BAY-57-1293

ChemicalBook > CAS DataBase List > BAY-57-1293

Product Name: BAY-57-1293
CAS No.: 348086-71-5
Chemical Name: BAY-57-1293
Synonyms: Pritelivir;N-Methyl-N-(4-methyl-5-sulfamoylthiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide;AIC316;CS-857;BAY-57-1293;Pritelivir base;PRITELIVIR;AIC316;BAY571293(Pritelivir);Pritelivir,BAY-57-1293;PRITELIVIR; BAY-57-1293; AIC316
CBNumber: CB82627368
Molecular Formula: C18H18N4O3S2
Formula Weight: 402.49
MOL File: 348086-71-5.mol

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BAY-57-1293 Property

Boiling point:: 639.4±65.0 °C(Predicted)
Density: 1.396±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: insoluble in H2O; insoluble in EtOH; ≥13.9 mg/mL in DMSO
form: solid
pka: 9.31±0.60(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22129
Product name: BAY 57-1293
Purity: ≥98%
Packaging: 5mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 22129
Product name: BAY 57-1293
Purity: ≥98%
Packaging: 50mg
Price: $160
Updated: 2024/03/01

Cayman Chemical

Product number: 22129
Product name: BAY 57-1293
Purity: ≥98%
Packaging: 1mg
Price: $25
Updated: 2021/12/16

Cayman Chemical

Product number: 22129
Product name: BAY 57-1293
Purity: ≥98%
Packaging: 10mg
Price: $56
Updated: 2024/03/01

Cayman Chemical

Product number: 22129
Product name: BAY 57-1293
Purity: ≥98%
Packaging: 25mg
Price: $112
Updated: 2024/03/01

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BAY-57-1293 Chemical Properties,Usage,Production

Uses

BAY 57-1293 is a potent inhibitor of herpes simplex virus (HSV) that target the virus helicase primase complex.

Biological Activity

bay 57-1293 is a potent and safe inhibitor of hsv helicase-primase with ic50 value of 12nm [1].bay 57-1293 displays anti-herpes activity through inhibiting the helicase-primase and affecting the viral dna synthesis. in the in vitro viral replication assay, bay 57-1293 shows inhibition against hsv-1 f, hsv-2 g and acyclovir-resistant hsv-1 f mutant with ic50 value of 20nm. in the plaque reduction assay and the conventional cytopathogenicity assay, bay 57-1293 shows ic50 values of 0.01-0.02μm and 0.01-0.03μm, respectively. besides that, bay 57-1293 is active at an ic50 value of 10nm–30nm against all clinical isolates of hsv-1 and hsv-2. furthermore, bay 57-1293 is active in vivo. the oral administration of bay 57-1293 shows 10-fold more potent than valacyclovir in a murine model of disseminated herpes infection. in a rat lethal challenge model, bay 57-1293 exerts profound antiviral activity without toxic effects. [1, 2]

storage

Store at -20°C

References

[1] kleymann g, fischer r, betz u a k, et al. new helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease. nature medicine, 2002, 8(4): 392-398.
[2] betz u a k, fischer r, kleymann g, et al. potent in vivo antiviral activity of the herpes simplex virus primase-helicase inhibitor bay 57-1293. antimicrobial agents and chemotherapy, 2002, 46(6): 1766-1772.

BAY-57-1293 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BAY-57-1293 manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: BAY-57-1293 348086-71-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

Career Henan Chemical Co

Product: BAY-57-1293 348086-71-5
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-07-09

348086-71-5, BAY-57-1293Related Search:

PRITELIVIR;AIC316

Benzeneacetamide, N-[5-(aminosulfonyl)-4-methyl-2-thiazolyl]-N-methyl-4-(2-pyridinyl)-

AIC316

N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide BAY57-1293 Pritelivir

2-METHYL-2-PROPANYL [4-(CHLOROSULFONYL)PHENYL]CARBAMATE

BAY571293(Pritelivir)

BAY-57-1293

Pritelivir

N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide

Pritelivir,BAY-57-1293

BAY 57-1293 - Pritelivir | AIC 316

CS-857

PRITELIVIR; BAY-57-1293; AIC316

N-methyl-N-(4-methyl-5-sulfamoyl-1,3-thiazol-2-yl)-2-(4-pyridin-2-ylphenyl)acetamide

N-Methyl-N-(4-methyl-5-sulfamoylthiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide

N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-(4-pyridin-2-ylphenyl)acetamide

Pritelivir base

348086-71-5

Inhibitors