TERT-BUTYL METHYL 1H-INDAZOLE-1,6-DICARBOXYLATE

Product Name: TERT-BUTYL METHYL 1H-INDAZOLE-1,6-DICARBOXYLATE
CAS No.: 1126424-50-7
Chemical Name: TERT-BUTYL METHYL 1H-INDAZOLE-1,6-DICARBOXYLATE
Synonyms: TERT-BUTYL METHYL 1H-INDAZOLE-1,6-DICARBOXYLATE;1-tert-Butyl 6-Methyl 1H-indazole-1,6-dicarboxylate;1-o-tert-butyl 6-o-methyl Indazole-1,6-dicarboxylate;1-tert-Butyl, 6-meth l lH-indazole-l,6-dicarboxylate;Indazole-1,6-dicarboxylic acid 1-tert-butyl ester 6-Methyl ester;1H-Indazole-1,6-dicarboxylic acid, 1-(1,1-dimethylethyl) 6-methyl ester
CBNumber: CB82656931
Molecular Formula: C14H16N2O4
Formula Weight: 276.29
MOL File: 1126424-50-7.mol

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TERT-BUTYL METHYL 1H-INDAZOLE-1,6-DICARBOXYLATE Property

storage temp.: 2-8°C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T204923
Product name: 1-tert-Butyl6-Methyl1H-Indazole-1,6-dicarboxylate
Packaging: 100mg
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: Y5726
Product name: tert-Butylmethyl1H-indazole-1,6-dicarboxylate
Packaging: 1g
Price: $169
Updated: 2021/12/16

AK Scientific

Product number: Y5726
Product name: tert-Butylmethyl1H-indazole-1,6-dicarboxylate
Packaging: 5g
Price: $462
Updated: 2021/12/16

Matrix Scientific

Product number: 126253
Product name: 1-tert-Butyl6-methyl1H-indazole-1,6-dicarboxylate
Purity: >95%
Packaging: 1g
Price: $468
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0387438
Product name: 1-TERT-BUTYL-6-METHYL-1H-INDAZOLE-1,6-DICARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $497.21
Updated: 2021/12/16

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TERT-BUTYL METHYL 1H-INDAZOLE-1,6-DICARBOXYLATE Chemical Properties,Usage,Production

Synthesis

24424-99-5

170487-40-8

1126424-50-7

A. General procedure for the synthesis of methyl 1-tert-butoxycarbonyl-1H-indazole-6-carboxylate: methyl 1H-indazole-6-carboxylate (502 mg, 2.84 mmol), 4-dimethylaminopyridine (DMAP, 69 mg, 0.57 mmol), and triethylamine (Et3N, 431 mg, 4.26 mmol) were dissolved in tetrahydrofuran (THF) under cooling in an ice bath (THF, 10 mL). Subsequently, di-tert-butyl dicarbonate (Boc2O, 743 mg, 3.41 mmol) was slowly added to this solution. The reaction mixture was stirred overnight at room temperature. After completion of the reaction, the mixture was concentrated and the residue was extracted with ethyl acetate. The organic phases were combined, concentrated and purified by silica gel column chromatography to afford methyl 1-tert-butoxycarbonyl-1H-indazole-6-carboxylate (797 mg, 100% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 1.74 (9H, s), 3.97 (3H, s), 7.77 (1H, dd, J = 0.4 Hz, J = 8.4 Hz), 7.95 (1H, dd, J = 1.2 Hz, J = 8.4 Hz), 8.21 (1H, d, J = 0.8 Hz), 8.90 (1H s). Mass spectral analysis: calculated value of [M + H]+ (C14H16N2O4) was 277.118 and measured value was 221.

References

[1] Patent: WO2014/89364, 2014, A1. Location in patent: Paragraph 00469; 00470
[2] Patent: WO2009/32125, 2009, A1. Location in patent: Page/Page column 112
[3] Patent: WO2009/32124, 2009, A1. Location in patent: Page/Page column 186-187
[4] Patent: WO2009/152200, 2009, A1. Location in patent: Page/Page column 82

TERT-BUTYL METHYL 1H-INDAZOLE-1,6-DICARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL METHYL 1H-INDAZOLE-1,6-DICARBOXYLATE Suppliers

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1126424-50-7, TERT-BUTYL METHYL 1H-INDAZOLE-1,6-DICARBOXYLATERelated Search:

1-tert-Butyl, 6-meth l lH-indazole-l,6-dicarboxylate

TERT-BUTYL METHYL 1H-INDAZOLE-1,6-DICARBOXYLATE

1-tert-Butyl 6-Methyl 1H-indazole-1,6-dicarboxylate

Indazole-1,6-dicarboxylic acid 1-tert-butyl ester 6-Methyl ester

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