4-AMino-1-(1-Boc-4-piperidyl)pyrazole

Product Name: 4-AMino-1-(1-Boc-4-piperidyl)pyrazole
CAS No.: 1029413-55-5
Chemical Name: 4-AMino-1-(1-Boc-4-piperidyl)pyrazole
Synonyms: 4-AMino-1-(1-Boc-4-piperidyl)pyrazole;1-Boc-4-(4-amino-1H-pyrazol-1-yl)piperidine;tert-butyl 4-(4-aminopyrazol-1-yl)piperidine-1-carboxylate;4-(4-amino-pyrazol-1-yl)-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-(4-amino-1H-pyrazol-1-yl)-, 1,1-dimethylethyl ester
CBNumber: CB82676083
Molecular Formula: C13H22N4O2
Formula Weight: 266.34
MOL File: 1029413-55-5.mol

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4-AMino-1-(1-Boc-4-piperidyl)pyrazole Property

Boiling point:: 426.4±35.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 4.31±0.19(Predicted)
Appearance: Brown to reddish brown Solid
InChI: InChI=1S/C13H22N4O2/c1-13(2,3)19-12(18)16-6-4-11(5-7-16)17-9-10(14)8-15-17/h8-9,11H,4-7,14H2,1-3H3
InChIKey: TVJWTRPGFVNAJI-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(N2C=C(N)C=N2)CC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: A594065
Product name: 4-Amino-1-(1-Boc-piperidin-4-yl)-1H-pyrazole
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: A594065
Product name: 4-Amino-1-(1-Boc-piperidin-4-yl)-1H-pyrazole
Packaging: 250mg
Price: $50
Updated: 2021/12/16

TRC

Product number: A594065
Product name: 4-Amino-1-(1-Boc-piperidin-4-yl)-1H-pyrazole
Packaging: 1g
Price: $100
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-698
Product name: tert-Butyl 4-(4-amino-1H-pyrazol-1-yl)piperidine-1-carboxylate
Purity: 97.0%
Packaging: 250mg
Price: $115
Updated: 2021/12/16

AK Scientific

Product number: 7704AC
Product name: tert-Butyl4-(4-amino-1H-pyrazol-1-yl)piperidine-1-carboxylate
Packaging: 5g
Price: $357
Updated: 2021/12/16

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4-AMino-1-(1-Boc-4-piperidyl)pyrazole Chemical Properties,Usage,Production

Uses

4-Amino-1-(1-Boc-piperidin-4-yl)-1H-pyrazole is used as a reactant in the preparation of pyrazolyl-substituted diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases.

Synthesis

1201916-87-1

1029413-55-5

Step 3) tert-butyl 4-(4-nitro-1H-pyrazol-1-yl)piperidine-1-carboxylate (1.35 g, 4.56 mmol) was dissolved in ethanol (30 mL), and Pd/C catalyst (135 mg, 1.269 mmol, mass % = 10%) was added. The reaction mixture was stirred for 2 hours at room temperature under hydrogen atmosphere. After completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under vacuum. The residue was purified by silica gel column chromatography with dichloromethane/methanol as eluent (v/v=50/1 to 25/1) to afford the title product tert-butyl 4-(4-amino-1H-pyrazol-1-yl)piperidine-1-carboxylate as a brown oil (955 mg, 78.7% yield). lc-MS (ESI, cationic) m/z: 211.1 [M-55]+.

References

[1] Patent: WO2017/44434, 2017, A1. Location in patent: Paragraph 0409
[2] Patent: WO2017/48675, 2017, A1. Location in patent: Paragraph 0456
[3] Patent: CN106478651, 2017, A. Location in patent: Paragraph 1004; 1005; 1006
[4] Patent: CN106478607, 2017, A. Location in patent: Paragraph 0673; 0674; 0675
[5] Patent: WO2015/123722, 2015, A1. Location in patent: Page/Page column 90

4-AMino-1-(1-Boc-4-piperidyl)pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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4-AMino-1-(1-Boc-4-piperidyl)pyrazole Suppliers

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1029413-55-5, 4-AMino-1-(1-Boc-4-piperidyl)pyrazoleRelated Search:

4-AMino-1-(1-Boc-4-piperidyl)pyrazole

1-Boc-4-(4-amino-1H-pyrazol-1-yl)piperidine

tert-butyl 4-(4-aminopyrazol-1-yl)piperidine-1-carboxylate

1-Piperidinecarboxylic acid, 4-(4-amino-1H-pyrazol-1-yl)-, 1,1-dimethylethyl ester

4-(4-amino-pyrazol-1-yl)-piperidine-1-carboxylic acid tert-butyl ester

1029413-55-5