PSI 7851

Product Name: PSI 7851
CAS No.: 1064684-44-1
Chemical Name: PSI 7851
Synonyms: GS9851;GS 9851;CS-1996;GS-9851;PSI 7851;PSI-7977, SOFOSBUVIR;5'-O-(isopropyl-L-alanate,phenyl-phosphoramidyl)-2'-deoxy-2'-fluoro-2'-C-methyl-uridine;N-[(2'R)-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester;L-Alanine, N-[(2'R)-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-, 1-methylethyl ester;(2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate (Sofosbuvir Impurity）
CBNumber: CB82628299
Molecular Formula: C22H29FN3O9P
Formula Weight: 529.45
MOL File: 1064684-44-1.mol

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PSI 7851 Property

Density: 1.41±0.1 g/cm3(Predicted)
pka: 9.39±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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PSI 7851 Chemical Properties,Usage,Production

Uses

GS-9851 (PSI-7851) is an HCV nonstructural protein 5B (NS5B) inhibitor with potential activity for the treatment of HCV infection. GS-9851 showed good tolerability in patients with initial HCV genotype 1 infection. GS-9851 is rapidly cleared from the body with a half-life of approximately 1 hour. The maximum concentration of GS-9851 and the increase in the area under the compound concentration-time curve were not dose-proportional, especially at the highest dose[1].

References

[1] Pharmacokinetics, pharmacodynamics, and tolerability of GS-9851, a nucleotide analog polymerase inhibitor, following multiple ascending doses in patients with chronic hepatitis C infection
[2] Discovery of a β-D-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus J. Med. Chem., Article ASAP DOI: 10.1021/jm100863x Publication Date (Web): September 16, 2010

PSI 7851 Preparation Products And Raw materials

Raw materials

Preparation Products

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PSI 7851 Suppliers

China 14 United States 3 Global 17

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

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View Lastest Price from PSI 7851 manufacturers

Career Henan Chemical Co

Product: PSI 7851 1064684-44-1
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-08-06

1064684-44-1, PSI 7851Related Search:

(S)-methyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate D-Alanine, N-[[P(R),2'R]-2'-deoxy-2'-fluoro-2'-Methyl-P-phenyl-5'-uridylyl]-, 1-Methylethyl ester Sofosbuvir impurity M (R)-isopropyl 2-(((R)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate

PSI 7851

N-[(2'R)-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester

PSI-7977, SOFOSBUVIR

CS-1996

L-Alanine, N-[(2'R)-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-, 1-methylethyl ester

GS 9851

GS9851

GS-9851

5'-O-(isopropyl-L-alanate,phenyl-phosphoramidyl)-2'-deoxy-2'-fluoro-2'-C-methyl-uridine

(2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate (Sofosbuvir Impurity）

1064684-44-1