BAY 61-3606 (dihydrochloride)
- Product Name
- BAY 61-3606 (dihydrochloride)
- CAS No.
- 648903-57-5
- Chemical Name
- BAY 61-3606 (dihydrochloride)
- Synonyms
- BAY 61-3606(HCl);BAY-61-3606 ，S7006;BAY 61-3606 (dihydrochloride);BAY61-3606; BAY-61-3606; BAY-613606;BAY61-3606 DIHYDROCHLORIDE;BAY 61-3606;BAY 61-3606 dihydrochloride, 10 mM in DMSO;BAY 61-3606 dihydrochloride (BAY61-3606 dihydrochloride;2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide dihydrochloride;BAY 613606 dihydrochloride,Spleen tyrosine kinase,inhibit,Syk,Inhibitor,Apoptosis,BAY 61 3606 dihydrochloride
- CBNumber
- CB82624079
- Molecular Formula
- C20H20Cl2N6O3
- Formula Weight
- 463.3172
- MOL File
- 648903-57-5.mol
BAY 61-3606 (dihydrochloride) Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : 7.14 mg/mL (15.41 mM; Need ultrasonic)
- form
- Yellow solid.
- color
- Off-white to yellow
N-Bromosuccinimide Price
- Product number
- A3228
- Product name
- BAY61-3606dihydrochloride
- Packaging
- 5mg
- Price
- $221
- Updated
- 2021/12/16
- Product number
- CS-0234
- Product name
- BAY61-3606dihydrochloride
- Purity
- 98.76%
- Packaging
- 10mg
- Price
- $312
- Updated
- 2021/12/16
- Product number
- A3228
- Product name
- BAY61-3606dihydrochloride
- Packaging
- 10mg
- Price
- $378
- Updated
- 2021/12/16
- Product number
- KIN0002596
- Product name
- BAY 61 3606 DIHYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $392.7
- Updated
- 2021/12/16
- Product number
- A3228
- Product name
- BAY61-3606dihydrochloride
- Packaging
- 2mg
- Price
- $147
- Updated
- 2021/12/16
BAY 61-3606 (dihydrochloride) Chemical Properties,Usage,Production
Uses
BAY 61-3606 dihydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM an IC50 of 10 nM[1]. BAY 61-3606 dihydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell[2]. BAY 61-3606 dihydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates[3]. Bay 61-3606 dihydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells[4].
in vivo
Bay 61-3606 (50 mg/kg; administered twice a week for two weeks by intraperitoneal injection) alone leads to more efficacious reductions than that of TNF-related apoptosis-inducing ligand (TRAIL; 10 mg/kg) alone in MCF-7 tumor xenograft-bearing BALB/c nude mice. Bay 61-3606 administered in TRAIL combination significantly reduces the volume of the xenografted tumor[4].
| Animal Model: | Female BALB/c nude mice (5 weeks old) bearing MCF-7 tumor xenograft[4] |
| Dosage: | 50 mg/kg |
| Administration: | Injected intraperitoneally twice a week with Bay 61–3606 (50 mg/kg), TRAIL (10 mg/kg) or a combination of Bay 61-3606 (50 mg/kg) and TRAIL (10 mg/kg); TRAIL was given 2 h after the injection of Bay 61-3606; for two weeks |
| Result: | Led to efficacious reductions in tumor growth. |
References
[1] Yamamoto N, et al. The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents. J Pharmacol Exp Ther. 2003 Sep;306(3):1174-81. DOI:10.1124/jpet.103.052316
[2] Tümmler C, et al. SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells in Vitro. Cancers (Basel). 2019 Feb 10;11(2). pii: E202. DOI:10.3390/cancers11020202
[3] Gioia R, et al. Quantitative phosphoproteomics revealed interplay between Syk and Lyn in the resistance to AMN107 in chronic myeloid leukemia cells. Blood. 2011 Aug 25;118(8):2211-21. DOI:10.1182/blood-2010-10-313692
[4] Kim SY, et al. Bay 61-3606 Sensitizes TRAIL-Induced Apoptosis by Downregulating Mcl-1 in Breast Cancer Cells. PLoS One. 2015 Dec 31;10(12):e0146073. DOI:10.1371/journal.pone.0146073
BAY 61-3606 (dihydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
BAY 61-3606 (dihydrochloride) Suppliers
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 12952
- Advantage
- 65
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
- ProdList
- 4861
- Advantage
- 58
- Tel
- +1 (866) 930-6790
- Fax
- +1 (866) 333-9607
- info@adooq.com
- Country
- United States
- ProdList
- 2782
- Advantage
- 58
- Tel
- 021-61995394 18916691159
- chemicalsea@163.com
- Country
- China
- ProdList
- 1972
- Advantage
- 58
- Tel
- 18149758185 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3505
- Advantage
- 58
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2990
- Advantage
- 60
- Tel
- +86-21-5821 5861
- Fax
- +86-21-5106 2861
- sales@letopharm.com
- Country
- China
- ProdList
- 2384
- Advantage
- 58
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4827
- Advantage
- 55
- Tel
- Fax
- -
- eric_feng1954@126.com
- Country
- China
- ProdList
- 9248
- Advantage
- 55