ChemicalBook > CAS DataBase List > BAY-57-1293

BAY-57-1293

Product Name
BAY-57-1293
CAS No.
348086-71-5
Chemical Name
BAY-57-1293
Synonyms
Pritelivir;N-Methyl-N-(4-methyl-5-sulfamoylthiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide;AIC316;CS-857;BAY-57-1293;Pritelivir base;PRITELIVIR;AIC316;BAY571293(Pritelivir);Pritelivir,BAY-57-1293;PRITELIVIR; BAY-57-1293; AIC316
CBNumber
CB82627368
Molecular Formula
C18H18N4O3S2
Formula Weight
402.49
MOL File
348086-71-5.mol
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BAY-57-1293 Property

Boiling point:
639.4±65.0 °C(Predicted)
Density 
1.396±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
insoluble in H2O; insoluble in EtOH; ≥13.9 mg/mL in DMSO
form 
solid
pka
9.31±0.60(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22129
Product name
BAY 57-1293
Purity
≥98%
Packaging
5mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
22129
Product name
BAY 57-1293
Purity
≥98%
Packaging
50mg
Price
$160
Updated
2024/03/01
Cayman Chemical
Product number
22129
Product name
BAY 57-1293
Purity
≥98%
Packaging
1mg
Price
$25
Updated
2021/12/16
Cayman Chemical
Product number
22129
Product name
BAY 57-1293
Purity
≥98%
Packaging
10mg
Price
$56
Updated
2024/03/01
Cayman Chemical
Product number
22129
Product name
BAY 57-1293
Purity
≥98%
Packaging
25mg
Price
$112
Updated
2024/03/01
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BAY-57-1293 Chemical Properties,Usage,Production

Uses

BAY 57-1293 is a potent inhibitor of herpes simplex virus (HSV) that target the virus helicase primase complex.

Biological Activity

bay 57-1293 is a potent and safe inhibitor of hsv helicase-primase with ic50 value of 12nm [1].bay 57-1293 displays anti-herpes activity through inhibiting the helicase-primase and affecting the viral dna synthesis. in the in vitro viral replication assay, bay 57-1293 shows inhibition against hsv-1 f, hsv-2 g and acyclovir-resistant hsv-1 f mutant with ic50 value of 20nm. in the plaque reduction assay and the conventional cytopathogenicity assay, bay 57-1293 shows ic50 values of 0.01-0.02μm and 0.01-0.03μm, respectively. besides that, bay 57-1293 is active at an ic50 value of 10nm–30nm against all clinical isolates of hsv-1 and hsv-2. furthermore, bay 57-1293 is active in vivo. the oral administration of bay 57-1293 shows 10-fold more potent than valacyclovir in a murine model of disseminated herpes infection. in a rat lethal challenge model, bay 57-1293 exerts profound antiviral activity without toxic effects. [1, 2]

storage

Store at -20°C

References

[1] kleymann g, fischer r, betz u a k, et al. new helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease. nature medicine, 2002, 8(4): 392-398.
[2] betz u a k, fischer r, kleymann g, et al. potent in vivo antiviral activity of the herpes simplex virus primase-helicase inhibitor bay 57-1293. antimicrobial agents and chemotherapy, 2002, 46(6): 1766-1772.

BAY-57-1293 Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY-57-1293 Suppliers

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View Lastest Price from BAY-57-1293 manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
BAY-57-1293 348086-71-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-26
Career Henan Chemical Co
Product
BAY-57-1293 348086-71-5
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-07-09

348086-71-5, BAY-57-1293Related Search:


  • PRITELIVIR;AIC316
  • Benzeneacetamide, N-[5-(aminosulfonyl)-4-methyl-2-thiazolyl]-N-methyl-4-(2-pyridinyl)-
  • AIC316
  • N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide BAY57-1293 Pritelivir
  • 2-METHYL-2-PROPANYL [4-(CHLOROSULFONYL)PHENYL]CARBAMATE
  • BAY571293(Pritelivir)
  • BAY-57-1293
  • Pritelivir
  • N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide
  • Pritelivir,BAY-57-1293
  • BAY 57-1293 - Pritelivir | AIC 316
  • CS-857
  • PRITELIVIR; BAY-57-1293; AIC316
  • N-methyl-N-(4-methyl-5-sulfamoyl-1,3-thiazol-2-yl)-2-(4-pyridin-2-ylphenyl)acetamide
  • N-Methyl-N-(4-methyl-5-sulfamoylthiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide
  • N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-(4-pyridin-2-ylphenyl)acetamide
  • Pritelivir base
  • 348086-71-5
  • Inhibitors