SLx-2119

ChemicalBook > CAS DataBase List > SLx-2119

Product Name: SLx-2119
CAS No.: 911417-87-3
Chemical Name: SLx-2119
Synonyms: belumosudil;KD-025;SLx2119;CS-1555;SLx 2119;SLx-2119;Rezurock;SLx-2119(KD-025);KD025 (SLx-2119);ROCK inhibitor 2
CBNumber: CB82624291
Molecular Formula: C26H24N6O2
Formula Weight: 452.51
MOL File: 911417-87-3.mol

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SLx-2119 Property

Melting point:: >228oC (dec.)
Boiling point:: 682.6±55.0 °C(Predicted)
Density: 1.318±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: Soluble in DMSO (25 mg/ml)
pka: 13?+-.0.40(Predicted)
form: solid
color: White
Stability:: Stable for 1 year as supplied from date of purchase. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17055
Product name: KD025
Purity: ≥98%
Packaging: 50mg
Price: $236
Updated: 2024/03/01

Cayman Chemical

Product number: 17055
Product name: KD025
Purity: ≥98%
Packaging: 100mg
Price: $413
Updated: 2024/03/01

Cayman Chemical

Product number: 17055
Product name: KD 025
Purity: ≥98%
Packaging: 1mg
Price: $49
Updated: 2021/12/16

Cayman Chemical

Product number: 17055
Product name: KD 025
Purity: ≥98%
Packaging: 5mg
Price: $221
Updated: 2021/12/16

Cayman Chemical

Product number: 17055
Product name: KD 025
Purity: ≥98%
Packaging: 10mg
Price: $59
Updated: 2024/03/01

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SLx-2119 Chemical Properties,Usage,Production

Description

KD 025 is an inhibitor of Rho-associated kinase 2 (ROCK2; IC₅₀ = 0.105 μM). It is selective for ROCK2 over ROCK1 (IC₅₀ = 24 μM). KD 025 (10 μM) decreases the expression of connective tissue growth factor (CTGF) and induces remodeling of the actin cytoskeleton in isolated human ileal fibrotic smooth muscle cells. It inhibits heat-killed C. albicans- or S. epidermidis-induced production of IL-17 in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 1.25 to 10 μM. KD 025 (100 and 200 mg/kg) reduces infarct volume in a mouse model of cerebral ischemia induced by transient middle cerebral artery occlusion (MCAO). It decreases disease severity in a mouse model of sclerodermatous chronic graft versus host disease (GVHD) when administered at a dose of 150 mg/kg. Formulations containing KD 025 have been used in the treatment of chronic GVHD.

Uses

KD 025 is an inhibitor of Rho-associated protein kinase II (ROCK-II), a serine/threonine kinase that regulates the formation of actin stress fibers and focal adhesions, smooth muscle contraction, and gene expression (1, 2). KD025 has been shown to reduce infarct volume after transient middle cerebral artery occlusion (2).

brand name

Rezurock

General Description

Class: serine-threonine kinase; Treatment: chronic GVHD; Other name: SLx-2119, KD025; Oral bioavailability = 64%; Elimination half-life = 19 h; Protein binding = 99.9%

target

Primary target: ROCK2

References

Boerma et al. (2008) Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin; Blood Coagul. Fibrinolysis.?19 709 Zanin-Zhorov et al. (2014) Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism; Natl. Acad. Sci. USA?111 16814 Flynn et al. (2016) Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism; 127 2144 Jagasia et al. (2021) ROCK2 Inhibition with Belumosudil (KD025) for the Treatment of Chronic Graft-Versus-Host Disease; Clin. Invest.?39 1888 Diep et al. (2018) Anti-adipogenic effects of KD025 (SLx-2119), a ROCK2-specific inhibitor, in 3T3-L1 cells; Rep.?8 2477 Diep et al. (2019) KD025 (SLx-2119) suppresses adipogenesis at intermediate stage in human adipose-derived stem cells; Adipocyte?9 114 Wei et al. (2020) ROCK2 inhibition enhances the thermogenic program in white and brown fat tissue in mice; FASEB J.?34 474 Tran and Chun (2021) ROCK2-Specific Inhibitor KD025 Suppresses Adipocyte Differentiation by Inhibiting Casein Kinase 2; Molecules?26 4747

SLx-2119 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from SLx-2119 manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: SLx-2119 911417-87-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-29

911417-87-3, SLx-2119Related Search:

Dequalinium chloride BI 2536 Ibrutinib Volasertib (BI 6727) FLUSULFAMIDE

ROCK INHIBITOR;SLX-2119

ROCK inhibitor 2

KD-025

SLx 2119

SLx2119

SLx-2119

2-[3-[4-[(1H-Indazol-5-yl)amino]quinazolin-2-yl]phenoxy]-N-isopropylacetamide

KD025 (SLx-2119)

SLx-2119(KD-025)

KD025 (SLX-2119);SLX 2119;SLX2119

2-(3-(4-((2H-indazol-5-yl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide

SLX 2119; SLX2119;KD-025

SLX2119(KD025);SLX 2119(KD 025);SLX2119;KD025

ROCK inhibitor 2/ KD025.slx-2119

SLx-2119 (ROCK inhibitor

CS-1555

2-[3-[4-(1h-indazol-5-ylamino)quinazolin-2-yl]phenoxy]-n-propan-2-ylacetamide

Acetamide, 2-[3-[4-(1H-indazol-5-ylamino)-2-quinazolinyl]phenoxy]-N-(1-methylethyl)-

Belumosudil(KD-025)

belumosudil

Belumosudil (SLx-2119)

SLx-2119(KD-025,Belumosudil )

Belumosudil (KD025, SLx-2119)

Rezurock

2-[3-[4-(1H-Indazol-5-ylamino)-2-quinazolinyl]phenoxy]-N-(1-methylethyl)acetamide

inhibit,Rho-kinase,KD-025,Rho-associated protein kinase,ROCK2,KD 025,Belumosudil,Anti-fibrotic,SLx 2119,ROK,ROCK,SLx2119,Rho-associated kinase,Inhibitor

Azvudine Impurity 19

2- [3- [4- [(1H-indazol-5-yl) amino] Quinazoline -2-yl] phenoxy] - N-isopropylacetamide

SLX2119 SLX-2119

2-[3-[4-[(5-Indazolyl)amino]-2-quinazolinyl]phenoxy]-N-isopropylacetamide

13C6]-Belumosudil

911417-87-3

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