ChemicalBook > CAS DataBase List > 5-Butyl-1H-pyrazole-3-carboxylic acid

5-Butyl-1H-pyrazole-3-carboxylic acid

Product Name
5-Butyl-1H-pyrazole-3-carboxylic acid
CAS No.
92933-48-7
Chemical Name
5-Butyl-1H-pyrazole-3-carboxylic acid
Synonyms
LUF6283;3-butyl-1H-pyrazole-5-carboxylic acid;5-Butyl-1H-pyrazole-3-carboxylic acid;1H-Pyrazole-3-carboxylic acid, 5-butyl-
CBNumber
CB82647450
Molecular Formula
C8H12N2O2
Formula Weight
168.19
MOL File
92933-48-7.mol
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5-Butyl-1H-pyrazole-3-carboxylic acid Property

Melting point:
166-167 °C
Boiling point:
385.8±30.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO: soluble10mg/mL (clear solution; warmed)
pka
15.44±0.10(Predicted)
form 
powder
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0441
Product name
LUF6283
Purity
≥95% (HPLC)
Packaging
5mg
Price
$97.6
Updated
2022/05/15
Sigma-Aldrich
Product number
SML0441
Product name
LUF6283
Purity
≥95% (HPLC)
Packaging
25mg
Price
$392
Updated
2022/05/15
Cayman Chemical
Product number
15423
Product name
LUF6283
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
15423
Product name
LUF6283
Packaging
25mg
Price
$267
Updated
2024/03/01
Cayman Chemical
Product number
15423
Product name
LUF6283
Packaging
1mg
Price
$32
Updated
2024/03/01
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5-Butyl-1H-pyrazole-3-carboxylic acid Chemical Properties,Usage,Production

Description

LUF6283 is a partial agonist of GPR109A/HCA2 G protein-coupled receptors (Ki = 0.55 μM in a radioligand binding assay). It stimulates [35S]-GTPγS binding and increases phosphorylation of ERK in HEK293T cells expressing GPR109A/HCA2 receptors (EC50s = 3.1 and 0.32 μM, respectively). In vivo, LUF6283 (400 mg/kg per day) reduces plasma levels of VLDL and hepatic expression of apolipoprotein B in mice.

Uses

LUF 6283 is a partial agonist of HCA2 and is a promising drug candidate to achieve a beneficial lipid lowering effect of niacin, ultimately treating dyslipidemic disorders.

5-Butyl-1H-pyrazole-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Butyl-1H-pyrazole-3-carboxylic acid Suppliers

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92933-48-7, 5-Butyl-1H-pyrazole-3-carboxylic acidRelated Search:


  • LUF6283
  • 5-Butyl-1H-pyrazole-3-carboxylic acid
  • 3-butyl-1H-pyrazole-5-carboxylic acid
  • 1H-Pyrazole-3-carboxylic acid, 5-butyl-
  • 92933-48-7