AST-1306
- Product Name
- AST-1306
- CAS No.
- 897383-62-9
- Chemical Name
- AST-1306
- Synonyms
- CS-590;ALS 1306;AST-1306;Allitinib;Allitinib (AST1306);N-(4-(4-(3-fluorobenzyloxy)-3-chlorophenylamino)quinazolin-6-yl)acrylamide;N-[4-[[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]amino]quinazolin-6-yl]acrylamide;N-[4-[[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]-2-propenamide;2-Propenamide, N-[4-[[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]-;anilino-quinazoline,Inhibitor,anti-cancer,Epidermal growth factor receptor,ALS1306,Allitinib,Irreversible,HER1,inhibit,AST1306,AST 1306,ALS-1306,ErbB-1,EGFR
- CBNumber
- CB82620006
- Molecular Formula
- C24H18ClFN4O2
- Formula Weight
- 448.88
- MOL File
- 897383-62-9.mol
AST-1306 Property
- Boiling point:
- 655℃
- Density
- 1.395
- Flash point:
- 350℃
- storage temp.
- Store at -20°C
- solubility
- ≥22.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- form
- solid
- pka
- 12.16±0.43(Predicted)
N-Bromosuccinimide Price
- Product number
- A790045
- Product name
- AST-1306
- Packaging
- 200mg
- Price
- $2470
- Updated
- 2021/12/16
- Product number
- 143801
- Product name
- N-(4-(3-Chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)acrylamide
- Purity
- 95%
- Packaging
- 100mg
- Price
- $3108
- Updated
- 2021/12/16
- Product number
- orb181197
- Product name
- AST-1306
- Purity
- >98%
- Packaging
- 1000mg
- Price
- $4469.3
- Updated
- 2021/12/16
- Product number
- 143801
- Product name
- N-(4-(3-Chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)acrylamide
- Purity
- 95%
- Packaging
- 1g
- Price
- $7178
- Updated
- 2021/12/16
- Product number
- 2230AH
- Product name
- N-[4-[[3-Chloro-4-[(3-fluorophenyl)-methoxy]-phenyl]-amino]-6-quinazolinyl]-2-propenamide
- Packaging
- 1g
- Price
- $9740
- Updated
- 2021/12/16
AST-1306 Chemical Properties,Usage,Production
Uses
AST-1306 is a novel irreversible inhibitor of EGFR and ErbB4 with IC50 of 0.5 nM and 0.8 nM, respectively.
Uses
AST-1306 is a selective irreversible inhibitor of the epidermal growth factor receptor (EGFR) 1 and 2. Studies show that AST-1306 inhibited the enzymatic activities of wild-type EGF) and ErbB2 as well as EGFR resistant mutant in both cell-free and cell-based systems. AST-1306 was more effective in inhibiting tumors with ErbB2-overexpressing cells than EGFR-overexpressing tumor.
Definition
ChEBI: N-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]-6-quinazolinyl]-2-propenamide is a member of quinazolines.
Biological Activity
ast1306 is a novel inhibitor of egfr and her2 (ic50 = 0.5 nm and 3 nm respectively)egfr (epidermal growth factor receptor) is a cell-surface receptor tyrosine kinase. the receptor activation leads to dimerization and tyrosine autophosphorylation. it induces a cascade of downstream cellular responses such as modification in gene expression, cell proliferation and cytoskeletal rearrangement etc. her2 is a member of the epidermal growth factor and is associated with breast and ovarian cancers.ast1306 selectively blocked egfr and her2 kinase activities in a cell-free assay. the tyrosine kinase activity of egfr mutant t790m/l858r was also inhibited by ast1306 in intact cell and cell-free assays. in addition, ast1306 attenuated the egfr and her2 phosphorylation and downstream substrates. [1]in erbb2-overexpressing xenograft and fvb-2/nneu transgenic mouse model, ast1306 potently inhibited tumor growth. in sk-ov-3 xenograft model, ast1306 caused a quick and long-lasting (≥24h) inhibition of egfr and her2. [1]
References
1. xie h, lin l, tong l et al. ast1306, a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, exhibits antitumor activity both in vitro and in vivo. plos one. 2011;6(7):e21487.
AST-1306 Preparation Products And Raw materials
Raw materials
Preparation Products
AST-1306 Suppliers
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View Lastest Price from AST-1306 manufacturers
- Product
- AST-1306 897383-62-9
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-12