ChemicalBook > CAS DataBase List > OC000459

OC000459

Product Name
OC000459
CAS No.
851723-84-7
Chemical Name
OC000459
Synonyms
1H-Indole-1-acetic acid, 5-fluoro-2-methyl-3-(2-quinolinylmethyl)-;OC-459;CS-581;OC000495;OC000459;OC000459, >=98%;OC000459 USP/EP/BP;OC000459(Timapiprant);Timapiprant (OC000459);Timapiprant, 10 mM in DMSO
CBNumber
CB82620011
Molecular Formula
C21H17FN2O2
Formula Weight
348.37
MOL File
851723-84-7.mol
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OC000459 Property

Boiling point:
574.4±50.0 °C(Predicted)
Density 
1.29
storage temp. 
Store at -20°C
solubility 
DMF: 0.5 mg/ml; DMSO: 1.1 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
form 
A crystalline solid
pka
4.08±0.10(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H303May be harmfulif swallowed

H320Causes eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
12027
Product name
OC000459
Purity
≥98%
Packaging
5mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
12027
Product name
OC000459
Purity
≥98%
Packaging
10mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
12027
Product name
OC000459
Purity
≥98%
Packaging
25mg
Price
$235
Updated
2024/03/01
TRC
Product number
O135000
Product name
OC000459
Packaging
10mg
Price
$165
Updated
2021/12/16
ChemScene
Product number
CS-1285
Product name
Timapiprant
Purity
98.52%
Packaging
10mg
Price
$120
Updated
2021/12/16
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OC000459 Chemical Properties,Usage,Production

Uses

OC000459 is a CRTH2 antagonist which helps in the treatment of allergies, reducing nasal and ocular symptoms in subjects exposed to allergens.

in vivo

Timapiprant (OC000459) (gavage; 2 mg/kg, 10 mg/kg) inhibits blood eosinophilia induced by 13,14-dihydro-15-keto-PGD2 (DK-PGD2) in Rat (ED50=0.04 mg/kg)[1]. Timapiprant (OC000459) (gavage; 0.01 mg/kg, 0.1 mg/kg, 1.0 mg/kg) inhibits airway eosinophilia in response to an aerosol of DK-PGD2 in guinea pigs (ED50=0.01 mg/kg)[1].

IC 50

DP

OC000459 Preparation Products And Raw materials

Raw materials

Preparation Products

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OC000459 Suppliers

Canada 1 China 123 United Kingdom 1 United States 18 Global 143
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
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View Lastest Price from OC000459 manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
OC000459 851723-84-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98
Supply Ability
10000KGS
Release date
2025-11-24
Wuhan Nutra Biotechnology Co.,Ltd
Product
OC000459 851723-84-7
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%+
Supply Ability
100kgs
Release date
2021-05-26
Dingwang Technology (Wuhan) Co., Ltd.
Product
OC000459 851723-84-7
Price
US $0.00/mg
Min. Order
100mg
Purity
99%
Supply Ability
50-100kg
Release date
2023-02-06

851723-84-7, OC000459Related Search:


  • OC000459
  • 2-(5-fluoro-2-Methyl-3-(quinolin- 2-ylMethyl)-1H-indol-1-yl)acetic acid
  • 5-Fluoro-2-Methyl-3-quinolin-2-ylMethylindo-1-yl)-acetic(OC000459)
  • [5-Fluoro-2-methyl-3-(quinolin-2-ylmethyl)indol-1-yl]acetic acid
  • 5-Fluoro-2-methyl-3-(2-quinolinylmethyl)-1H-indole-1-acetic acid
  • OC000495
  • (5-Fluoro-3-isoquinolin-3-ylMethyl-2-Methyl-indol-1-yl)-acetic acid
  • 1H-Indole-1-acetic acid, 5-fluoro-2-methyl-3-(2-quinolinylmethyl)-
  • [5-Fluoro-2-methyl-3-(quinolin-2-ylmethyl)indol-1-yl]acetic acid OC000459
  • OC-459
  • OC000459;OC-000459; OC 000459
  • OC000459, >=98%
  • CS-581
  • OC000459(Timapiprant)
  • 2-[5-FLUORO-2-METHYL-3-(QUINOLIN-2-YLMETHYL)INDOL-1-YL]ACETIC ACID
  • OC000459 USP/EP/BP
  • Timapiprant (OC000459)
  • Timapiprant, 10 mM in DMSO
  • [5-Fluoro-2-methyl-3-(2-quinolinylmethyl)-1H-indol-1-yl]acetic acid
  • 851723-84-7
  • 51723-84-7
  • Inhibitors