5-Butyl-1H-pyrazole-3-carboxylic acid

Product Name: 5-Butyl-1H-pyrazole-3-carboxylic acid
CAS No.: 92933-48-7
Chemical Name: 5-Butyl-1H-pyrazole-3-carboxylic acid
Synonyms: LUF6283;3-butyl-1H-pyrazole-5-carboxylic acid;5-Butyl-1H-pyrazole-3-carboxylic acid;1H-Pyrazole-3-carboxylic acid, 5-butyl-
CBNumber: CB82647450
Molecular Formula: C8H12N2O2
Formula Weight: 168.19
MOL File: 92933-48-7.mol

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5-Butyl-1H-pyrazole-3-carboxylic acid Property

Melting point:: 166-167 °C
Boiling point:: 385.8±30.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: soluble10mg/mL (clear solution; warmed)
pka: 15.44±0.10(Predicted)
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0441
Product name: LUF6283
Purity: ≥95% (HPLC)
Packaging: 5mg
Price: $97.6
Updated: 2022/05/15

Sigma-Aldrich

Product number: SML0441
Product name: LUF6283
Purity: ≥95% (HPLC)
Packaging: 25mg
Price: $392
Updated: 2022/05/15

Cayman Chemical

Product number: 15423
Product name: LUF6283
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 15423
Product name: LUF6283
Packaging: 25mg
Price: $267
Updated: 2024/03/01

Cayman Chemical

Product number: 15423
Product name: LUF6283
Packaging: 1mg
Price: $32
Updated: 2024/03/01

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5-Butyl-1H-pyrazole-3-carboxylic acid Chemical Properties,Usage,Production

Description

LUF6283 is a partial agonist of GPR109A/HCA₂ G protein-coupled receptors (K_i = 0.55 μM in a radioligand binding assay). It stimulates [³⁵S]-GTPγS binding and increases phosphorylation of ERK in HEK293T cells expressing GPR109A/HCA₂ receptors (EC₅₀s = 3.1 and 0.32 μM, respectively). In vivo, LUF6283 (400 mg/kg per day) reduces plasma levels of VLDL and hepatic expression of apolipoprotein B in mice.

Uses

LUF 6283 is a partial agonist of HCA2 and is a promising drug candidate to achieve a beneficial lipid lowering effect of niacin, ultimately treating dyslipidemic disorders.

in vivo

LUF6283 (C57BL/6 mice, 400 mg/kg, Oral gavage, once a day for 4 weeks) has no effect on adipose tissue ATGL/HSL expression, and significantly reduces the expression of apolipoprotein B (APOB)^[1].

References

[1] ZHAOSHA LI. Effects of pyrazole partial agonists on HCA2-mediated flushing and VLDL-triglyceride levels in mice[J]. British Journal of Pharmacology, 2012, 167 4: 818-825. DOI: 10.1111/j.1476-5381.2012.02039.x

5-Butyl-1H-pyrazole-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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92933-48-7, 5-Butyl-1H-pyrazole-3-carboxylic acidRelated Search:

LUF6283

5-Butyl-1H-pyrazole-3-carboxylic acid

3-butyl-1H-pyrazole-5-carboxylic acid

1H-Pyrazole-3-carboxylic acid, 5-butyl-

92933-48-7