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GLI1-Mediated transcription inhibitor

Product Name
GLI1-Mediated transcription inhibitor
CAS No.
496794-70-8
Chemical Name
GLI1-Mediated transcription inhibitor
Synonyms
104683;HhAntag;GLI1-Mediated transcription inhibitor;HhAntag,Smoothened,Smo,Inhibitor,inhibit;N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3;N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide;N-[4-Chloro-3-[5-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide;BenzaMide, N-[4-chloro-3-[6-(diMethylaMino)-1H-benziMidazol-2-yl]phenyl]-3,5-diMethoxy-;N-(4-Chloro-3-(6-(dimethylamino)-1H-benzo[d]imidazol-2-yl)phenyl)-3,5-dimethoxybenzamide;N-(4-chloro-3-(5-(diMethylaMino)-1H-benzo[d]iMidazol-2-yl)phenyl)-3,5-diMethoxybenzaMide
CBNumber
CB82627904
Molecular Formula
C24H23ClN4O3
Formula Weight
450.92
MOL File
496794-70-8.mol
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GLI1-Mediated transcription inhibitor Property

Density 
1.337±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
insoluble in H2O; ≥13.3 mg/mL in DMSO; ≥52.3 mg/mL in EtOH with gentle warming
form 
solid
pka
10.34±0.10(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28296
Product name
HhAntag
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
28296
Product name
HhAntag
Packaging
25mg
Price
$456
Updated
2024/03/01
Cayman Chemical
Product number
28296
Product name
HhAntag
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
28296
Product name
HhAntag
Packaging
10mg
Price
$214
Updated
2024/03/01
ChemScene
Product number
CS-1233
Product name
HhAntag
Purity
98.70%
Packaging
5mg
Price
$295
Updated
2021/12/16
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GLI1-Mediated transcription inhibitor Chemical Properties,Usage,Production

Biological Activity

hhantag is a hedgehog signaling antagonist. ligand-dependent activation of the hedgehog (hh) signaling pathway has been associated with tumorigenesis in a number of human tissues.

in vitro

hhantag has been evaluated for its effect on hh pathway across a large panel of cancer cell lines. hhantag demonstrated to be around 10-times more potent than cyclopamine at inhibiting the activity of hh pathway. a range of cellular sensitivities to hhantag was observed with ic50 values for growth inhibition ranging from ~2 μm to >30 μm. in contrast to previous reports, no tissue specificity of in vitro sensitivity to hhantag was observed [1].

in vivo

oral administration of hhantag to mice with primary human xenografts resulted in significant growth delay in both pancreatic and colon adenocarcinoma models, with average tumour growth inhibitions of 29% and 48%, respectively. moreover, the hhantag doses required to inhibit the tumor growth were similar to the doses required to fully inhibit endogenous hh target genes in tumour stroma or in surrogate normal tissues, indicating that such growth inhibition was a specific consequence of hh inhibition [1].

IC 50

from ~2 μm to >30 μm

References

[1] yauch rl,gould se,scales sj,tang t,tian h,ahn cp,marshall d,fu l,januario t,kallop d,nannini-pepe m,kotkow k,marsters jc,rubin ll,de sauvage fj. a paracrine requirement for hedgehog signalling in cancer. nature.2008 sep 18;455(7211):406-10.

GLI1-Mediated transcription inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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GLI1-Mediated transcription inhibitor Suppliers

ChemShuttle, Inc.
Tel
0510-83588313-802 18800520310;
Email
sales@chemshuttle.com
Country
China
ProdList
3002
Advantage
62
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
17687
Advantage
55
Yancheng KangdiSen Pharmaceutical Co., Ltd.
Tel
13812573443
Fax
-
Email
tongbenwan22@163.com
Country
China
ProdList
1975
Advantage
55
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
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View Lastest Price from GLI1-Mediated transcription inhibitor manufacturers

Career Henan Chemical Co
Product
N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide 496794-70-8
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-01

496794-70-8, GLI1-Mediated transcription inhibitorRelated Search:


  • GLI1-Mediated transcription inhibitor
  • BenzaMide, N-[4-chloro-3-[6-(diMethylaMino)-1H-benziMidazol-2-yl]phenyl]-3,5-diMethoxy-
  • HhAntag
  • N-(4-chloro-3-(5-(diMethylaMino)-1H-benzo[d]iMidazol-2-yl)phenyl)-3,5-diMethoxybenzaMide
  • N-[4-Chloro-3-[5-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide
  • N-(4-Chloro-3-(6-(dimethylamino)-1H-benzo[d]imidazol-2-yl)phenyl)-3,5-dimethoxybenzamide
  • N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3
  • 104683
  • N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide
  • HhAntag,Smoothened,Smo,Inhibitor,inhibit
  • 496794-70-8