BIX02189

ChemicalBook > CAS DataBase List > BIX02189

Product Name: BIX02189
CAS No.: 1265916-41-3
Chemical Name: BIX02189
Synonyms: BIX02189（d）;BIX02189 (BIX 02189);(Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-c;(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide;1H-Indole-6-carboxamide, 3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-, (3Z)-;Mitogen-activated protein kinase kinase,inhibit,MAP2K,MAPKK,MEK,BIX02189,Extracellular signal regulated kinases,Inhibitor,ERK,BIX-02189
CBNumber: CB82624099
Molecular Formula: C27H28N4O2
Formula Weight: 440.54
MOL File: 1265916-41-3.mol

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BIX02189 Property

Boiling point:: 653.4±55.0 °C(Predicted)
Density: 1.230±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMSO:34.48(Max Conc. mg/mL);78.27(Max Conc. mM)
DMF:15.0(Max Conc. mg/mL);34.05(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.13(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);22.7(Max Conc. mM)
form: A crystalline solid
pka: 11.61±0.20(Predicted)
color: White to yellow

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Safety

HS Code: 2933790090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H335May cause respiratory irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16999
Product name: BIX02189
Purity: ≥98%
Packaging: 5mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 16999
Product name: BIX02189
Purity: ≥98%
Packaging: 10mg
Price: $210
Updated: 2024/03/01

Cayman Chemical

Product number: 16999
Product name: BIX02189
Purity: ≥98%
Packaging: 25mg
Price: $290
Updated: 2024/03/01

Cayman Chemical

Product number: 16999
Product name: BIX02189
Purity: ≥98%
Packaging: 50mg
Price: $760
Updated: 2021/12/16

TRC

Product number: B591765
Product name: BIX02189
Packaging: 10mg
Price: $250
Updated: 2021/12/16

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BIX02189 Chemical Properties,Usage,Production

Uses

BIX 02189 inhibits TGF-b1-induced lung cancer cell metastasis by directly targeting TGF-b type I receptor.

Definition

ChEBI: 3-[[3-[(dimethylamino)methyl]anilino]-phenylmethylidene]-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide is an indolecarboxamide.

Enzyme inhibitor

This selective MEK/ERK pathway inhibitor (FW = 440.54 g/mol; CAS 1265916-41-3; Solubility: 100 mM in DMSO; 100 mM for monohydrochloride salt), also named (3Z)-3-[[[3-[(dimethylamino) methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo- 1H-indole-6-carboxamide, targets Mitogen/Extracellular signal-regulated Kinase-5, or MEK5 (IC50 = 1.5 nM), and Extracellular-signal-Regulated Kinase, or ERK5 (IC50 = 59 nM), showing far weaker effects on MEK1 (IC50 = 6200 nM), MEK2 (IC50 = >6200 nM), ERK1 (IC50 >6200 nM), JNK2 (IC50 >6200 nM), TGFβR1 (IC50 = 580 nM), EGFR (IC50 >6300 nM), and STK16 (IC50 >6300 nM). Pharmacology: ERK5 is an atypical MAPK that is activated in the heart by pressure overload. ERK5 regulates cardiac hypertrophy and hypertrophy-induced apoptosis, and silencing ERK5 expression or inhibiting its kinase activity with BIX02189 reduces Myocyte Enhancer Factor-2 (MEF2) transcriptional activity and blunted hypertrophic responses in neonatal rat cardiomyocytes, or NRCMs. By applying BIX02189 to NRCMs, ERK5 phosphorylation is blocked without affecting other MAP kinases. BIX02189 induces apoptosis in acute myeloid leukemia tumor cells without affecting T cells from healthy donors

storage

Store at -20°C

BIX02189 Preparation Products And Raw materials

Raw materials

Preparation Products

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BIX02189 Suppliers

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1265916-41-3, BIX02189Related Search:

(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide

(Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-c

BIX02189 (BIX 02189)

1H-Indole-6-carboxamide, 3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-, (3Z)-

Mitogen-activated protein kinase kinase,inhibit,MAP2K,MAPKK,MEK,BIX02189,Extracellular signal regulated kinases,Inhibitor,ERK,BIX-02189

BIX02189（d）

1265916-41-3

MAPK