ChemicalBook > CAS DataBase List > L 2-401

L 2-401

Product Name: L 2-401
CAS No.: 883050-24-6
Chemical Name: L 2-401
Synonyms: CS-563;L 2-401;CCG 50014;CCG50014;CCG 50014;CCG-50014 >=98% (HPLC);CCG-50014, 10 mM in DMSO;4-(4-Fluorobenzyl)-2-p-tolyl-1,2,4-thiadiazolidine-3,5-dione;4-[(4-Fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione;1,2,4-Thiadiazolidine-3,5-dione, 4-[(4-fluorophenyl)methyl]-2-(4-methylphenyl)-;Regulators of G-protein Signaling,Regulator of G-protein Signaling,RGS Protein,CCG-50014,inhibit,CCG50014,Inhibitor
CBNumber: CB82657938
Molecular Formula: C16H13FN2O2S
Formula Weight: 316.35
MOL File: 883050-24-6.mol

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L 2-401 Property

Density: 1.398±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL, clear (warmed)
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0908
Product name: CCG-50014
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $106
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0908
Product name: CCG-50014
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $284
Updated: 2025/07/31

Cayman Chemical

Product number: 10802
Product name: CCG-50014
Purity: ≥98%
Packaging: 1mg
Price: $27
Updated: 2024/03/01

Cayman Chemical

Product number: 10802
Product name: CCG-50014
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 10802
Product name: CCG-50014
Purity: ≥98%
Packaging: 10mg
Price: $146
Updated: 2024/03/01

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L 2-401 Chemical Properties,Usage,Production

Description

CCG-50014 is an inhibitor of regulator of G protein signaling 4 (RGS4) (IC₅₀ = 30 nM) and is > 20-fold selective for RGS4 over other RGS proteins. RGS proteins bind to the Gα subunits of activated heterotrimeric G proteins and accelerate the rate of GTP hydrolysis, acting as GTPase-activating proteins. CCG-50014 irreversibly binds and destabilizes RGS4 with no effect on Gα₀, while blocking GTPase activity and Gα₀-dependent translocation of RGS4 to the membrane.

Uses

CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site[1]. CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test[2].

in vivo

CCG50014 (10, 30, or 100 nM) attenuates the nociceptive responses during the late phase in a dose-dependent manner^[2].

IC 50

RGS4: 30 nM (IC₅₀); RGS8: 11 μM (IC₅₀); RGS16: 3.5 μM (IC₅₀); RGS19: 0.12 μM (IC₅₀)

References

[1] Blazer LL, et al. A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins. Biochemistry. 2011 Apr 19;50(15):3181-92. DOI:10.1021/bi1019622
[2] Yoon SY, et al. Intrathecal RGS4 inhibitor, CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test. Anesth Analg. 2015 Mar;120(3):671-7. DOI:10.1213/ANE.0000000000000607

L 2-401 Preparation Products And Raw materials

Raw materials

Preparation Products

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L 2-401 Suppliers

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883050-24-6, L 2-401Related Search:

4-[(4-Fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione

CCG 50014

L 2-401

1,2,4-Thiadiazolidine-3,5-dione, 4-[(4-fluorophenyl)methyl]-2-(4-methylphenyl)-

4-(4-Fluorobenzyl)-2-p-tolyl-1,2,4-thiadiazolidine-3,5-dione

CCG50014;CCG 50014

CS-563

CCG-50014 >=98% (HPLC)

Regulators of G-protein Signaling,Regulator of G-protein Signaling,RGS Protein,CCG-50014,inhibit,CCG50014,Inhibitor

CCG-50014, 10 mM in DMSO

883050-24-6

Inhibitors