TP 235
- Product Name
- TP 235
- CAS No.
- 443104-02-7
- Chemical Name
- TP 235
- Synonyms
- TP 235;CPD1598;RTA 403;CDDO-IM;CDDO IMidazolide;CDDO-Im (RTA-403);CDDO-Im, 10 mM in DMSO;CDDO-Im, RTA 403, TP 235;CDDO-Imidazolide, RTA-403, TP-235;CDDO imidazolide, Fatty acid synthesis inhibitor
- CBNumber
- CB82620884
- Molecular Formula
- C34H43N3O3
- Formula Weight
- 541.72
- MOL File
- 443104-02-7.mol
TP 235 Property
- Melting point:
- >164°C (dec.)
- Boiling point:
- 681.8±65.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Very Slightly, Heated)
- form
- Solid
- pka
- 3.47±0.10(Predicted)
- color
- Pale Yellow to Very Dark Yellow
- Stability:
- Light Sensitive
N-Bromosuccinimide Price
- Product number
- SML3452
- Product name
- CDDO-Im
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $129
- Updated
- 2023/01/07
- Product number
- SML3452
- Product name
- CDDO-Im
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $519
- Updated
- 2023/01/07
- Product number
- 4737
- Product name
- CDDOIm
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $233
- Updated
- 2021/12/16
- Product number
- 254913
- Product name
- CDDO Im
- Packaging
- 10mg
- Price
- $489
- Updated
- 2021/12/16
- Product number
- 005840
- Product name
- CDDO Imidazolide
- Packaging
- 1mg
- Price
- $744
- Updated
- 2021/12/16
TP 235 Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Solid
Uses
CDDO Imidozolide (CDDO-Im) is a synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells. Studies show that CDDO-Im is highly active in suppressing cellular proliferation of human leukemia and breast cancer cell lines as well as being an effective therapeutic agent in the treatment of other types of cancers.
Biological Activity
CDDO-Im is a bifunctional CDDO analog th at enhances NRF2-mediated antioxidant and anti-inflammatory activity by forming not only KEAP1 covalent adducts (Michael adducts via cysteines, acyl adducts via lysines and tyrosines) in the same manner as CDDO and CDDO-Me, but also by covalently transacylating arginine and serine residues in GSTP and cross-linking them to adjacent cysteine residues. CDDO-Im is typically used in the range of 1-40 nM in cultures, 2-5.5 mg/kg via i.p. and 2.5 mg/kg via i.v. in vivo (mice and rats).
storage
Store at RT
TP 235 Preparation Products And Raw materials
Raw materials
Preparation Products
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