII

Gap 27（TFA)

Gap 27, gap junction blocking peptide

198284-64-9

C60H102N15O17

C60H101N15O17

Cytoskeleton and Extracellular Matrix

Cell Signaling and Neuroscience

Cell Biology

BioChemical

Adhesion Molecules and Related Proteins

Cell Signaling and Neuroscience

Cytoskeleton and Extracellular Matrix

Various Peptides

Neuroscience