ChemicalBook > CAS DataBase List > ADH 1

ADH 1

Product Name: ADH 1
CAS No.: 229971-81-7
Chemical Name: ADH 1
Synonyms: ADH 1;Exherin;CS-2142;Exherin TFA;ADH-1 Exherin;Exherin (ADH-1);L-Cysteinamide, N-acetyl-L-cysteinyl-L-histidyl-L-alanyl-L-valyl-, cyclic (1→5)-disulfide;(4R,7S,10S,13S,16R)-13-((1H-Imidazol-5-yl)methyl)-16-acetamido-7-isopropyl-10-methyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetraazacycloheptadecane-4-carboxamide
CBNumber: CB82668226
Molecular Formula: C22H34N8O6S2
Formula Weight: 570.69
MOL File: 229971-81-7.mol

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ADH 1 Property

Boiling point:: 1183.4±65.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: DMSO:2.2(Max Conc. mg/mL);3.86(Max Conc. mM)
form: A solid
pka: 13.13±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29981
Product name: ADH-1
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 29981
Product name: ADH-1
Packaging: 25mg
Price: $533
Updated: 2024/03/01

Cayman Chemical

Product number: 29981
Product name: ADH-1
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 29981
Product name: ADH-1
Packaging: 10mg
Price: $243
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: API0005208
Product name: EXHERIN
Purity: 95.00%
Packaging: 5MG
Price: $282.7
Updated: 2021/12/16

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ADH 1 Chemical Properties,Usage,Production

Uses

ADH-1, an N-cadherin antagonist, inhibits N-cadherin mediated cell adhesion.

Biological Activity

ADH-1 is an N-cadherin (CD325; NCAD) antagonist th at selectively inhibits NCAD-dependent neurite outgrowth (IC50 = 323 μM; PN1-2 r at cerebral neurons on monolayer of chick NCAD-expressing 3T3), while exhibiting no effect against integrin receptor-dependent neurite outgrowth. ADH-1 inhibits NCAD-mediated signaling events in cultures (0.2-2.5 mg/mL) and exhibits anti-tumor efficacy in vivo (50-100 mg/kg i.p. in rats and mice).

in vivo

ADH-1 (50 mg/kg) significantly prevents tumor growth and metastasis in a mouse model for pancreatic cancer. ADH-1 prevents tumor cell invasion and metastasis in an orthotopic model for pancreatic cancer using N-cadherin overexpressing BxPC-3 cells^[1].
ADH-1, at the dosages evaluated, does not display either antiangiogenic activity in a rat aortic ring assay or antitumor potential in a PC3 subcutaneous xenograft tumor model^[2].
In A375, but not DM443 xenografts, ADH-1 treatment increases phosphorylation of AKT at serine 473. ADH-1 slightly diminishes N-cadherin expression in both xenografts^[3].

References

[1] Shintani Y, et al. ADH-1 suppresses N-cadherin-dependent pancreatic cancer progression. Int J Cancer. 2008 Jan 1;122(1):71-7. DOI:10.1002/ijc.23027
[2] Li H, et al. ADH1, an N-cadherin inhibitor, evaluated in preclinical models of angiogenesis and androgen-independent prostate cancer. Anticancer Drugs. 2007 Jun;18(5):563-8. DOI:10.1097/CAD.0b013e328020043e
[3] Turley RS, et al. Targeting N-cadherin increases vascular permeability and differentially activates AKT in melanoma. Ann Surg. 2015 Feb;261(2):368-77 DOI:10.1097/SLA.0000000000000635

ADH 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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ADH 1 Suppliers

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View Lastest Price from ADH 1 manufacturers

Career Henan Chemical Co

Product: ADH 1 229971-81-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-16

Career Henan Chemical Co

Product: ADH 1 229971-81-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-16

229971-81-7, ADH 1Related Search:

ADH 1

Exherin

Exherin TFA

Exherin (ADH-1)

ADH-1 Exherin

CS-2142

L-Cysteinamide, N-acetyl-L-cysteinyl-L-histidyl-L-alanyl-L-valyl-, cyclic (1→5)-disulfide

(4R,7S,10S,13S,16R)-13-((1H-Imidazol-5-yl)methyl)-16-acetamido-7-isopropyl-10-methyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetraazacycloheptadecane-4-carboxamide

229971-81-7

C22H34N8O6S2

Inhibitors

API