Pyrintegrin

Product Name: Pyrintegrin
CAS No.: 1228445-38-2
Chemical Name: Pyrintegrin
Synonyms: Pyrintegrin;N-(Cyclopropylmethyl)-4-[[4-(3,4-dihydro-6-hydroxy-1(2H)-quinolinyl)-2-pyrimidinyl]amino]benzenesulfonamide;N-(Cyclopropylmethyl)-4-{[4-(6-hydroxy-3,4-dihydro-1(2H)-quinolinyl)-2-pyrimidinyl]amino}benzenesulfonamide;Benzenesulfonamide, N-(cyclopropylmethyl)-4-[[4-(3,4-dihydro-6-hydroxy-1(2H)-quinolinyl)-2-pyrimidinyl]amino]-;nephropathy,C/EBPα,embryonic,stem,inhibit,β1-integrin,PPARγ,Integrin,Pyrintegrin,Adipogenic,cells,Inhibitor,podocyte-protective,ECM,proteinuria
CBNumber: CB82628330
Molecular Formula: C23H25N5O3S
Formula Weight: 451.54
MOL File: 1228445-38-2.mol

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Pyrintegrin Property

Boiling point:: 729.3±70.0 °C(Predicted)
Density: 1.401±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤1mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide
form: crystalline solid
pka: 9.75±0.20(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16179
Product name: Pyrintegrin
Purity: ≥95%
Packaging: 1mg
Price: $84
Updated: 2024/03/01

Cayman Chemical

Product number: 16179
Product name: Pyrintegrin
Purity: ≥95%
Packaging: 5mg
Price: $225
Updated: 2024/03/01

Cayman Chemical

Product number: 16179
Product name: Pyrintegrin
Purity: ≥95%
Packaging: 10mg
Price: $328
Updated: 2024/03/01

Tocris

Product number: 4978
Product name: Pyrintegrin
Purity: ≥98%(HPLC)
Packaging: 10
Price: $360
Updated: 2021/12/16

Usbiological

Product number: P9523
Product name: Pyrintegrin
Packaging: 1mg
Price: $350
Updated: 2021/12/16

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Pyrintegrin Chemical Properties,Usage,Production

Uses

Pyrintegrin enhances the survival of Human embryonic stem cells (hESC).

Biological Activity

pyrintegrin, a 2,4-disubstituted pyrimidine, is a novel small-molecule inhibitor of bmp signaling which previously found to promote human embryonic stem cells survival [1].bone morphogenetic proteins (bmps) are members of the tgf-β superfamily of secreted signaling molecules with important roles in many biological contexts. bmps could bind to specificserine/threonine kinase receptors and transduce the signal to the nucleus through smad proteins [2].

in vitro

pyrintegrin induced differentiation of hadscs into adipogenic‐like cells in vitro. pyrintegrin drug treatment can accelerate adipocyte differentiation and augment lipid accumulation, adiponectin and fatty acid secretion in adipogenic medium differentiated human adipose derived stem cells [1]. pyrimidine (2 μm) enhanced the survival of hesc more than 30-fold after trypsin-mediated dissociation. pyrimidine increased integrin-dependent attachment of hesc to extracellular matrices without significantly impacting cell proliferation. pyrintegrin increased the binding of the activated β1 integrin-specific antibody huts-21 and enhanced the phosphorylation of multiple growth factor receptors and their downstream kinases, pi3k and mapk [3].

in vivo

pyrintegrin promoted proliferation and differentiation of adipose precursor cells depending on their microenvironment. pyrintegrin increased the number of preadipocytes and the rate of adipocyte differentiation, resulting in enhanced de novo adipogenesis [1].

storage

Store at +4°C

References

[1] shah b s. pyrintegrin induced adipogenesis: biology[d]. columbia university, 2012.
[2] von bubnoff a, cho k w y. intracellular bmp signaling regulation in vertebrates: pathway or network[j]. developmental biology, 2001, 239(1): 1-14.
[3] xu y, zhu x, hahm h s, et al. revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules[j]. proceedings of the national academy of sciences, 2010, 107(18): 8129-8134.

Pyrintegrin Preparation Products And Raw materials

Raw materials

Preparation Products

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Pyrintegrin Suppliers

China 54 India 1 United Kingdom 1 United States 6 Global 62

Shanghai Changyan Chem & Tech Co., Ltd.

Tel: 021-20242659 18930833303
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Shanghai Chaolan Chemical Technology Center

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Country: China
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
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InvivoChem

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Shanghai Dongyang Biotechnology Co., Ltd.

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DC Chemicals

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Absin Bioscience Inc.

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Energy Chemical

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1228445-38-2, PyrintegrinRelated Search:

Pyrintegrin

N-(Cyclopropylmethyl)-4-{[4-(6-hydroxy-3,4-dihydro-1(2H)-quinolinyl)-2-pyrimidinyl]amino}benzenesulfonamide

N-(Cyclopropylmethyl)-4-[[4-(3,4-dihydro-6-hydroxy-1(2H)-quinolinyl)-2-pyrimidinyl]amino]benzenesulfonamide

Benzenesulfonamide, N-(cyclopropylmethyl)-4-[[4-(3,4-dihydro-6-hydroxy-1(2H)-quinolinyl)-2-pyrimidinyl]amino]-

nephropathy,C/EBPα,embryonic,stem,inhibit,β1-integrin,PPARγ,Integrin,Pyrintegrin,Adipogenic,cells,Inhibitor,podocyte-protective,ECM,proteinuria

1228445-38-2