Benzaldehyde, 3-broMo-5-fluoro-2-hydroxy-
- Product Name
- Benzaldehyde, 3-broMo-5-fluoro-2-hydroxy-
- CAS No.
- 178546-34-4
- Chemical Name
- Benzaldehyde, 3-broMo-5-fluoro-2-hydroxy-
- Synonyms
- 3-bromo-5-fluoro-2-hydoxybenzaldehyde;Benzaldehyde, 3-broMo-5-fluoro-2-hydroxy-;Benzaldehyde, 3-broMo-5-fluoro-2-hydroxy- ISO 9001：2015 REACH
- CBNumber
- CB82639527
- Molecular Formula
- C7H4BrFO2
- Formula Weight
- 219.01
- MOL File
- 178546-34-4.mol
Benzaldehyde, 3-broMo-5-fluoro-2-hydroxy- Property
- Boiling point:
- 223.3±35.0 °C(Predicted)
- Density
- 1.826±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 6.66±0.23(Predicted)
- Appearance
- Light yellow to brown Solid
Safety
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B678563
- Product name
- 3-Bromo-5-fluoro-2-hydroxybenzaldehyde
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB143559
- Product name
- 3-Bromo-5-fluoro-2-hydroxybenzaldehyde
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- PC2607
- Product name
- 3-Bromo-5-fluoro-2-hydroxybenzaldehyde
- Packaging
- 1g
- Price
- $114
- Updated
- 2021/12/16
- Product number
- 2615-B-14
- Product name
- 3-Bromo-5-fluoro-2-hydroxybenzaldehyde
- Packaging
- 1g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- PC2607
- Product name
- 3-Bromo-5-fluoro-2-hydroxybenzaldehyde
- Packaging
- 250mg
- Price
- $38
- Updated
- 2021/12/16
Benzaldehyde, 3-broMo-5-fluoro-2-hydroxy- Chemical Properties,Usage,Production
Synthesis
50-00-0
496-69-5
178546-34-4
The general procedure for the synthesis of 3-bromo-5-fluoro-2-hydroxybenzaldehyde from formaldehyde and 2-bromo-4-fluorophenol was as follows: to a reaction vial containing MgCl2 (powder, 325 mesh, 5.0 g, 52 mmol, 2 eq.) was added paraformaldehyde (3.0 g, 79 mmol, 3 eq.) and triethylamine (Et3N, 7.0 mL, 52 mmol, 2 eq.) in a THF (60 mL) solution. Subsequently, 2-bromo-4-fluorophenol (5.0 g, 26 mmol, 1 eq.) was added and heated in a microwave reactor at 160 °C for 15 min. The progress of the reaction was monitored by TLC (unfolding agent ratio 3:2 hexane:DCM) to confirm complete consumption of the feedstock. Upon completion of the reaction, THF was removed by evaporation, and the reaction mixture was dissolved in ethyl acetate (EtOAc), washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to afford the crude product 3-bromo-5-fluoro-2-hydroxybenzaldehyde (5.2 g) in 93% yield, which was ready for use in the subsequent steps without further purification.
References
[1] Patent: US2008/114167, 2008, A1. Location in patent: Page/Page column 184
Benzaldehyde, 3-broMo-5-fluoro-2-hydroxy- Preparation Products And Raw materials
Raw materials
Preparation Products
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