c-Met inhibitor 1

Product Name: c-Met inhibitor 1
CAS No.: 1357072-61-7
Chemical Name: c-Met inhibitor 1
Synonyms: CS-1422;c-Met inhibitor;c-Met inhibitor 1;c-Met inhibitor 1, 10 mM in DMSO;c-Met/HGFR,c Met inhibitor 1,c-Met inhibitor 1,inhibit,Inhibitor,cMet inhibitor 1;3-[(2-Methyl-2H-indazol-5-yl)thio]-6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazine;6-(1-METHYL-1H-PYRAZOL-4-YL)-3-((2-METHYL-2H-INDAZOL-5-YL)THIO)-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZINE;1,2,4-Triazolo[4,3-b]pyridazine, 3-[(2-methyl-2H-indazol-5-yl)thio]-6-(1-methyl-1H-pyrazol-4-yl)-
CBNumber: CB82666611
Molecular Formula: C17H14N8S
Formula Weight: 362.41
MOL File: 1357072-61-7.mol

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c-Met inhibitor 1 Property

Density: 1.55±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 20 mg/mL (55.19 mM)
form: Solid
pka: -0.27±0.30(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-1557
Product name: c-Metinhibitor1
Purity: 98.01%
Packaging: 10mg
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-1557
Product name: c-Metinhibitor1
Purity: 98.01%
Packaging: 5mg
Price: $220
Updated: 2021/12/16

AK Scientific

Product number: 3354AH
Product name: 6-(1-Methyl-1H-pyrazol-4-yl)-3-((2-methyl-2H-indazol-5-yl)thio)-[1,2,4]triazolo[4,3-B]pyridazine
Packaging: 10mg
Price: $540
Updated: 2021/12/16

ChemScene

Product number: CS-1557
Product name: c-Metinhibitor1
Purity: 98.01%
Packaging: 50mg
Price: $800
Updated: 2021/12/16

ChemScene

Product number: CS-1557
Product name: c-Metinhibitor1
Purity: 98.01%
Packaging: 100mg
Price: $1350
Updated: 2021/12/16

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c-Met inhibitor 1 Chemical Properties,Usage,Production

Uses

c-Met inhibitor 1 is an inhibitor of the c-Met receptor signaling pathway useful for the treatment of cancer including gastric, glioblastoma, and pancreatic cancer. IC50 value: Target: c-Met More details please refer to Patent WO 2012015677 A1.

Synthesis

1022151-55-8

1150617-94-9

1357072-61-7

Example 1A: Synthesis of 6-(1-methyl-1H-pyrazol-4-yl)-3-((2-methyl-2H-indazol-5-yl)thio)-[1,2,4]triazolo[4,3-b]pyridazine Under nitrogen protection, 6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazine-3-thiol (50 g, 268 mmol) was dissolved in DMF (750 mL), and 5-iodo-2-methyl-2H-indazole (55.5 g, 215.1 mmol), 2-pyridine carboxylic acid (5.5 g, 44.7 mmol), copper(I) iodide (4 g, 21.0 mmol) and cesium carbonate (212.5 g, 652.2 mmol). The reaction mixture was stirred at 100 °C for 10 hours. After the reaction was completed, the mixture was cooled to room temperature, poured into water (2000 mL) and stirred at room temperature for 30 min. The mixture was extracted with mixed solvents (CHCl3/IPA = 3/1, 2L x 2). The organic layers were combined and washed sequentially with mixed solution (25% NH4OH(aq)/brine = 1/4, 800mL), saturated LiCl(aq) (1L) and saturated brine (1.5L × 2). The organic layer was dried with Na2SO4 and concentrated under reduced pressure to give a brown crude solid product. The crude product was ground with ethyl acetate (800 mL) at room temperature for 3 h. The pure product was collected by filtration to afford 6-(1-methyl-1H-pyrazol-4-yl)-3-((2-methyl-2H-indazol-5-yl)thio)-[1,2,4]triazolo[4,3-b]pyridazine (68 g, 87.2% yield) as a white solid.MS (m/z): 363.0 ( M + H).

References

[1] PCT Int. Appl. (2012), WO 2012015677 A1 20120202.

c-Met inhibitor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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c-Met inhibitor 1 Suppliers

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1357072-61-7, c-Met inhibitor 1Related Search:

2-Methylindole

CS-1422

c-Met inhibitor 1

6-(1-METHYL-1H-PYRAZOL-4-YL)-3-((2-METHYL-2H-INDAZOL-5-YL)THIO)-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZINE

3-[(2-Methyl-2H-indazol-5-yl)thio]-6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazine

c-Met inhibitor

1,2,4-Triazolo[4,3-b]pyridazine, 3-[(2-methyl-2H-indazol-5-yl)thio]-6-(1-methyl-1H-pyrazol-4-yl)-

c-Met/HGFR,c Met inhibitor 1,c-Met inhibitor 1,inhibit,Inhibitor,cMet inhibitor 1

c-Met inhibitor 1, 10 mM in DMSO

1357072-61-7

C17H14N8S