ChemicalBook > CAS DataBase List > 1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea

1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea

Product Name: 1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea
CAS No.: 1155877-97-6
Chemical Name: 1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea
Synonyms: D159687;D-159687 - Bio-X ?;D159687, 10 mM in DMSO;D159687; D-159687; D 159687;1-(4-((3'-chloro-6-methoxybiphenyl-3-yl)methyl)phenyl)urea;Inhibitor,inhibit,D159687,D-159687,Phosphodiesterase (PDE);[4-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]phenyl]urea;4-({3'-chloro-6-methoxy-[1,1'-biphenyl]-3-yl}methyl)phenyl]urea;1-(4-((3'-Chloro-6-methoxy-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea;Urea, N-[4-[(3'-chloro-6-methoxy[1,1'-biphenyl]-3-yl)methyl]phenyl]-
CBNumber: CB82642455
Molecular Formula: C21H19ClN2O2
Formula Weight: 366.84
MOL File: 1155877-97-6.mol

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1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea Property

Boiling point:: 502.0±50.0 °C(Predicted)
Density: 1.263±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO : 150 mg/mL (408.90 mM)
pka: 14.48±0.50(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3379
Product name: D159687
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $71.34
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3379
Product name: D159687
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $302
Updated: 2025/07/31

TRC

Product number: D100015
Product name: D-159687
Packaging: 2.5mg
Price: $615
Updated: 2021/12/16

ChemScene

Product number: CS-0006508
Product name: D159687
Purity: 98.00%
Packaging: 10mg
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-0006508
Product name: D159687
Purity: 98.00%
Packaging: 5mg
Price: $450
Updated: 2021/12/16

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1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea Chemical Properties,Usage,Production

Uses

D-159687 is a selective inhibitor of cyclic AMP phosphodiesterase 4D (PDE4D).

Biological Activity

D159687 is a brain-penetrant, orally available, highly potent and selective negative allosteric modulator (NAM) against phosphodiesterase 4 (PDE4) subtype PDE4D (hPDE4D7 IC50 = 27 nM; PDE4A1/B1/C1 IC50 = 2.50/1.47/6.80 μM; IC50 ≥29 μM against PDE1/2/3/5/7/8/9/10/11 subtypes). Comparing to Rolipram, D159678 offers similar in vivo efficacy on long-term memory formation by novel object recognition test (MED = 3 μg/kg mouse iv., 1 μg/kg r at p.o.), while being more effective in the scopolamine-impaired Y-maze tests (D159678/Rolipram MED = 0.1/1 μg/kg mouse iv. or 30/100 μg/kg mouse p.o.) and much less emetic in shrews/dog/monkeys (by 100-/3000-/500-fold).

in vivo

D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques^[2].

Animal Model:	Female Cynomolgus macaques (4–6 year old) ^[2]
Dosage:	0.05, 0.5, 5 mg/kg
Administration:	Oral daily for a week
Result:	A potential recruitment or enhancement of synaptic function with increased task difficulty.

IC 50

PDE4

1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea Preparation Products And Raw materials

Raw materials

Preparation Products

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1155877-97-6, 1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)ureaRelated Search:

D159687

1-(4-((3'-chloro-6-methoxybiphenyl-3-yl)methyl)phenyl)urea

D159687; D-159687; D 159687

Urea, N-[4-[(3'-chloro-6-methoxy[1,1'-biphenyl]-3-yl)methyl]phenyl]-

[4-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]phenyl]urea

Inhibitor,inhibit,D159687,D-159687,Phosphodiesterase (PDE)

1-(4-((3'-Chloro-6-methoxy-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea

4-({3'-chloro-6-methoxy-[1,1'-biphenyl]-3-yl}methyl)phenyl]urea

D159687, 10 mM in DMSO

D-159687 - Bio-X ?

1155877-97-6