GLI1-Mediated transcription inhibitor
- Product Name
- GLI1-Mediated transcription inhibitor
- CAS No.
- 496794-70-8
- Chemical Name
- GLI1-Mediated transcription inhibitor
- Synonyms
- 104683;HhAntag;GLI1-Mediated transcription inhibitor;HhAntag,Smoothened,Smo,Inhibitor,inhibit;N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3;N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide;N-[4-Chloro-3-[5-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide;BenzaMide, N-[4-chloro-3-[6-(diMethylaMino)-1H-benziMidazol-2-yl]phenyl]-3,5-diMethoxy-;N-(4-Chloro-3-(6-(dimethylamino)-1H-benzo[d]imidazol-2-yl)phenyl)-3,5-dimethoxybenzamide;N-(4-chloro-3-(5-(diMethylaMino)-1H-benzo[d]iMidazol-2-yl)phenyl)-3,5-diMethoxybenzaMide
- CBNumber
- CB82627904
- Molecular Formula
- C24H23ClN4O3
- Formula Weight
- 450.92
- MOL File
- 496794-70-8.mol
GLI1-Mediated transcription inhibitor Property
- Density
- 1.337±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- insoluble in H2O; ≥13.3 mg/mL in DMSO; ≥52.3 mg/mL in EtOH with gentle warming
- form
- solid
- pka
- 10.34±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 28296
- Product name
- HhAntag
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 28296
- Product name
- HhAntag
- Packaging
- 25mg
- Price
- $456
- Updated
- 2024/03/01
- Product number
- 28296
- Product name
- HhAntag
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 28296
- Product name
- HhAntag
- Packaging
- 10mg
- Price
- $214
- Updated
- 2024/03/01
- Product number
- CS-1233
- Product name
- HhAntag
- Purity
- 98.70%
- Packaging
- 5mg
- Price
- $295
- Updated
- 2021/12/16
GLI1-Mediated transcription inhibitor Chemical Properties,Usage,Production
Biological Activity
hhantag is a hedgehog signaling antagonist. ligand-dependent activation of the hedgehog (hh) signaling pathway has been associated with tumorigenesis in a number of human tissues.
in vitro
hhantag has been evaluated for its effect on hh pathway across a large panel of cancer cell lines. hhantag demonstrated to be around 10-times more potent than cyclopamine at inhibiting the activity of hh pathway. a range of cellular sensitivities to hhantag was observed with ic50 values for growth inhibition ranging from ~2 μm to >30 μm. in contrast to previous reports, no tissue specificity of in vitro sensitivity to hhantag was observed [1].
in vivo
oral administration of hhantag to mice with primary human xenografts resulted in significant growth delay in both pancreatic and colon adenocarcinoma models, with average tumour growth inhibitions of 29% and 48%, respectively. moreover, the hhantag doses required to inhibit the tumor growth were similar to the doses required to fully inhibit endogenous hh target genes in tumour stroma or in surrogate normal tissues, indicating that such growth inhibition was a specific consequence of hh inhibition [1].
IC 50
from ~2 μm to >30 μm
References
[1] yauch rl,gould se,scales sj,tang t,tian h,ahn cp,marshall d,fu l,januario t,kallop d,nannini-pepe m,kotkow k,marsters jc,rubin ll,de sauvage fj. a paracrine requirement for hedgehog signalling in cancer. nature.2008 sep 18;455(7211):406-10.
GLI1-Mediated transcription inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from GLI1-Mediated transcription inhibitor manufacturers
- Product
- N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide 496794-70-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-01-01