ChemicalBook > CAS DataBase List > Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide

Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide

Product Name: Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide
CAS No.: 325970-71-6
Chemical Name: Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide
Synonyms: L67 >=98% (HPLC);L67, 10 mM in DMSO;DNA LIGASE INHIBITOR; L-67; L 67;Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide
CBNumber: CB82668145
Molecular Formula: C16H14Br2N4O4
Formula Weight: 486.11
MOL File: 325970-71-6.mol

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Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide Property

storage temp.: Store at -20°C
solubility: DMSO:21.5(Max Conc. mg/mL);44.23(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);20.57(Max Conc. mM)
Water:1.0(Max Conc. mg/mL);2.06(Max Conc. mM)
form: A crystalline solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1797
Product name: L67
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $126
Updated: 2025/07/31

Cayman Chemical

Product number: 22941
Product name: L67
Purity: ≥98%
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 22941
Product name: L67
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

Cayman Chemical

Product number: 22941
Product name: L67
Purity: ≥98%
Packaging: 25mg
Price: $433
Updated: 2024/03/01

Cayman Chemical

Product number: 22941
Product name: L67
Purity: ≥98%
Packaging: 50mg
Price: $721
Updated: 2024/03/01

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Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide Chemical Properties,Usage,Production

Description

L67 is a competitive inhibitor of DNA ligases I and III (IC₅₀s = 10 and 10 μM for human DNA ligase I and human ligase IIIβ). It blocks DNA binding (K_i = 10 μM), increasing the cytotoxicity of DNA-damaging agents. It also inhibits mitochondrial DNA ligase IIIα and induces the production of reactive oxygen species (ROS) and apoptosis in cancerous, but not non-malignant, cells. It does not inhibit DNA ligase IV or T4 DNA ligase at concentrations up to 100 μM.

Uses

L 67 is used in the identification and validation of human DNA ligase inhibitors using computer-aided grug design.

IC 50

DNA ligases I: 10 μM (IC₅₀); DNA ligases III: 10 μM (IC₅₀); Caspase-1

References

[1] XI CHEN. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair.[J]. Cancer research, 2008: 3169-3177. DOI: 10.1158/0008-5472.can-07-6636
[2] ANNAHITA SALLMYR. Inhibiting Mitochondrial DNA Ligase IIIα Activates Caspase 1-Dependent Apoptosis in Cancer Cells.[J]. ACS Chemical Health & Safety, 2016: 5431-5441. DOI: 10.1158/0008-5472.can-15-3243

Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

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Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide Suppliers

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325970-71-6, Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazideRelated Search:

Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide

DNA LIGASE INHIBITOR; L-67; L 67

L67 >=98% (HPLC)

L67, 10 mM in DMSO

325970-71-6

C16H14Br2N4O4