TP 235

Product Name: TP 235
CAS No.: 443104-02-7
Chemical Name: TP 235
Synonyms: TP 235;CPD1598;RTA 403;CDDO-IM;CDDO IMidazolide;CDDO-Im (RTA-403);CDDO-Im, 10 mM in DMSO;CDDO-Im, RTA 403, TP 235;CDDO-Imidazolide, RTA-403, TP-235;CDDO imidazolide, Fatty acid synthesis inhibitor
CBNumber: CB82620884
Molecular Formula: C34H43N3O3
Formula Weight: 541.72
MOL File: 443104-02-7.mol

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TP 235 Property

Melting point:: >164°C (dec.)
Boiling point:: 681.8±65.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Very Slightly, Heated)
form: Solid
pka: 3.47±0.10(Predicted)
color: Pale Yellow to Very Dark Yellow
Stability:: Light Sensitive
InChIKey: ITFBYYCNYVFPKD-FMIDTUQUSA-N
SMILES: [n]6(cncc6)C(=O)[C@]21[C@H]([C@@H]3[C@]([C@@]4(CC[C@@H]5[C@@](C4=CC3=O)(C=C(C(=O)C5(C)C)C#N)C)C)(CC2)C)CC(CC1)(C)C

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3452
Product name: CDDO-Im
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $153
Updated: 2026/03/19

Sigma-Aldrich

Product number: SML3452
Product name: CDDO-Im
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $469
Updated: 2026/03/19

Tocris

Product number: 4737
Product name: CDDOIm
Purity: ≥98%(HPLC)
Packaging: 10
Price: $233
Updated: 2021/12/16

TRC

Product number: C228090
Product name: CDDOImidazolide
Packaging: 10mg
Price: $2775
Updated: 2021/12/16

Usbiological

Product number: 254913
Product name: CDDO Im
Packaging: 10mg
Price: $489
Updated: 2021/12/16

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TP 235 Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

CDDO Imidozolide (CDDO-Im) is a synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells. Studies show that CDDO-Im is highly active in suppressing cellular proliferation of human leukemia and breast cancer cell lines as well as being an effective therapeutic agent in the treatment of other types of cancers.

Biological Activity

CDDO-Im is a bifunctional CDDO analog th at enhances NRF2-mediated antioxidant and anti-inflammatory activity by forming not only KEAP1 covalent adducts (Michael adducts via cysteines, acyl adducts via lysines and tyrosines) in the same manner as CDDO and CDDO-Me, but also by covalently transacylating arginine and serine residues in GSTP and cross-linking them to adjacent cysteine residues. CDDO-Im is typically used in the range of 1-40 nM in cultures, 2-5.5 mg/kg via i.p. and 2.5 mg/kg via i.v. in vivo (mice and rats).

in vivo

CDDO-Im is a potent inhibitor of de novo inducible nitric oxide synthase expression in primary mouse macrophages. Moreover, CDDO-Im inhibits growth of B16 murine melanoma and L1210 murine leukemia cells in vivo. Injection of 10 nM (5.4 μg) of CDDO-Im almost completely blocks the ability of IFN-γ to induce iNOS, and treatment with as little as 1 nmol of CDDO-Im (0.54 μg) is partially effective^[1].

IC 50

PPARα: 232 nM (Ki); PPARγ: 344 nM (Ki); Nrf2

storage

Store at RT

TP 235 Preparation Products And Raw materials

Raw materials

Preparation Products

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TP 235 Suppliers

Canada 1 China 77 India 1 United Kingdom 1 United States 11 Global 91

J & K SCIENTIFIC LTD.

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Haoyuan Chemexpress Co., Ltd.

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MedChemexpress LLC

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ShangHai Caerulum Pharma Discovery Co., Ltd.

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Bide Pharmatech Ltd.

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Finetech Industry Limited

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Shanghai Lollane Biological Technology Co.,Ltd.

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SPIRO PHARMA

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443104-02-7, TP 235Related Search:

1-(2-Cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-1H-iMidazole

2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid iMidazolide

CDDO IMidazolide

CDDO-IM

RTA 403

TP 235

CDDO-Im (RTA-403)

CDDO-Im, RTA 403, TP 235

CPD1598

(4aR,6aR,6aS,6bR,8aS,12aS,14bS)-8a-(imidazole-1-carbonyl)-4,4,6a,6b,11,11,14b-heptamethyl-3,13-dioxo-4a,5,6,6a,7,8,9,10,12,12a-decahydropicene-2-carbonitrile

1H-Imidazole, 1-(2-cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-

(4aR,6aS,6bR,8aS,12aS,12bR,14bS)-8a-(1H-Imidazole-1-carbonyl)-4,4,6a,6b,11,11,14b-heptamethyl-3,13-dioxo-3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-2-carbonitrile

inhibit,Ferroptosis,Keap1-Nrf2,CDDO Im,Inhibitor,CDDO-Im,Peroxisome proliferator-activated receptors,TP235,RTA 403,CDDOIm,RTA403,TP 235,PPAR

CDDO-Imidazolide, RTA-403, TP-235

CDDO imidazolide, Fatty acid synthesis inhibitor

CDDO-Im, 10 mM in DMSO

443104-02-7