2'-hydroxy-5'-(trifluoroMethyl)acetophenone
- Product Name
- 2'-hydroxy-5'-(trifluoroMethyl)acetophenone
- CAS No.
- 67589-15-5
- Chemical Name
- 2'-hydroxy-5'-(trifluoroMethyl)acetophenone
- Synonyms
- 1-(2-HYDROXY-5-(TRIFLUOROMETHY;2-Acetyl-4-(trifluoromethyl)phenol;2'-hydroxy-5'-(trifluoroMethyl)acetophenone;1-(2-Hydroxy-5-(trifluoromethyl)phenyl)ethano...;Ethanone, 1-[2-hydroxy-5-(trifluoromethyl)phenyl]-
- CBNumber
- CB82645355
- Molecular Formula
- C9H7F3O2
- Formula Weight
- 204.15
- MOL File
- 67589-15-5.mol
2'-hydroxy-5'-(trifluoroMethyl)acetophenone Property
- Boiling point:
- 219.7±35.0 °C(Predicted)
- Density
- 1.335±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 8.76±0.18(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A189638
- Product name
- 2-Acetyl-4-(trifluoromethyl)phenol
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- A189638
- Product name
- 2-Acetyl-4-(trifluoromethyl)phenol
- Packaging
- 250mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- HCH0361814
- Product name
- 1-(2-HYDROXY-5-(TRIFLUOROMETHYL)PHENYL)ETHANONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.59
- Updated
- 2021/12/16
- Product number
- 0406AC
- Product name
- 2'-Hydroxy-5'-(trifluoromethyl)acetophenone
- Packaging
- 1g
- Price
- $221
- Updated
- 2021/12/16
- Product number
- 120052
- Product name
- 1-(2-Hydroxy-5-(trifluoromethyl)phenyl)ethanone
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $252
- Updated
- 2021/12/16
2'-hydroxy-5'-(trifluoroMethyl)acetophenone Chemical Properties,Usage,Production
Uses
2-Acetyl-4-(trifluoromethyl)phenol was used to study benzoxazepine-based Orexin-2 receptor antagonists.
Preparation
Preparation by reaction of acetyl chloride with p-(trifluoromethyl)phenol in hydrofluoric acid for 6 h to 100° under 3 atm (88%).
Synthesis
503464-99-1
67589-15-5
The general procedure for the synthesis of 1-(2-hydroxy-5-(trifluoromethyl)phenyl)ethanone from 1-(2-methoxy-5-(trifluoromethyl)phenyl)ethanone was as follows: ethanethiol (EtSH, 8.59 mL, 116 mmol) was slowly added to sodium hydride (NaH, 60% dispersed in mineral oil, 4.64 g, 116 mmol) at 0 °C in N,N- dimethylformamide (DMF, 300 mL) in suspension. After stirring the reaction mixture for 15 min, 1-(2-methoxy-5-trifluoromethylphenyl)ethanone (24.0 g, 110 mmol) was added and the mixture was subsequently heated to 100 °C and stirred continuously for 30 min. After completion of the reaction, it was cooled to room temperature and the reaction mixture was slowly poured into water, acidified with 1 M hydrochloric acid (HCl) to pH acidic and subsequently extracted with ethyl acetate (AcOEt). The organic phases were combined, washed sequentially with water and saturated brine, dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography using hexane/ethyl acetate (10:1, v/v) as eluent to afford the target product 1-(2-hydroxy-5-(trifluoromethyl)phenyl)ethanone (5k, 17.7 g, 79% yield) as a light yellow oil.
References
[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 16, p. 7029 - 7042
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 21, p. 6414 - 6416
[3] Patent: WO2011/51478, 2011, A1. Location in patent: Page/Page column 55-56
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 20, p. 8515 - 8537
[5] Patent: WO2012/4706, 2012, A2. Location in patent: Page/Page column 67
2'-hydroxy-5'-(trifluoroMethyl)acetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
2'-hydroxy-5'-(trifluoroMethyl)acetophenone Suppliers
- Tel
- 021-31038972,31038973 17321035817
- Fax
- +86-21-51385350
- sales@harvest-chem.com
- Country
- China
- ProdList
- 2818
- Advantage
- 64
- Tel
- 18986259541 18986259541
- Fax
- 027-87840182
- sales@3stc.com
- Country
- China
- ProdList
- 3744
- Advantage
- 58
- Tel
- 150-2103-5486 18017383231
- Fax
- qq：2817624287
- 983544897@qq.com
- Country
- China
- ProdList
- 9341
- Advantage
- 55
- Tel
- +86-021-50935922
- Fax
- +86-021-33847795
- Country
- China
- ProdList
- 7865
- Advantage
- 55
- Tel
- 029-86115547 17791676824
- Fax
- 02151602123
- sales@cochemical.com
- Country
- China
- ProdList
- 3014
- Advantage
- 58
- Tel
- 400-400-164-7117 18317119277
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 40000
- Advantage
- 60
- Tel
- 0519-85252752 15366845260
- Fax
- 86-0519-85683352
- taihuaren@vip.163.com
- Country
- China
- ProdList
- 1118
- Advantage
- 58
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15114
- Advantage
- 55
- Tel
- 13817485796
- Fax
- QQ:895624079
- tim@wisacheampharm.com
- Country
- China
- ProdList
- 3623
- Advantage
- 58
- Tel
- 021-64340559 13651849907;
- Fax
- 021- 64345308
- xinyu_shi@jwypharmlab.com.cn
- Country
- China
- ProdList
- 12000
- Advantage
- 58