MibaMpator

Product Name: MibaMpator
CAS No.: 375345-95-2
Chemical Name: MibaMpator
Synonyms: CS-1234;LY 451395;MibaMpator;Mibampator?(LY451395);MIBAMPATOR;LY 451395;LY-451395;(R)-N-(2-(4'-(2-(Methylsulfonamido)ethyl)-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide;(R)-N-(2-(4'-(2-(Methylsulfonamido)ethyl)-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide;2-Propanesulfonamide, N-[(2R)-2-[4'-[2-[(methylsulfonyl)amino]ethyl][1,1'-biphenyl]-4-yl]propyl]-;[(2R)-2-[4-[4-[2-[(Methylsulfonyl)amino]ethyl]phenyl]phenyl]propyl][(1-methylethyl)sulfonyl]amine
CBNumber: CB82628062
Molecular Formula: C21H30N2O4S2
Formula Weight: 438.6
MOL File: 375345-95-2.mol

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MibaMpator Property

Boiling point:: 609.4±65.0 °C(Predicted)
Density: 1.205±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 11.05±0.40(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-3166
Product name: Mibampator
Purity: 99.89%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ApexBio Technology

Product number: B4658
Product name: LY451395
Packaging: 5mg
Price: $551
Updated: 2021/12/16

ChemScene

Product number: CS-3166
Product name: Mibampator
Purity: 99.89%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611794
Product name: LY451395
Packaging: 10mg
Price: $615.4
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0013996
Product name: LY-451395
Purity: 95.00%
Packaging: 5MG
Price: $660
Updated: 2021/12/16

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MibaMpator Chemical Properties,Usage,Production

Biological Activity

ly451395 (mibampator) is a powerful, highly selective and biarylsulfonamide potentiator of ampa receptors [1].ly451395 (mibampator) has been found to be a potent, selective and centrally active positive allosteric modulators of ampa receptor-mediated neurotransmission, which enhances ion channel flux in the presence of agonist by inhibiting desensitization and deactivation of the receptors. in addition, ly451395 has been revealed to enhance synaptic transmission. besides, ly451395 has been reported to attenuate the response to acute ethanol administration in the rat in vivo [1]. moreover, the in vivo metabolisms of ly451395 in mouse, rat, dog and human have produced several phase 1 oxidative metabolites [2].

References

[1] jones n1, messenger mj, o'neill mj, oldershaw a, gilmour g, simmons rm, iyengar s, libri v, tricklebank m, williams sc. ampa receptor potentiation can prevent ethanol-induced intoxication. neuropsychopharmacology. 2008 jun;33(7):1713-23. epub 2007 sep 12.
[2] zmijewski m1, gillespie ta, jackson da, schmidt df, yi p, kulanthaivel p. application of biocatalysis to drug metabolism: preparation of mammalian metabolites of a biaryl-bis-sulfonamide ampa (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor potentiator using actinoplanes missouriensis. drug metab dispos. 2006 jun;34(6):925-31. epub 2006 feb 28.

MibaMpator Preparation Products And Raw materials

Raw materials

Preparation Products

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MibaMpator Suppliers

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375345-95-2, MibaMpatorRelated Search:

MIBAMPATOR;LY 451395;LY-451395

CS-1234

MibaMpator

[(2R)-2-[4-[4-[2-[(Methylsulfonyl)amino]ethyl]phenyl]phenyl]propyl][(1-methylethyl)sulfonyl]amine

LY 451395

2-Propanesulfonamide, N-[(2R)-2-[4'-[2-[(methylsulfonyl)amino]ethyl][1,1'-biphenyl]-4-yl]propyl]-

Mibampator?(LY451395)

(R)-N-(2-(4'-(2-(Methylsulfonamido)ethyl)-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide

375345-95-2