GLI1-Mediated transcription inhibitor

Product Name: GLI1-Mediated transcription inhibitor
CAS No.: 496794-70-8
Chemical Name: GLI1-Mediated transcription inhibitor
Synonyms: 104683;HhAntag;GLI1-Mediated transcription inhibitor;HhAntag,Smoothened,Smo,Inhibitor,inhibit;N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3;N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide;N-[4-Chloro-3-[5-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide;BenzaMide, N-[4-chloro-3-[6-(diMethylaMino)-1H-benziMidazol-2-yl]phenyl]-3,5-diMethoxy-;N-(4-Chloro-3-(6-(dimethylamino)-1H-benzo[d]imidazol-2-yl)phenyl)-3,5-dimethoxybenzamide;N-(4-chloro-3-(5-(diMethylaMino)-1H-benzo[d]iMidazol-2-yl)phenyl)-3,5-diMethoxybenzaMide
CBNumber: CB82627904
Molecular Formula: C24H23ClN4O3
Formula Weight: 450.92
MOL File: 496794-70-8.mol

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GLI1-Mediated transcription inhibitor Property

Density: 1.337±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: insoluble in H2O; ≥13.3 mg/mL in DMSO; ≥52.3 mg/mL in EtOH with gentle warming
form: solid
pka: 10.34±0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28296
Product name: HhAntag
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 28296
Product name: HhAntag
Packaging: 25mg
Price: $456
Updated: 2024/03/01

Cayman Chemical

Product number: 28296
Product name: HhAntag
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 28296
Product name: HhAntag
Packaging: 10mg
Price: $214
Updated: 2024/03/01

ChemScene

Product number: CS-1233
Product name: HhAntag
Purity: 98.70%
Packaging: 5mg
Price: $295
Updated: 2021/12/16

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GLI1-Mediated transcription inhibitor Chemical Properties,Usage,Production

Biological Activity

hhantag is a hedgehog signaling antagonist. ligand-dependent activation of the hedgehog (hh) signaling pathway has been associated with tumorigenesis in a number of human tissues.

in vitro

hhantag has been evaluated for its effect on hh pathway across a large panel of cancer cell lines. hhantag demonstrated to be around 10-times more potent than cyclopamine at inhibiting the activity of hh pathway. a range of cellular sensitivities to hhantag was observed with ic50 values for growth inhibition ranging from ~2 μm to >30 μm. in contrast to previous reports, no tissue specificity of in vitro sensitivity to hhantag was observed [1].

in vivo

oral administration of hhantag to mice with primary human xenografts resulted in significant growth delay in both pancreatic and colon adenocarcinoma models, with average tumour growth inhibitions of 29% and 48%, respectively. moreover, the hhantag doses required to inhibit the tumor growth were similar to the doses required to fully inhibit endogenous hh target genes in tumour stroma or in surrogate normal tissues, indicating that such growth inhibition was a specific consequence of hh inhibition [1].

IC 50

from ~2 μm to >30 μm

References

[1] yauch rl,gould se,scales sj,tang t,tian h,ahn cp,marshall d,fu l,januario t,kallop d,nannini-pepe m,kotkow k,marsters jc,rubin ll,de sauvage fj. a paracrine requirement for hedgehog signalling in cancer. nature.2008 sep 18;455(7211):406-10.

GLI1-Mediated transcription inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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GLI1-Mediated transcription inhibitor Suppliers

China 45 United States 11 Global 56

MedChemexpress LLC

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Musechem

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TargetMol Chemicals Inc.

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Aladdin Scientific

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Creative Enzymes

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Matrix Scientific

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View Lastest Price from GLI1-Mediated transcription inhibitor manufacturers

Career Henan Chemical Co

Product: N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide 496794-70-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

496794-70-8, GLI1-Mediated transcription inhibitorRelated Search:

N-(4-chloro-3-(5-(dimethylamino)-1H-benzo[d]imidazol-2-yl)phenyl)-3,5-dimethoxybenzamide hydrochloride

GLI1-Mediated transcription inhibitor

BenzaMide, N-[4-chloro-3-[6-(diMethylaMino)-1H-benziMidazol-2-yl]phenyl]-3,5-diMethoxy-

HhAntag

N-(4-chloro-3-(5-(diMethylaMino)-1H-benzo[d]iMidazol-2-yl)phenyl)-3,5-diMethoxybenzaMide

N-[4-Chloro-3-[5-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide

N-(4-Chloro-3-(6-(dimethylamino)-1H-benzo[d]imidazol-2-yl)phenyl)-3,5-dimethoxybenzamide

N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3

104683

N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide

HhAntag,Smoothened,Smo,Inhibitor,inhibit

496794-70-8