ChemicalBook > CAS DataBase List > 4-tert-butyl-2-chloropyridine

4-tert-butyl-2-chloropyridine

Uses

Product Name: 4-tert-butyl-2-chloropyridine
CAS No.: 81167-60-4
Chemical Name: 4-tert-butyl-2-chloropyridine
Synonyms: 2-chloro-4-tert-butylpyride;2-Chloro-4-tert-butylpyridine;4-tert-butyl-2-chloropyridine;4-(tert-Butyl)-2-chloropyridine;2-chloro-4-(1,1-dimethylethyl)-Pyridine;Pyridine, 2-chloro-4-(1,1-dimethylethyl)-;(2-Bromo-5-methoxy-27-methyl-phenyl)-methano;4-tert-butyl-2-chloropyridine4-tert-butyl-2-chloropyridine
CBNumber: CB82668736
Molecular Formula: C9H12ClN
Formula Weight: 169.65
MOL File: 81167-60-4.mol

Less

4-tert-butyl-2-chloropyridine Property

Boiling point:: 223.8±20.0 °C(Predicted)
Density: 1.051±0.06 g/cm3(Predicted)
refractive index: 1.5130 to 1.5170
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: clear liquid
pka: 1.04±0.10(Predicted)
color: Colorless to Almost colorless
InChI: InChI=1S/C9H12ClN/c1-9(2,3)7-4-5-11-8(10)6-7/h4-6H,1-3H3
InChIKey: UGGNULHQVUWRGQ-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=CC(C(C)(C)C)=C1

Less

Safety

HS Code: 2933399990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: B5466
Product name: 4-(tert-Butyl)-2-chloropyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $151
Updated: 2025/07/31

TCI Chemical

Product number: B5466
Product name: 4-(tert-Butyl)-2-chloropyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $516
Updated: 2025/07/31

TRC

Product number: B814068
Product name: 4-(tert-Butyl)-2-chloropyridine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-5-LQ
Product name: 4-tert-Butyl-2-chloropyridine
Purity: 95.0%
Packaging: 500mg
Price: $184
Updated: 2021/12/16

Chem-Impex

Product number: 44691
Product name: 4-(tert-Butyl)-2-chloropyridine,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 1G
Price: $208
Updated: 2021/12/16

Less

4-tert-butyl-2-chloropyridine Chemical Properties,Usage,Production

Uses

4-(tert-butyl)-2-chloropyridine is used as an intermediate in organic synthesis.

Synthesis

23569-17-7

81167-60-4

General procedure for the synthesis of 4-(tert-butyl)-2-chloropyridine from 4-tert-butylpyridine 1-oxide: 4-tert-butylpyridine 1-oxide (5 g, 33.07 mmol) was placed in a two-necked flask. The double-necked flask was cooled in an ice bath and 25 ml of phosphoryl chloride (POCl3) was slowly added to the double-necked flask to form a reaction mixture. The mixture was heated under reflux conditions for 24 hours to complete the reaction. After completion of the reaction, the temperature was slowly reduced to 20°C and the solvent was removed by distillation under reduced pressure. The reaction mixture was neutralized by adding aqueous sodium carbonate solution to a two-necked flask, followed by extraction of the reaction mixture with ethyl acetate and collection of the organic layer. The organic layer was dried over anhydrous sodium sulfate (Na2SO4) to give the crude product. The crude product was purified by column chromatography (silica gel as stationary phase, eluent ratio of ethyl acetate: n-hexane = 1:6) to give 4-(tert-butyl)-2-chloropyridine (4 g, 72% yield) as a clear liquid. The structure of the compound was confirmed by 1H-NMR (400 MHz, CDCl3): δ8.27 (d, J=5.3 Hz, 1H), 7.28 (s, 1H), 7.19 (dd, J=5.2 Hz, 1.6 Hz, 1H), 1.29 (s, 9H).

References

[1] Organometallics, 2011, vol. 30, # 24, p. 6751 - 6765
[2] Synthesis (Germany), 2013, vol. 45, # 22, p. 3099 - 3102
[3] Patent: US9219237, 2015, B1. Location in patent: Page/Page column 13
[4] Patent: WO2012/41476, 2012, A1. Location in patent: Page/Page column 52
[5] Inorganica Chimica Acta, 2012, vol. 383, p. 316 - 319

4-tert-butyl-2-chloropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

Less

4-tert-butyl-2-chloropyridine Suppliers

Americas 1 China 86 Europe 1 Germany 1 India 4 Japan 1 Switzerland 2 United States 9 Global 105

Established by Hangzhou Boman Biochem Tech Co., Ltd

Tel: 13588048971
Email: sales@bomanbiochem.com
Country: China
ProdList: 476
Advantage: 58

Zhejiang ChemPacific Chemical Co., Ltd.

Tel: 573-85576095 13567311134
Email: jiazhang@chempacific.com
Country: China
ProdList: 52
Advantage: 58

Tetranov Biopharm

Tel: 13526569071
Email: sales@leadmedpharm.com
Country: China
ProdList: 7892
Advantage: 64

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4999
Advantage: 60

Shanghai potentpharm CO.,Ltd

Tel: 13524892556
Fax: (86) 21 51969655， QQ： 263541193
Email: sales-cn@potentpharm.com
Country: China
ProdList: 1011
Advantage: 55

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

Zhengzhou HQ Material Co., Ltd.

Tel: 0371-67759225 13526468238
Fax: +86-37155919558
Email: sales@hqmat.com
Country: China
ProdList: 510
Advantage: 60

Cochemical Ltd.

Tel: 029-86115547 17791676824
Fax: 02151602123
Email: sales@cochemical.com
Country: China
ProdList: 3014
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Chongqing Xingcan Pharmaceutical Technology Co., Ltd.

Tel: 023-13650506873 19923294409
Email: xingcanyaoye@sina.com
Country: China
ProdList: 1604
Advantage: 58

Zhengzhou TRIZ Pharmaceutical Technology Co., Ltd.

Tel: 19943855286
Fax: 0371-53392065
Email: triz-4@trizpharma.cn
Country: China
ProdList: 1936
Advantage: 56

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 16679
Advantage: 50

SanoChem (Chengdu) Tech. Co., Ltd.

Tel: 28-87999436 02887999436
Fax: QQ:2746983436
Email: sales@sano-chem.com
Country: China
ProdList: 3795
Advantage: 55

Zhengzhou HQ Material Co., Ltd.

Tel: 0371-0371-67759225 13526468238
Fax: 0371-55919558
Email: sales@hqmat.com
Country: China
ProdList: 342
Advantage: 55

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 7218
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Nanjing SynTitan Pharmaceutical Co., Ltd.

Tel: 025-57027686 17372956142
Fax: 025-57027686
Email: li_lan@syntitan.com
Country: China
ProdList: 9998
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Cool Pharm, Ltd

Tel: 021-58581007 18019463053
Fax: 021-50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12878
Advantage: 58

TCI Chemicals

Tel: 021-67121386, 800-988-0390
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 5391
Advantage: 58

Suzhou Rovathin Foreign Trade Co.,Ltd

Tel: 0512-65816829 18662214788
Fax: 0512-65816829
Email: info@rovathin.com.cn
Country: China
ProdList: 9987
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

Nextpeptide Inc

Tel: +86-0571-81612335 +8613336028439
Email: sales@nextpeptide.com
Country: China
ProdList: 19908
Advantage: 58

CD Chemical Group Limited

Tel: +8615986615575
Fax: 0086-13651442114
Email: info@codchem.com
Country: China
ProdList: 20342
Advantage: 58

ZHEJIANG CHEMPACIFIC CHEMICAL CO.,LTD

Tel: +86-13586356488 13586348435
Fax: +86-0573-85576068
Email: sales@chempacific.com
Country: CHINA
ProdList: 88
Advantage: 58

Amel Pharmatech Corporation

Tel: 027-888-4366503
Fax: 888-502-1736
Email: sales@amelpharmatech.com
Country: China
ProdList: 5000
Advantage: 58

Wuhan Ying Yuan Bei Biological Limited

Tel: 13349903920 13349903920;
Email: 1540154086@qq.com
Country: China
ProdList: 3004
Advantage: 58

Changzhou Yinghao Technology Development Co., Ltd

Tel: 15151934985
Email: sales@yingsapharm.com
Country: China
ProdList: 5181
Advantage: 58

Shanghai jingkang bioengineering co., ltd.

Tel: 021-54721350 13524668266
Fax: 021-5
Email: 2881505714@qq.com
Country: China
ProdList: 7872
Advantage: 58

Shanghai Minhan Pharmaceutical Technology Co., Ltd.

Tel: 17612188245
Fax: QQ 2816925681
Email: 2816925681@qq.com
Country: China
ProdList: 2989
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Richest Group Ltd

Tel: 18017061086
Email: oled@richest-group.com
Country: CHINA
ProdList: 5600
Advantage: 58

Shanghai Joiny Pharmaceutical Co.,Ltd.

Tel: 13681955282
Email: gyd@joiny-pharma.com
Country: China
ProdList: 391
Advantage: 58

Antai Fine Chemical Technology Co.,Limited

Tel: 18503026267
Email: info@antaichem.com
Country: CHINA
ProdList: 9636
Advantage: 58

Taizhou Nanfeng Pharmaceutical Research Institute

Tel: nanfengdrug@163.com; 18616377689
Email: nanfengdrug@163.com
Country: China
ProdList: 20009
Advantage: 58

Jiaxing Hengrui Biotechnology Co. LTD

Tel: 0573-0573-82672231 13757365595
Fax: QQ：715584339
Email: regen_chemical1@163.com
Country: China
ProdList: 4839
Advantage: 58

Suzhou QIHANG Biotechnology Co., Ltd

Tel: 18662190603
Email: 437347250@qq.com
Country: China
ProdList: 4674
Advantage: 58

Shandong Xuchen Chemical Technology Co. Ltd

Tel: 0533-13853380-763 13853380763
Email: 3523649491@qq.com
Country: China
ProdList: 738
Advantage: 58

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-59207852 13308628970
Fax: QQ:2779667926
Email: buy@fortunachem.com
Country: China
ProdList: 2666
Advantage: 58

Nanjing houxiu Pharmaceutical Technology Co., Ltd

Tel: 15252458249
Email: 323325018@qq.com
Country: China
ProdList: 1168
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

WUHAN JIXINYIBANG BIOTECHNOLOGY .,LTD

Tel: 027-59768661 13297943853
Email: 1704244976@qq.com
Country: China
ProdList: 4988
Advantage: 58

Shaanxi Yudingzhuo Medical Technology Co., Ltd.

Tel: 18992018580 18165105898
Fax: QQ:1617857088
Email: 13608210612@163.com
Country: China
ProdList: 2983
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39665
Advantage: 58

Shaanxi DIDU pharmaceutical and Chemical Co., Ltd

Tel: 029-029-029-81148696 18161915376
Email: 1040@dideu.com
Country: China
ProdList: 10001
Advantage: 58

Jiangsu Pules Bio-tech Co.,Ltd

Tel: 0513-66017706 18551496367
Email: 2186883463@qq.com
Country: China
ProdList: 5000
Advantage: 58

Less

View Lastest Price from 4-tert-butyl-2-chloropyridine manufacturers

Zhengzhou HQ Material CO.,LTD.

Product: 4-tert-butyl-2-chloropyridine 81167-60-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10
Release date: 2021-12-15

Career Henan Chemical Co

Product: 4-tert-butyl-2-chloropyridine 81167-60-4
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100g , 1kg, 5kg , 50kg
Release date: 2020-01-07

81167-60-4, 4-tert-butyl-2-chloropyridineRelated Search:

4-tert-butyl-2-chloropyridine

4-tert-butyl-2-chloropyridine4-tert-butyl-2-chloropyridine

4-(<i>tert</i>-Butyl)-2-chloropyridine

2-chloro-4-tert-butylpyride

2-chloro-4-(1,1-dimethylethyl)-Pyridine

Pyridine, 2-chloro-4-(1,1-dimethylethyl)-

(2-Bromo-5-methoxy-27-methyl-phenyl)-methano

2-Chloro-4-tert-butylpyridine

81167-60-4