ChemicalBook > CAS DataBase List > 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride

Product Name
5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride
CAS No.
720720-96-7
Chemical Name
5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride
Synonyms
4,5,6,7-tetrahydro-5-Methyl-Thiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride;SWF-2;5-Methyl-4;Edoxaban-2;Edoxaban iMpurities 2;Yidu Saban Impurity B;Edoxaban Impurity 4 HCl;Edoxaban Impurity 32 HCl;Edoxaban Impurity B（HCl）;Edoxaban Impurity 12 HCl
CBNumber
CB82655282
Molecular Formula
C8H11ClN2O2S
Formula Weight
234.7
MOL File
720720-96-7.mol
More
Less

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride Property

Melting point:
199.0 to 203.0 °C
Boiling point:
175℃[at 101 325 Pa]
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Aqueous Acid (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Very Slightly)
form 
Solid
color 
Pale Beige to Light Brown
Stability:
Hygroscopic
InChI
InChI=1S/C8H10N2O2S.ClH/c1-10-3-2-5-6(4-10)13-7(9-5)8(11)12;/h2-4H2,1H3,(H,11,12);1H
InChIKey
ZWIYEBIMFPQYDI-UHFFFAOYSA-N
SMILES
C(C1SC2CN(C)CCC=2N=1)(=O)O.Cl
More
Less

Safety

HS Code 
2934.10.2000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
M2819
Product name
5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride
Purity
>97.0%(HPLC)
Packaging
200mg
Price
$24
Updated
2025/07/31
TCI Chemical
Product number
M2819
Product name
5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride
Purity
>97.0%(HPLC)
Packaging
1g
Price
$70
Updated
2025/07/31
TRC
Product number
M330085
Product name
5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride
Packaging
25g
Price
$820
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
66235
Product name
5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylicAcidHCl
Packaging
5G
Price
$675
Updated
2021/12/16
ChemScene
Product number
CS-M3401
Product name
5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride
Packaging
5g
Price
$58
Updated
2021/12/16
More
Less

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride Chemical Properties,Usage,Production

Uses

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is used as a reagent in the synthesis of N-(2-acylaminobenzyl or 2-acylaminoheterocyclylmethyl)thiophene-2-carboxamide derivatives as antithrombotics. It is also used as a reagent in the synthesis of diamide derivatives as FXa inhibitors. 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is an intermediate for Edoxaban (E555520).

Preparation

2-cyano-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine hydrochloride monohydrate (500.61 mg), ethanol (5 mL), and 4N aqueous lithium hydroxide (1.34 mL) were mixed at room temperature, and the resultant mixture was stirred at 50 °C for 7 hours. Until the reaction mixture was cooled with ice-water, 1N HCl in ethanol (7.5 mL) was added to the mixture. It was stirred for 1.5 hours. The precipitated crystals were collected by filtration, and were washed with ethanol (2 mL). The wet crystal was dried at room temperature under reduced pressure to obtain 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride.

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride Suppliers

Americas 1 China 306 Europe 1 India 31 Japan 1 Switzerland 2 United Kingdom 1 United States 9 Global 352
Jiangsu Vcare PharmaTech Co., Ltd.
Tel
025-58741518 13327700685
Fax
+86-25-58744115
Email
sales@vcarepharmatech.com
Country
China
ProdList
308
Advantage
61
Jinan Lide Pharmaceutical Technology Co., Ltd.
Tel
0531-68654990 18560195202
Fax
053168654990
Email
leadgxm@leadchem.net
Country
China
ProdList
174
Advantage
58
Zhongshan Jukemei Biotechnology Co., Ltd.
Tel
13642727863
Email
1009049100@qq.com
Country
China
ProdList
656
Advantage
58
Beijing Lianben Pharm-Chemicals Tech. Co.,Ltd
Tel
010-83386758 18810831598
Fax
010-83386758
Email
sales@lianben.com
Country
China
ProdList
94
Advantage
58
Henan Dongyao Pharmaceutical Technology Co., Ltd
Tel
18519331287; 18519331287
Email
1751713684@qq.com
Country
China
ProdList
220
Advantage
58
Jinan Dexinjia Bio&Tech Co., Ltd
Tel
0531-82371986 15269101859
Fax
0531-82375893
Email
3276840968@qq.com
Country
China
ProdList
1604
Advantage
58
Nanjing Intermate Technology Co., Ltd
Tel
18501091076 18501091076
Email
57715449@qq.com
Country
China
ProdList
63
Advantage
58
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Enantiotech Corporation Ltd
Tel
760-85282375 13212762451
Email
marketing@enantiotech.net
Country
China
ProdList
139
Advantage
55
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
Advantage
64
Changzhou Joyous Chemical Co., Ltd.
Tel
0519-85607258 13912342323;
Fax
0519-85607278
Email
sales@joyouschem.com
Country
China
ProdList
294
Advantage
60
Xi'an Manareco New Materials Co., Ltd.
Tel
029-68669089-8816
Fax
+86-29-68669073
Email
market@xarlm.com
Country
China
ProdList
499
Advantage
55
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5158
Advantage
50
Beijing Yisiyan Technology Research Center
Tel
010-56645598 13366904824
Fax
01062230033
Email
bjkaida@163.com
Country
China
ProdList
1618
Advantage
59
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
ShenZhen InnoSyn Biotech Co.,Ltd
Tel
0755-28351685 18503098468
Fax
+86-755-28466854
Email
innosyn@163.com
Country
China
ProdList
602
Advantage
55
Shanghai Witofly Chemical Co.,Ltd
Tel
Email
sales@witofly.com
Country
China
ProdList
2864
Advantage
52
EnliPharma Technology Co., Ltd
Tel
0551-66399836 18955197623
Email
sales@enlipharma.com
Country
China
ProdList
1876
Advantage
55
AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
15928766785 15928766785
Fax
QQ961458712
Email
wupengcheng@astatech.cn
Country
China
ProdList
1987
Advantage
55
Cangzhou Senary Chemical Science-tech Co., Ltd
Tel
+86-317-3563899
Fax
+86-317-3563199
Email
trade@senary.com
Country
China
ProdList
98
Advantage
56
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Nanjing Credit Trading Co.,Ltd
Tel
025-52164950
Fax
025-86800069
Email
Googlexu_0114@sina.com
Country
China
ProdList
644
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18333
Advantage
56
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883
Fax
0731-82251112
Email
sales@huatengsci.com
Country
China
ProdList
5872
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
Shanghai Synteam Biochem CO.,ltd
Tel
+86-021-58380978 13482386415
Fax
021-58380978
Email
info@systeambc.com
Country
China
ProdList
896
Advantage
50
Sicemo Ltd.
Tel
0532-85625977 13668866880
Email
interchem@foxmail.com
Country
China
ProdList
74
Advantage
55
BEIJING EAGLE SKY PHARMATECH CO., LTD
Tel
010-88755821 13911359480
Email
sophia_818@126.com
Country
China
ProdList
294
Advantage
55
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9858
Advantage
58
Guangzhou Ciming Biological Technology Co., Ltd.
Tel
020-38082199,29065168,38082986,29878298,29866629,4000192398
Fax
+86 (20)38082986
Country
China
ProdList
830
Advantage
60
Shanghai Peiyang Chemical Co., Ltd.
Tel
+86 (21) 61919736
Fax
+86 (21) 61919739
Country
China
ProdList
239
Advantage
55
Intelligence Pharm Science(Shanghai) Co., Ltd.
Tel
021-57898186
Fax
021-37699262
Country
China
ProdList
449
Advantage
55
Anqing CHICO Pharmaceutical Co., Ltd.
Tel
13585175604 13057662806
Fax
+86-25-52261140
Email
sales@chicopharm.com
Country
China
ProdList
499
Advantage
65
Capital Pharmachem Co., Limited
Tel
0371-55613275
Fax
0371-55613283
Email
sales@capitalpharm.com
Country
China
ProdList
39
Advantage
55
SanoChem (Chengdu) Tech. Co., Ltd.
Tel
28-87999436 02887999436
Fax
QQ:2746983436
Email
sales@sano-chem.com
Country
China
ProdList
3795
Advantage
55
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9627
Advantage
58
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
6059
Advantage
65
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9923
Advantage
55
Changzhou Zhichao Chemical Co., Ltd.
Tel
0519-85556809
Fax
0519-85556810
Email
info@wisdomdrugs.com
Country
China
ProdList
213
Advantage
55
DoEasy Pharma Co., Ltd.
Tel
0571-0571-28806358 15397199029
Fax
0571-89057225
Email
songxy@doepharma.com
Country
China
ProdList
82
Advantage
55
Cangzhou Enke Pharma-tech Co., Ltd.
Tel
0317-5296180 15533709196
Fax
0317-5106596
Email
sale@enkepharma.com
Country
China
ProdList
2267
Advantage
55
Nanjing Ally Chemical S&T Co., Ltd.
Tel
025-025-58367986 18913956109
Fax
QQ:3209878052
Email
amy.xiang@ally-chem.com
Country
China
ProdList
567
Advantage
58
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
More
Less

View Lastest Price from 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride manufacturers

Anhuyan (Hainan) Biotechnology Co., LTD
Product
5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride 720720-96-7
Price
US $0.00-0.00/G
Min. Order
1G
Purity
99.99%
Supply Ability
200000T
Release date
2025-06-16
Anhui Ruihan Technology Co., Ltd
Product
5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride 720720-96-7
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2023-09-08
Anhui Ruihan Technology Co., Ltd
Product
5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride 720720-96-7
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2023-09-08

720720-96-7, 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochlorideRelated Search:

EthanediaMide, N1-(5-chlo... Thiazolo[5,4-c]pyridine, 4,5,6,7-tetrahydro-5-methyl- 2-(((1S,2R,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)amino)-2-oxoacetic acid (1R,2R,4S)-2-[(tert-butoxycarbonyl)aMino]-4-[(diMethylaMino)carbonyl]cyclohexyl Methanesulfonate N-(5-Chloropyridin-2-yl)oxalaMic acid ethyl ester edoxaban Edoxaban Edoxaban Impurity 8 Oxalic acid 1-ethyl ester Edoxaban Impurity 29 INDEX NAME NOT YET ASSIGNED Edoxaban-d6 Edoxaban Impurity 16 (1S,3S,4S)-3-AMino-4-hydroxy-cyclohexanecarboxylic acid ethyl ester EthanediaMide iMpurity D EthanediaMide, N1-(5-chlo... EthanediaMide, N1-(5-chloro-2-pyridinyl)-N2-[(1S,2S,4R)-4-[(diMethylaMino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-Methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]aMino]cyclohexyl]- (1S,3R,4S)-4-(2-((5-chloropyridin- 2-yl)amino)-2-oxoacetamido)-3-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexane-1-carboxylic acid

  • 4,5,6,7-tetrahydro-5-Methyl-Thiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride
  • 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride
  • EthanediaMide iMpurity B HCL
  • 5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride
  • Thiazolo[5,4-c]pyridine-2-carboxylic acid, 4,5,6,7-tetrahydro-5-Methyl-, hydrochloride (1:1)
  • 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride(for Edoxaban)
  • 4,5,6,7-tetrahydro-5-Methyl-Thiazolo[5,4-c]pyridin
  • 4,5,6,7-tetrahydro-5-Methyl-Thiazolo[5,4-c]pyridine-2-carboxylic acid HCl
  • Edoxaban Impurity 18 Hydrochloride
  • 5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid,hydrochloride
  • 5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid
  • 4-c]pyridine-2-carboxylic acid hydrochloride
  • 5-Methyl-4
  • Edoxaban iMpurities 2
  • Edoxaban-2
  • 4,5,6,7-tetrahydro-5-methyl-Thiazolo[5,4-c]pyridine-2-carboxylic acid, hydrochloride (1:1)
  • Edoxaban Impurity 32 HCl
  • 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride(For export only)
  • 4,5,6,7-tetrahydro-5-methyl-thiazolo[5,4-c]pyridin-2-carboxylic acid hydrochloride
  • SWF-2
  • Edoxaban side chain 2 hydrochloride
  • 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydroch
  • 4,5,6,7-tetrahydro-5-methyl-Thiazolo[5,4-c]pyridine-2-carbox...
  • 4,5,6,7-tetrahydro-5-Methy-Thiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride
  • N1-(5-chloropyridin-2-yl)-N2-((1S,2R,4S)-4-(dimethylcarbamoyl)-2-(5- methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)oxalamide / Edoxaban free base
  • Yidu Saban Impurity B
  • Edoxaban Impurity B（HCl）
  • Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride
  • Edoxaban Impurity 12 HCl
  • Edoxaban Impurity 4 HCl
  • Edoxaban Impurity 21 HCl
  • 4,5,6,7-Tetrahydro-5-methylthieno[5,4-c]pyridine-2-carboxylicacidhydrochloride
  • Edoxaban Impurity: 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride
  • 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride (Intermediate of Edoxaban mesylate)
  • Trityl Candesartan Cilexetil (Intermediate of Candesartan cilexetil)
  • 6-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride
  • Edoxaban Inter. (Avoid the patent)
  • 4,5,6,7-Tetrahydro-5-methyl-thiazolo[5,4-c]pyridin-2-carboxylic acid HCl
  • 720720-96-7
  • 125529-26-0