Quinoline, 7-broMo-4-Methyl-
- Product Name
- Quinoline, 7-broMo-4-Methyl-
- CAS No.
- 141052-31-5
- Chemical Name
- Quinoline, 7-broMo-4-Methyl-
- Synonyms
- CAS:141052-31-5;4-Methyl-7-broMoquinoline;4-Methyl-7-broMoquinazoline;Quinoline, 7-broMo-4-Methyl-
- CBNumber
- CB82624862
- Molecular Formula
- C10H8BrN
- Formula Weight
- 222.08
- MOL File
- 141052-31-5.mol
Quinoline, 7-broMo-4-Methyl- Property
- Boiling point:
- 315.8±22.0 °C(Predicted)
- Density
- 1.488±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.08±0.27(Predicted)
- Appearance
- Brown to gray Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FB141892
- Product name
- 7-Bromo-4-methylquinoline
- Packaging
- 50mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- Z4153
- Product name
- 7-Bromo-4-methylquinoline
- Packaging
- 250mg
- Price
- $158
- Updated
- 2021/12/16
- Product number
- FB141892
- Product name
- 7-Bromo-4-methylquinoline
- Packaging
- 100mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- FB141892
- Product name
- 7-Bromo-4-methylquinoline
- Packaging
- 250mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- FB141892
- Product name
- 7-Bromo-4-methylquinoline
- Packaging
- 500mg
- Price
- $350
- Updated
- 2021/12/16
Quinoline, 7-broMo-4-Methyl- Chemical Properties,Usage,Production
Synthesis
78-94-4
141052-31-5
Concentrated sulfuric acid (14.4 mL, 270 mmol) was slowly added to a 1,4-dioxane (1 L) solution of 3-bromoaniline (30.0 g, 174 mmol) at room temperature. The reaction mixture was heated to reflux and a 1,4-dioxane (50 mL) solution of methyl vinyl ketone (19.5 mL, 270 mmol) was added dropwise over 3 hours. After the dropwise addition, the reflux reaction was continued for 1 hour. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in water (100 mL), neutralized with sodium carbonate to neutral, and subsequently extracted with dichloromethane. The organic phases were combined, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated and the resulting crude product was purified by silica gel column chromatography (Biotage system, eluent 20% ethyl acetate/hexane) to afford 4-methyl-7-bromoquinoline (15.0 g, 43% yield) as a brown solid.1H NMR (CDCl3) δ: 8.80-8.75 (m, 1H), 8.30 (s, 1H), 7.90-7.85 (m , 1H), 7.70-7.65 (m, 1H), 7.25-7.20 (m, 1H), 2.65 (s, 3H).
References
[1] Patent: WO2004/48383, 2004, A1. Location in patent: Page 40-41
Quinoline, 7-broMo-4-Methyl- Preparation Products And Raw materials
Raw materials
Preparation Products
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