ChemicalBook > CAS DataBase List > (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one

(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one

Product Name
(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one
CAS No.
39777-61-2
Chemical Name
(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one
Synonyms
RPN77612;TFEB activator 1;Curcumin analog C1;Curcumin analog compound C1;TFEB activator 1, 10 mM in DMSO;Curcumin analog C1(TFEB activator 1 );(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1;1,5-Bis-(2-methoxy-phenyl)-penta-1,4-dien-3-one;(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one;(1E,4E)-1,5-Bis(2-methoxyphenyl)-1,4-pentadien-3-one
CBNumber
CB82631480
Molecular Formula
C19H18O3
Formula Weight
294.34
MOL File
39777-61-2.mol
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(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one Property

Melting point:
120-122 °C(Solv: ethanol (64-17-5); water (7732-18-5))
Boiling point:
467.2±40.0 °C(Predicted)
Density 
1.128±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 125 mg/mL (424.68 mM)
form 
A solid
color 
Light yellow to yellow
InChI
InChI=1S/C19H18O3/c1-21-18-9-5-3-7-15(18)11-13-17(20)14-12-16-8-4-6-10-19(16)22-2/h3-14H,1-2H3/b13-11+,14-12+
InChIKey
RCZMPCUUTSDNAJ-PHEQNACWSA-N
SMILES
C(/C1=CC=CC=C1OC)=C\C(=O)/C=C/C1=CC=CC=C1OC
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
C3883
Product name
Curcumin Analog C1
Packaging
25MG
Price
$127
Updated
2025/07/31
AK Scientific
Product number
X5503
Product name
(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one
Packaging
50mg
Price
$196
Updated
2021/12/16
CSNpharm
Product number
CSN25353
Product name
TFEBactivator1
Packaging
100mg
Price
$300
Updated
2021/12/16
Ambeed
Product number
A370554
Product name
(1E,4E)-1,5-Bis(2-methoxyphenyl)penta-1,4-dien-3-one
Purity
95%
Packaging
250mg
Price
$346
Updated
2021/12/16
DC Chemicals
Product number
013005
Product name
CurcuminanalogC1(TFEBactivator1)
Packaging
002
Price
$800
Updated
2021/12/16
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(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one Chemical Properties,Usage,Production

Uses

TFEB activator 1 is an orally effective, mTOR-independent activator of TFEB. TFEB activator 1 significantly promotes the nuclear translocation of Flag-TFEB with an EC50 of 2167 nM. TFEB activator 1 enhances autophagy without inhibiting the mTOR pathway and has the potential for neurodegenerative diseases treatment[1].

in vivo

The medium lethal dose (LD50) value of TFEB activator 1 (Compound C1) is 175 mg/kg in the acute toxicity assay (single-dose i.v. tail vein injection; in rats) [1].
? Short-term oral administration of TFEB activator 1 (low dosage 10 mg/kg and high dosage 25 mg/kg; for 24 h) dose-dependently increases the expression of LC3B-II and TFEB in the liver, frontal cortex and striatum of the brain[1].
? Chronic administration of TFEB activator 1 (10 mg/kg per day; orally administered by gavage) activates TFEB and enhances autophagy in rat brains[1].

Animal Model:Adult male Sprague-Dawley (SD) rats weighing 350 to 400 g[1]
Dosage:10 mg/kg and 25 mg/kg
Administration:Short-term oral administration; for 24 hours
Result:Activated TFEB and enhanced autophagy and lysosome biogenesis in rat brain.
Animal Model:Adult male Sprague-Dawley (SD) rats weighing 350 to 400 g[1]
Dosage:10 mg/kg
Administration:Chronic oral administration; daily; for 21 days
Result:Activated TFEB and enhanced autophagy in rat brains.

References

[1] Song JX, et al. A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. Autophagy. 2016 Aug 2;12(8):1372-89. DOI:10.1080/15548627.2016.1179404

(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one Preparation Products And Raw materials

Raw materials

Preparation Products

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(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one Suppliers

Canada 1 China 62 The Netherlands 1 United States 7 Global 71
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The Netherlands
ProdList
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