LOR 253

Product Name: LOR 253
CAS No.: 916151-99-0
Chemical Name: LOR 253
Synonyms: LT-253;LOR 253;APTO-253;LOR-253; LT-253;APTO-253 (LOR-253);LOR 253; LOR253; LT-253;APTO-253, 10 mM in DMSO;2-(5-Fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline;1H-Imidazo[4,5-f][1,10]phenanthroline, 2-(5-fluoro-2-methyl-1H-indol-3-yl)-;LT 253,LT253,Myc,c-Myc,inhibit,APTO 253,LOR 253,APTO253,KLF,Apoptosis,Inhibitor,Krüppel-like factor,APTO-253,LOR253
CBNumber: CB82628042
Molecular Formula: C22H14FN5
Formula Weight: 367.38
MOL File: 916151-99-0.mol

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LOR 253 Property

Boiling point:: 718.8±70.0 °C(Predicted)
Density: 1.481±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 2 mg/ml; DMSO: 2 mg/ml; Ethanol: insol; PBS (pH 7.2): insol
form: A solid
pka: 7.75±0.50(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: BA166663
Product name: APTO 253
Packaging: 10mg
Price: $135
Updated: 2021/12/16

ChemScene

Product number: CS-5226
Product name: APTO-253
Purity: 98.15%
Packaging: 10mg
Price: $144
Updated: 2021/12/16

AK Scientific

Product number: 1798CT
Product name: 2-(5-Fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline
Packaging: 10mg
Price: $232
Updated: 2021/12/16

ChemScene

Product number: CS-5226
Product name: APTO-253
Purity: 98.15%
Packaging: 50mg
Price: $456
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BA166663
Product name: APTO 253
Packaging: 50mg
Price: $472.5
Updated: 2021/12/16

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LOR 253 Chemical Properties,Usage,Production

Uses

APTO-253 (LOR-253) is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates anticancer activity through induction of the Krüppel-like factor 4 (KLF4) tumor suppressor[1][2]. APTO-253 has antiarthritic activity[3].

in vivo

APTO-253 (LOR-253; 15 mg/kg; IV; twice per day for 2 consecutive days per week for 14 days) has antiarthritic activity in a CIA model^[3].

Animal Model:	DBA/1J male mice (6 weeks) with collagen induced arthritis (CIA)^[3]
Dosage:	15 mg/kg
Administration:	IV; twice per day for 2 consecutive days per week for 14 days
Result:	Demonstrated significant preventive and therapeutic activity on arthritis formation.

References

[1] Local A, et al. APTO-253 Stabilizes G-quadruplex DNA, Inhibits MYC Expression, and Induces DNA Damage in Acute Myeloid Leukemia Cells. Mol Cancer Ther. 2018 Jun;17(6):1177-1186. DOI:10.1158/1535-7163.MCT-17-1209
[2] Hongying Zhang, et al. Inhibition of c-Myc By Apto-253 As an Innovative Therapeutic Approach to Induce Cell Cycle Arrest and Apoptosis in Acute Myeloid Leukemia. Blood 2016 128:1716.
[3] Haruka Tsuchiya, et al. Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritis. Ann Rheum Dis. 2020 Nov2;annrheumdis-2020-218189. DOI:10.1136/annrheumdis-2020-218189

LOR 253 Preparation Products And Raw materials

Raw materials

Preparation Products

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LOR 253 Suppliers

China 58 United Kingdom 1 United States 7 Global 66

NCE Biomedical Co.,Ltd.

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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
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AdooQ BioScience, LLC

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Email: info@adooq.com
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Shanghai Lollane Biological Technology Co.,Ltd.

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Fax: +86-21-52996696
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SPIRO PHARMA

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Guangzhou QiYun Biotechnology Co., Ltd.

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Shanghai YuanYe Biotechnology Co., Ltd.

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Amadis Chemical Company Limited

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MQ (shanghai) Pharmaceuticals Co., Ltd.

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Musechem

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Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
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916151-99-0, LOR 253Related Search:

LOR 253

APTO-253

LOR 253; LOR253; LT-253

LOR-253; LT-253

LT-253

1H-Imidazo[4,5-f][1,10]phenanthroline, 2-(5-fluoro-2-methyl-1H-indol-3-yl)-

APTO-253 (LOR-253)

LT 253,LT253,Myc,c-Myc,inhibit,APTO 253,LOR 253,APTO253,KLF,Apoptosis,Inhibitor,Krüppel-like factor,APTO-253,LOR253

2-(5-Fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline

APTO-253, 10 mM in DMSO

916151-99-0

C22H14FN5