3-TrifluoroMethoxy-pyridin-2-ylaMine

Product Name: 3-TrifluoroMethoxy-pyridin-2-ylaMine
CAS No.: 1206981-49-8
Chemical Name: 3-TrifluoroMethoxy-pyridin-2-ylaMine
Synonyms: 2-Amino-3-(trifluoromethoxy)pyridine;3-TrifluoroMethoxy-pyridin-2-ylaMine;2-Pyridinamine, 3-(trifluoromethoxy)-;3-Trifluoromethyoxy-pyridin-2-ylamine
CBNumber: CB82664970
Molecular Formula: C6H5F3N2O
Formula Weight: 178.11
MOL File: 1206981-49-8.mol

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3-TrifluoroMethoxy-pyridin-2-ylaMine Property

storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
Appearance: White to light brown Solid
InChI: InChI=1S/C6H5F3N2O/c7-6(8,9)12-4-2-1-3-11-5(4)10/h1-3H,(H2,10,11)
InChIKey: WCRYAXUZQGCSAO-UHFFFAOYSA-N
SMILES: C1(N)=NC=CC=C1OC(F)(F)F

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P309+P311IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Apolloscientific

Product number: PC421031
Product name: 3-Trifluoromethyoxy-pyridin-2-ylamine
Packaging: 250mg
Price: $127
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-3-2H
Product name: 3-Trifluoromethyoxy-pyridin-2-ylamine
Packaging: 250mg
Price: $189
Updated: 2021/12/16

Apolloscientific

Product number: PC421031
Product name: 3-Trifluoromethyoxy-pyridin-2-ylamine
Packaging: 1g
Price: $255
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-3-2H
Product name: 3-Trifluoromethyoxy-pyridin-2-ylamine
Packaging: 1g
Price: $378
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0365094
Product name: 3-(TRIFLUOROMETHOXY)PYRIDIN-2-AMINE
Purity: 95.00%
Packaging: 250MG
Price: $383.25
Updated: 2021/12/16

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3-TrifluoroMethoxy-pyridin-2-ylaMine Chemical Properties,Usage,Production

Synthesis

1361824-81-8

1206981-49-8

2-Nitro-3-(trifluoromethoxy)pyridine (370 mg, 1.78 mmol) was used as a raw material and dissolved in ethanol (5 mL) under stirring. Subsequently, aqueous ammonium chloride (951 mg, 17.78 mmol, dissolved in 10 mL of water) and iron powder (993 mg, 17.78 mmol) were added to this solution. The reaction mixture was heated to 70 °C and maintained at this temperature for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature, filtered to remove the solids, and the solids were washed with ethyl acetate. The filtrate was concentrated to dryness under vacuum. The residue was diluted with water and extracted with ethyl acetate (3 x 15 mL). The organic layers were combined and dried over anhydrous sodium sulfate and subsequently concentrated to dryness under vacuum. The resulting residue was used directly in the next step of the reaction without further purification (yield: 250 mg, yield: 79%). The product was confirmed by NMR hydrogen spectrum (400 MHz, DMSO-d6): δ 7.93-7.91 (m, 1H), 7.48-7.46 (m, 1H), 6.59-6.56 (m, 1H), 6.35 (brs, 2H).

References

[1] Patent: WO2014/111496, 2014, A1. Location in patent: Page/Page column 120; 121
[2] Patent: WO2015/91889, 2015, A1. Location in patent: Page/Page column 75, 76
[3] Patent: US2015/175619, 2015, A1. Location in patent: Paragraph 0229; 0230

3-TrifluoroMethoxy-pyridin-2-ylaMine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-TrifluoroMethoxy-pyridin-2-ylaMine Suppliers

China 50 India 1 United Kingdom 1 United States 5 Global 57

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1206981-49-8, 3-TrifluoroMethoxy-pyridin-2-ylaMineRelated Search:

3-TrifluoroMethoxy-pyridin-2-ylaMine

3-Trifluoromethyoxy-pyridin-2-ylamine

2-Amino-3-(trifluoromethoxy)pyridine

2-Pyridinamine, 3-(trifluoromethoxy)-

1206981-49-8