XR9576

Product Name: XR9576
CAS No.: 625375-83-9
Chemical Name: XR9576
Synonyms: XR 9576;XR-9576;XR9576;XR9576 methanesulfonate;Tariquidar methanesulfonate;XR9576 methanesulfonate, hydrate;Tariquidar (Methanesulfonate, hydrate);Tariquidar dimethanesulfonate hexahydrate;Tariquidar methanesulfonate hydrate (XR9576);TARIQUIDAR METHANESULFONATE HYDRATE;XR 9576;XR-9576;N-[2-({4-[2-(6,7-Dimethoxy-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]phenyl}carbamoyl)-4,5-dimethoxyphenyl]-3-quinolinecarboxamide
CBNumber: CB82666691
Molecular Formula: C39H42N4O9S
Formula Weight: 742.84
MOL File: 625375-83-9.mol

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XR9576 Property

storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥56.2 mg/mL in DMSO
form: Powder
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-1260
Product name: Tariquidar(methanesulfonate,hydrate)
Purity: 98.38%
Packaging: 50mg
Price: $290
Updated: 2021/12/16

ApexBio Technology

Product number: A3859
Product name: Tariquidarmethanesulfonate,hydrate
Packaging: 50mg
Price: $293
Updated: 2021/12/16

ChemScene

Product number: CS-1260
Product name: Tariquidar(methanesulfonate,hydrate)
Purity: 98.38%
Packaging: 100mg
Price: $490
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611537
Product name: Tariquidar methanesulfonate hydrate
Packaging: 100mg
Price: $606.9
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611537
Product name: Tariquidar methanesulfonate hydrate
Packaging: 250mg
Price: $912.9
Updated: 2021/12/16

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XR9576 Chemical Properties,Usage,Production

Uses

Tariquidar methanesulfonate, hydrate (XR9576 methanesulfonate, hydrate) is a potent and specific inhibitor of P-glycoprotein (P-gp) with a Kd of 5.1 nM.

in vivo

In mice bearing the intrinsically resistant MC26 colon tumors, coadministration of Tariquidar methanesulfonate, hydrate (XR9576 methanesulfonate, hydrate) potentiates the antitumor activity of Doxorubicin without a significant increase in toxicity; maximum potentiation is observed at 2.5-4.0 mg/kg dosed either i.v. or p.o. In addition, coadministration of Tariquidar (6-12 mg/kg p.o.) fully restores the antitumor activity of Paclitaxel, Etoposide, and Vincristine against two highly resistant MDR human tumor xenografts (2780AD, H69/LX4) in nude mice. Tariquidar is found to also significantly potentiate the antitumor activity of doxorubicin against s.c. MC26 tumors in vivo^[2].

References

[1] Martin C, et al. The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein. Br J Pharmacol, 1999, 128(2), 403-411. DOI:10.1038/sj.bjp.0702807
[2] Mistry P, et al. In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576. Cancer Res, 2001, 61(2), 749-758. PMID:11212278
[3] Vraka C, et al. A new method measuring the interaction of radiotracers with the human P-glycoprotein (P-gp) transporter. Nucl Med Biol. 2018 Feb 14;60:29-36. DOI:10.1016/j.nucmedbio.2018.02.002

XR9576 Preparation Products And Raw materials

Raw materials

Preparation Products

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XR9576 Suppliers

China 24 United States 6 Global 30

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
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Shanghai Jiegu Biotechnology Co., Ltd.

Tel: 021-51698675
Email: sales@jiejiegroup.com
Country: China
ProdList: 8020
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Shanghai Zeye Biotechnology Co., Ltd.

Tel: 021-021-61998551 13122364865
Email: sale1@shzysw.net
Country: China
ProdList: 9778
Advantage: 58

625375-83-9, XR9576Related Search:

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XR 9576;XR-9576;XR9576

TARIQUIDAR METHANESULFONATE HYDRATE;XR 9576;XR-9576

N-[2-({4-[2-(6,7-Dimethoxy-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]phenyl}carbamoyl)-4,5-dimethoxyphenyl]-3-quinolinecarboxamide

Tariquidar (Methanesulfonate, hydrate)

Tariquidar dimethanesulfonate hexahydrate

XR9576 methanesulfonate, hydrate

Tariquidar methanesulfonate hydrate (XR9576)

Tariquidar methanesulfonate

XR9576 methanesulfonate

625375-83-9

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C38H38N4O62CH4O3S6H2O