D-xylo-Pentodialdo-5,2-furanose, 1-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-4,5-O-(1-Methylethylidene)-,(5S)-

Product Name: D-xylo-Pentodialdo-5,2-furanose, 1-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-4,5-O-(1-Methylethylidene)-,(5S)-
CAS No.: 1103738-30-2
Chemical Name: D-xylo-Pentodialdo-5,2-furanose, 1-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-4,5-O-(1-Methylethylidene)-,(5S)-
Synonyms: SOTA-007;EOS-61382;CPD0854-A1;LX4211 N-4;Sotagliflozin N-4;Intermediates for LX4211;Sotagliflozin Impurity 7;LX4211 N-4 Intermediate 9;(4-Chloro-3-(4-ethoxybenzyl)phenyl)((3aS,5R,6S,6aS);(4-chloro-3-(4-ethoxybenzyl)phenyl)((3aS,5R,6S,6aS)-6-hydroxy-
CBNumber: CB82667012
Molecular Formula: C23H25ClO6
Formula Weight: 432.89
MOL File: 1103738-30-2.mol

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D-xylo-Pentodialdo-5,2-furanose, 1-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-4,5-O-(1-Methylethylidene)-,(5S)- Property

Boiling point:: 601.7±55.0 °C(Predicted)
Density: 1.271±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 12?+-.0.60(Predicted)
Appearance: White to off-white Solid
InChIKey: TUBVOYXRJBKZBN-MLNNCEHLSA-N
SMILES: O=C(C1=CC=C(Cl)C(CC2=CC=C(OCC)C=C2)=C1)[C@H]1[C@H]([C@H]2[C@@]([H])(O1)OC(O2)(C)C)O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-M2124
Product name: D-xylo-Pentodialdo-5,2-furanose,1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-4,5-O-(1-methylethylidene)-,(5S)-
Packaging: 250mg
Price: $125
Updated: 2021/12/16

ChemScene

Product number: CS-M2124
Product name: D-xylo-Pentodialdo-5,2-furanose,1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-4,5-O-(1-methylethylidene)-,(5S)-
Packaging: 1g
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-M2124
Product name: D-xylo-Pentodialdo-5,2-furanose,1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-4,5-O-(1-methylethylidene)-,(5S)-
Packaging: 5g
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-M2124
Product name: D-xylo-Pentodialdo-5,2-furanose,1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-4,5-O-(1-methylethylidene)-,(5S)-
Packaging: 10g
Price: $1253
Updated: 2021/12/16

Ambeed

Product number: A233196
Product name: (4-Chloro-3-(4-ethoxybenzyl)phenyl)((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanone
Purity: 97%
Packaging: 250mg
Price: $83
Updated: 2021/12/16

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D-xylo-Pentodialdo-5,2-furanose, 1-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-4,5-O-(1-Methylethylidene)-,(5S)- Chemical Properties,Usage,Production

Synthesis

461432-23-5

1103738-19-7

1103738-30-2

Using 4-(2-chloro-5-bromobenzyl)phenyl ethyl ether (Compound C-1, 10 g, 30.7 mmol) and ((3AS,5R,6S,6AS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone (Compound B, 9.6 g, 35.3 mmol, 1.15 equivalent) as raw material, the general procedure for the synthesis of (4-chloro-3-(4-ethoxybenzyl)phenyl)((3AS,5R,6S,6AS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanone (Compound D-1) was carried out as follows: dissolve Compound C-1 (10 g, 30.7 mmol) in 70 mL of tetrahydrofuran in a 250 mL three-necked flask and stirred until completely dissolved. The solution was cooled to -70 to -80 °C, n-butyllithium solution (2.5 M THF solution, 14.1 mL, 1.15 eq.) was slowly added dropwise and stirred continuously for 1 hour at this temperature. Subsequently, a tetrahydrofuran solution of compound B (9.6 g of B dissolved in 30 mL of tetrahydrofuran) was slowly added dropwise to the reaction mixture. After the dropwise addition was completed, the reaction mixture was continued to be stirred at -70 to -80 °C for 2 hours. After that, the reaction solution was slowly warmed up to -10 to 0 °C and diluted with saturated aqueous NH4Cl solution (20 mL). The reaction mixture was extracted twice with ethyl acetate (100 mL x 2), the organic phases were combined and washed with brine (100 mL). The organic layer was concentrated to dryness under reduced pressure at 40 to 50 °C. The resulting solid was recrystallized by ethyl acetate and hexane to give 11.5 g of compound D-1 in 86.3% yield.

References

[1] Patent: CN108675976, 2018, A. Location in patent: Paragraph 0083; 0084; 0085

D-xylo-Pentodialdo-5,2-furanose, 1-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-4,5-O-(1-Methylethylidene)-,(5S)- Preparation Products And Raw materials

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Preparation Products

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D-xylo-Pentodialdo-5,2-furanose, 1-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-4,5-O-(1-Methylethylidene)-,(5S)- Suppliers

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View Lastest Price from D-xylo-Pentodialdo-5,2-furanose, 1-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-4,5-O-(1-Methylethylidene)-,(5S)- manufacturers

Cangzhou Kangrui Pharma Tech Co. Ltd.,

Product: (5S)-1-C-[4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-4,5-O-(1-methylethylidene)-D-xylo-pentodialdo-5,2-furanose 1103738-30-2
Price: US $0.00-0.00/g
Min. Order: 100g
Purity: 98%
Supply Ability: 13kgs
Release date: 2024-11-19

Career Henan Chemical Co

Product: D-xylo-Pentodialdo-5,2-furanose, 1-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-4,5-O-(1-Methylethylidene)-,(5S)- 1103738-30-2
Price: US $6.00/KG
Min. Order: 1KG
Purity: 95%-98%
Supply Ability: 100
Release date: 2019-09-04

1103738-30-2, D-xylo-Pentodialdo-5,2-furanose, 1-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-4,5-O-(1-Methylethylidene)-,(5S)-Related Search:

(5S)-1-C-[4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-4,5-O-(1-methylethylidene)-D-xylo-pentodialdo-5,2-furanose

Intermediates for LX4211

LX4211 N-4

Sotagliflozin N-4

SOTA-007

D-xylo-Pentodialdo-5,2-furanose, 1-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-4,5-O-(1-Methylethylidene)-,(5S)-

(4-chloro-3-(4-ethoxybenzyl)phenyl)((3aS,5R,6S,6aS)-6-hydroxy-2,2-diMethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)Methanone

(4-chloro-3-(4-ethoxybenzyl)phenyl)((5R,6S)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanone

CPD0854-A1

(4-Chloro-3-(4-ethoxybenzyl)phenyl)((3aS,5R,6S,6aS)-6- hydroxy-2,2-dimethyltetrahydrofuro[3,2-d][1,3]dioxol- 5-yl)methanone

EOS-61382

(4-chloro-3-(4-ethoxybenzyl)phenyl)((3aS,5R,6S,6aS)-6-hydroxy-

D-xylo-Pentodialdo-5,2-furanose,1-C-[4-chloro-3-[(4-ethoxyph...

TIANFU CHEM D-xylo-Pentodialdo-5,2-furanose, 1-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-4,5-O-(1-Methylethylidene)-,(5S)-

(4-Chloro-3-(4-ethoxybenzyl)phenyl)((3aS,5R,6S,6aS)

LX4211 N-4 Intermediate 9

Sotagliflozin Impurity 7

(3-(4-ethoxybenzyl)-4-chlorophenyl)((3aS,5R,6S,6aS)-tetrahydro-6-hydroxy-2,2-dimethylfuro[3,2-d][1,3]dioxol-5-yl)methanone ketone threosee

1103738-30-2