SJB2-043
Description- Product Name
- SJB2-043
- CAS No.
- 63388-44-3
- Chemical Name
- SJB2-043
- Synonyms
- SJB2-043;2-Phenylnaphth[2,3-d]oxazole-4,9-dione;2-Phenylnaphtho[2,3-d]oxazole-4,9-dione;Naphth[2,3-d]oxazole-4,9-dione, 2-phenyl-;2-phenylbenzo[f][1,3]benzoxazole-4,9-dione;SJB2-043,inhibit,DUBs,SJB2043,SJB-2-043,SJB2 043,Deubiquitinase,Inhibitor
- CBNumber
- CB82666686
- Molecular Formula
- C17H9NO3
- Formula Weight
- 275.26
- MOL File
- 63388-44-3.mol
SJB2-043 Property
- Melting point:
- >290℃
- Boiling point:
- 495.0±48.0 °C(Predicted)
- Density
- 1.373±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- insoluble in H2O; insoluble in EtOH; ≥4.62 mg/mL in DMSO
- form
- solid
- pka
- -3.87±0.20(Predicted)
- color
- Green to dark green
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A3823
- Product name
- SJB2-043
- Packaging
- 5mg
- Price
- $233
- Updated
- 2021/12/16
- Product number
- A3823
- Product name
- SJB2-043
- Packaging
- 10mM(in 1mL DMSO)
- Price
- $256
- Updated
- 2021/12/16
- Product number
- CS-1650
- Product name
- SJB2-043
- Purity
- 99.25%
- Packaging
- 5mg
- Price
- $280
- Updated
- 2021/12/16
- Product number
- A3823
- Product name
- SJB2-043
- Packaging
- 10mg
- Price
- $355
- Updated
- 2021/12/16
- Product number
- CS-1650
- Product name
- SJB2-043
- Purity
- 99.25%
- Packaging
- 10mg
- Price
- $426
- Updated
- 2021/12/16
SJB2-043 Chemical Properties,Usage,Production
Description
SJB2-043 is a potent USP1 inhibitor that inhibits the activity of native USP1/UAF1 with IC50 of 544 nM.
Biological Activity
sjb2-043 is a novel and potent inhibitor of usp1 with ic50 value of 0.544 μm [1].ubiquitin-specific protease 1 (usp1) is a deubiquitinating enzyme (dub) and is a member of the ubiquitin-specific processing (ubp) family of proteases. it deubiquitinates a protein in the dna repair pathway of the fanconi anemia (fa) [1].in the k562 cell line, sjb2-043 decreased usp1 levels in a dose-dependent way and caused degradation of the id1 protein, which resulted from proteasomal degradation. also, sjb2-043 decreased the levels of id2 and id3 proteins. importantly, knockdown of usp1 inhibited cell growth and increased apoptosis. in primary aml cells, sjb2-043 inactivated usp1 and promoted id 1 degradation. in primary human cord blood cd34+ cells, sjb2-043 in low micromolar levels inhibited cell growth. in hela cells, sjb2-043 increased the levels of ub-fancd2 and ub-pcna. and deubiquitination of fancd2 is an important step in the brca/fanconi anemia (fa) dna repair pathway [1].
References
[1]. helena mistry, grace hsieh, sara s, et al. buhrlage, et al. small molecule inhibitors of usp1 target id1 degradation in leukemic cells. mol cancer ther, 2013, 12(12): 2651-2662.
SJB2-043 Preparation Products And Raw materials
Raw materials
Preparation Products
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