PF5081090
- Product Name
- PF5081090
- CAS No.
- 1312473-63-4
- Chemical Name
- PF5081090
- Synonyms
- PF-5081090;PF 05081090;PF 05081090 - PF 5081090;(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1-yl]-N-hydroxy-2-methyl-2-methylsulfonylbutanamide;(αR)-4-(2-Fluoro-4-Methoxyphenyl)-N-hydroxy-α-Methyl-α-(Methylsulfonyl)-2-oxo-1(2H)-pyridinebutanaMide;1(2H)-Pyridinebutanamide, 4-(2-fluoro-4-methoxyphenyl)-N-hydroxy-α-methyl-α-(methylsulfonyl)-2-oxo-, (αR)-;(2R)-4-[4-(2-Fluoro-4-methoxyphenyl)-2-oxo-2H-pyridin-1-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide;(R)-4-(4-(4-(2H-1,2,3-triazol-2-yl)phenyl)-2-oxopyridin-1(2H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide
- CBNumber
- CB82621977
- Molecular Formula
- C18H21FN2O6S
- Formula Weight
- 412.43
- MOL File
- 1312473-63-4.mol
PF5081090 Property
- Melting point:
- >175°C (dec.)
- Density
- 1.378±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: >5mg/mL (warmed)
- pka
- 8.11±0.50(Predicted)
- form
- powder
- color
- white to beige
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- Axon 2113
- Product name
- PF 05081090 - PF 5081090
- Purity
- 98%
- Packaging
- 5mg
- Price
- $104
- Updated
- 2021/12/16
- Product number
- Axon 2113
- Product name
- PF 05081090 - PF 5081090
- Purity
- 98%
- Packaging
- 2x5mg
- Price
- $154
- Updated
- 2021/12/16
- Product number
- INB0001529
- Product name
- PF-5081090
- Purity
- 98.00%
- Packaging
- 5MG
- Price
- $257.4
- Updated
- 2021/12/16
- Product number
- B5563
- Product name
- (R)-4-(4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide
- Packaging
- 10mg
- Price
- $347
- Updated
- 2021/12/16
- Product number
- Axon 2113
- Product name
- PF 05081090 - PF 5081090
- Purity
- 98%
- Packaging
- 25mg
- Price
- $357
- Updated
- 2021/12/16
PF5081090 Chemical Properties,Usage,Production
Chemical Properties
Pale Beige Solid
Uses
PF-5081090 is a pyridone methylsulfone hydroxamate LpxC inhibitor. PF-5081090 is used as an antibiotic in the treatment of serious gram-negative infections.
in vivo
PF-5081090 (8.75, 75, 300 mg/kg; s.c.; single dose) exhibits a exposure increasing in linear manner across the dose range in mice, with area under the concentration-time curve (AUC) and maximum concentration of drug in serum (Cmax) increasing with a proportional increase in dose[1].
PF-5081090 shows potent efficacies against sentinel strains of P. aeruginosa and K. pneumonia in CD-1 mice, with effective dose (ED50) ranging from 7.4-55.9 mg/kg (against acute septicemia model), <25 mg/kg (against pneumonia model), and 16.8 mg/kg (against neutropenic thigh model) in mice infected with P. aeruginosa PA-1950[1].
Pharmacokinetics of PF-5081090 in CD-1 micea[1]
| Dose (mg/kg) | Cmax (mg/L) | Tmax (h) | AUC (h mg/L) | Free AUC (h mg/L) | T1/2 (h) | CL (L/h/kg) | Vss (L/kg) |
| 18.75 | 5.02 | 0.25 | 5.09 | 1.58 | 0.6 | 3.79 | 2.20 |
| 75 | 15.50 | 0.33 | 17.60 | 5.46 | 0.69 | 4.32 | 3.30 |
| 300 | 75.40 | 0.33 | 76.30 | 23.70 | 0.68 | 3.92 | 2.53 |
PF5081090 Preparation Products And Raw materials
Raw materials
Preparation Products
PF5081090 Suppliers
- Tel
- --
- Fax
- --
- info@trc-canada.com
- Country
- Canada
- ProdList
- 6038
- Advantage
- 71
View Lastest Price from PF5081090 manufacturers
- Product
- PF5081090 1312473-63-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200g
- Release date
- 2020-02-01