ChemicalBook > CAS DataBase List > 1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone

1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone

Product Name
1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone
CAS No.
228572-69-8
Chemical Name
1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone
Synonyms
2’-Hydroxy-4’-(trifluoromethyl)acetophenone;2'-Hydroxy-4'-(trifluoromethyl)acetophenone;1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone;Ethanone, 1-[2-hydroxy-4-(trifluoromethyl)phenyl]-;1-[2-Hydroxy-4-(trifluoromethyl)phenyl]ethan-1-one;1-[2-hydroxy-4-(trifluoromethyl)phenyl]ethanone - [H85387]
CBNumber
CB82671644
Molecular Formula
C9H7F3O2
Formula Weight
204.15
MOL File
228572-69-8.mol
More
Less

1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone Property

storage temp. 
2-8°C
Appearance
Colorless to light yellow Liquid
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
H877135
Product name
1-(2-Hydroxy-4-trifluoromethyl-phenyl)-ethanone
Packaging
50mg
Price
$65
Updated
2021/12/16
SynQuest Laboratories
Product number
2829-3-09
Product name
1-[2-Hydroxy-4-(trifluoromethyl)phenyl]ethan-1-one
Purity
97%
Packaging
250mg
Price
$311
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0356436
Product name
1-(2-HYDROXY-4-TRIFLUOROMETHYL-PHENYL)ETHANONE
Purity
95.00%
Packaging
5MG
Price
$505.7
Updated
2021/12/16
AK Scientific
Product number
9409AH
Product name
1-(2-Hydroxy-4-(trifluoromethyl)phenyl)ethanone
Packaging
1g
Price
$532
Updated
2021/12/16
SynQuest Laboratories
Product number
2829-3-09
Product name
1-[2-Hydroxy-4-(trifluoromethyl)phenyl]ethan-1-one
Purity
97%
Packaging
1g
Price
$848
Updated
2021/12/16
More
Less

1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone Chemical Properties,Usage,Production

Synthesis

59938-06-6

123-54-6

228572-69-8

General procedure for the synthesis of 1-(2-hydroxy-4-(trifluoromethyl)phenyl)ethanone from (E)-1-ethoxy-3-trifluoromethyl-1,3-butadiene and acetylacetone: at 0 °C, 4-ethoxy-1,1,1-trifluoro-3-buten-2-one (5 g, 29.7 mmol) and 2,4-pentanedione (3.05 mL, 29.7 mmol) were were added sequentially to a suspension of THF (120 mL) containing NaH (2.38 g, 59.4 mmol). The reaction mixture was refluxed for 4 h and subsequently partitioned with 1N HCl and EtOAc. The organic layer was washed with brine, dried over Na2SO4 and concentrated to give a red oil. Purification by fast column chromatography (eluent: hexane solution with 0 to 10% EtOAc) afforded 1-(2-hydroxy-4-(trifluoromethyl)phenyl)ethanone as a yellow oil (1.73 g, 29% yield).1H NMR (400 MHz, CDCl3): δ 2.69 (s, 3H), 7.15 (d, J = 9.9 Hz, 1H). 7.25 (s, 1H), 7.86 (d, J = 8.3 Hz, 1H), 12.29 (s, 1H).

References

[1] Patent: WO2004/74270, 2004, A2. Location in patent: Page 192
[2] Dalton Transactions, 2014, vol. 43, # 10, p. 4127 - 4136

1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone Suppliers

China 32 India 1 United States 2 Global 35
SuZhou ShiYa Biopharmaceuticals, Inc.
Tel
86(512)5235 8471 17715136450
Fax
86(512)5235 6881
Email
sales@shiyabiopharm.com
Country
China
ProdList
4169
Advantage
58
Shanghai AQBioPharma Co., Ltd.
Tel
13661411401
Fax
51370935-8011
Email
yinglv.que@aqbiopharma.com.cn
Country
China
ProdList
2930
Advantage
58
Hangzhou Milestone Pharmtech Co., Ltd.
Tel
0571-82896630 18969958410
Email
sales_hz@milestonepharmtech.com
Country
China
ProdList
4894
Advantage
55
JW & Y Pharmlab Co., Ltd.
Tel
021-64340559 13651849907;
Fax
021- 64345308
Email
xinyu_shi@jwypharmlab.com.cn
Country
China
ProdList
12000
Advantage
58
BePharm Ltd
Tel
400-685-9117
Fax
021-51816740
Email
market@bepharm.com
Country
China
ProdList
15081
Advantage
60
Nanjing Nohon Biological Technology Co., Ltd.
Tel
025-85767923 18512596075
Fax
025-85767923
Email
sales@nuoxibio.com
Country
China
ProdList
960
Advantage
55
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718; +8613336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29735
Advantage
60
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
16027
Advantage
58
Suzhou Xiya Pharmaceutical Co., Ltd.
Tel
0512-87819718 18912655635
Email
2587879032@qq.com
Country
China
ProdList
1401
Advantage
58
Hefei Molake Biotechnology Co., Ltd.
Tel
0551-66336380 18956014586
Fax
055166336380
Email
983438788@qq.com
Country
China
ProdList
2297
Advantage
58

228572-69-8, 1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanoneRelated Search:


  • 1-(2-Hydroxy-4-trifluoroMethyl-phenyl)-ethanone
  • 2'-Hydroxy-4'-(trifluoromethyl)acetophenone
  • 1-[2-Hydroxy-4-(trifluoromethyl)phenyl]ethan-1-one
  • Ethanone, 1-[2-hydroxy-4-(trifluoromethyl)phenyl]-
  • 2’-Hydroxy-4’-(trifluoromethyl)acetophenone
  • 1-[2-hydroxy-4-(trifluoromethyl)phenyl]ethanone - [H85387]
  • 228572-69-8