GeMigliptin

Product Name: GeMigliptin
CAS No.: 911637-19-9
Chemical Name: GeMigliptin
Synonyms: LC15-0444;GeMigliptin;GeMigliptin WS;Gemigliptin - G10587;GeMigliptin Tartarate;Gemigliptin Hydrochloride;Product name:-Gemigliptintartarate;Inhibitor,DPP,Gemigliptin,Dipeptidyl Peptidase,inhibit;(S)-1-(2-Amino-4-(2,4-bis(trifluoromethyl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)-4-oxobutyl)-5,5-difluoropiperidin-2-one;1-[(2S)-2-amino-4-[2,4-bis(trifluoromethyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]-4-oxobutyl]-5,5-difluoropiperidin-2-one
CBNumber: CB82627898
Molecular Formula: C18H19F8N5O2
Formula Weight: 489.36
MOL File: 911637-19-9.mol

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GeMigliptin Property

Boiling point:: 539.1±50.0 °C(Predicted)
Density: 1.54±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:74.0(Max Conc. mg/mL);151.21(Max Conc. mM)
Ethanol:7.0(Max Conc. mg/mL);14.3(Max Conc. mM)
Water:12.0(Max Conc. mg/mL);24.52(Max Conc. mM)
form: Solid
pka: 7.33±0.10(Predicted)
color: White to orange

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: G337000
Product name: GemigliptinHydrochloride
Packaging: 25mg
Price: $13125
Updated: 2021/12/16

Matrix Scientific

Product number: 122479
Product name: Gemigliptin
Purity: 97.0%
Packaging: 1g
Price: $2655
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0013914
Product name: GEMIGLIPTIN
Purity: 95.00%
Packaging: 10MG
Price: $1582.35
Updated: 2021/12/16

ChemScene

Product number: CS-0003618
Product name: Gemigliptin
Packaging: 10mg
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-0003618
Product name: Gemigliptin
Packaging: 50mg
Price: $330
Updated: 2021/12/16

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GeMigliptin Chemical Properties,Usage,Production

Description

Gemigliptin is a prolyl-specific dipeptidyl aminopeptidase IV (DPP IV, DPP-4, CD26) inhibitor approved for the treatment of type 2 diabetes mellitus by the Korean Food and Drug Administration in 2012. Gemigliptin was discovered and developed by LG Life Sciences and is now the sixth DPP-4 inhibitor approved for the treatment of type 2 diabetes. At the time this review was prepared, there were no publications describing the discovery strategy and preclinical data that led to the advancement of gemigliptin to the clinic.

Uses

Gemigliptin Hydrochloride is used in biological studies as a novel dipeptidyl peptidase IV (DPP-IV) inhibitors and potential antidiabetic drug.

Definition

ChEBI: Gemigliptin is an organonitrogen compound and an organooxygen compound. It is functionally related to a beta-amino acid.

Synthesis

Commercial N-Boc-3-piperidone (71) was treated with LHMDS followed by ethyl trifluoroacetate to effect a Claisen condensation, producing diketone 72 in 81% yield. Cyclization of 72 with 2,2,2-trifluoroacetamide (73) gave bis-trifluoromethyl dihydropyridopyrimidine 74 in 23% yield. Removal of the Boc protecting group efficiently provided amine 75 in 96% yield.
1,4-Addition of ethyl bromodifluoroacetate (76) to ethyl acrylate (77) in the presence of copper powder and tetramethylethylenediamine (TMEDA) gave diester 78, which was selectively reduced with sodium borohydride (NaBH4) to give alcohol 79 in 90% overall yield for the two-step procedure. Alcohol 79 was then treated with perfluorobutanesulfonyl chloride and triethylamine to give activated alcohol 80 in 75% yield. Boc-L-aspartic acid 4-tert-butyl ester (81) was treated with ammonium bicarbonate and pyridine in the presence of di-tert-butyl dicarbonate to give formamide 82. Dehydration of 82 to give nitrile 83 was accomplished through reaction with cyanuric chloride in 95% overall yield for the two-step sequence. Hydrogenation of 83 in the presence of Pearlman?ˉs catalyst provided butyl amine 84. Alkylation of 84 with activated alcohol 80 in triethylamine followed by cyclization in acetic acid afforded difluoropyridone 85. Acidic hydrolysis of the ester proceeded with concomitant removal of the Boc protecting group, and was followed by reprotection of the amine with di-tert-butyl dicarbonate to give acid 86 in 84% overall yield for the three-step procedure in >97% ee. Coupling of 86 with fragment 75 in the presence of 1-hydroxybenzotriazole (HOBT) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) gave amide 87 in 51% yield. Removal of the Boc group with thionyl chloride in ethanol followed by neutralization with aqueous sodium hydroxide and salt formation with L-tartaric acid provided gemigliptin L-tartrate hydrate (X) in 97.5% yield.

GeMigliptin Preparation Products And Raw materials

Raw materials

Preparation Products

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GeMigliptin Suppliers

China 45 India 3 United Kingdom 1 United States 6 Global 55

Shanghai Hekang Biotechnology Co., Ltd.

Tel: 18939837085
Fax: 2880152141(QQ)
Email: youchemicals@gmail.com
Country: China
ProdList: 1830
Advantage: 55

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7887
Advantage: 56

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Chengdu DingDang Pharmaceutical Co., Ltd.

Tel: 028-86040038 13980902949;
Fax: 028-85149890
Email: market@dingdangchem.com
Country: China
ProdList: 1845
Advantage: 55

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
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Novachemistry

Tel: 44-20819178-90 02081917890
Fax: (0)2080432064
Email: info@novachemistry.com
Country: United Kingdom
ProdList: 4381
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911637-19-9, GeMigliptinRelated Search:

Trelagliptin

GeMigliptin

GeMigliptin Tartarate

Gemigliptin - G10587

(S)-1-(2-Amino-4-(2,4-bis(trifluoromethyl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)-4-oxobutyl)-5,5-difluoropiperidin-2-one

(S)-1-(2-amino-4-(2,4-bis(trifluoromethyl)-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl)-4-oxobutyl)-5,5-difluoropiperidin-2-one hydrochloride

GeMigliptin WS

LC15-0444

Gemigliptin Hydrochloride

Product name:-Gemigliptintartarate

2-Piperidinone, 1-[(2S)-2-amino-4-[5,8-dihydro-2,4-bis(trifluoromethyl)pyrido[3,4-d]pyrimidin-7(6H)-yl]-4-oxobutyl]-5,5-difluoro-

1-[(2S)-2-amino-4-[2,4-bis(trifluoromethyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]-4-oxobutyl]-5,5-difluoropiperidin-2-one

Inhibitor,DPP,Gemigliptin,Dipeptidyl Peptidase,inhibit

911637-19-9

C18H19F8N5O2