Ethyl 2-(4-broMopyridin-2-yl)acetate
- Product Name
- Ethyl 2-(4-broMopyridin-2-yl)acetate
- CAS No.
- 1060814-91-6
- Chemical Name
- Ethyl 2-(4-broMopyridin-2-yl)acetate
- Synonyms
- Ethyl 2-(4-Bromo-2-pyridyl)acetate;2-Pyridineacetic acid, 4-bromo-, ethyl ester;(4-Bromo-pyridin-2-yl)-acetic acid ethyl ester
- CBNumber
- CB82676795
- Molecular Formula
- C9H10BrNO2
- Formula Weight
- 244.09
- MOL File
- 1060814-91-6.mol
Ethyl 2-(4-broMopyridin-2-yl)acetate Property
- Boiling point:
- 294.4±25.0 °C(Predicted)
- Density
- 1.451±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.87±0.10(Predicted)
- Appearance
- Light yellow to yellow Liquid
- InChI
- InChI=1S/C9H10BrNO2/c1-2-13-9(12)6-8-5-7(10)3-4-11-8/h3-5H,2,6H2,1H3
- InChIKey
- UNQUMGSSWNEUIM-UHFFFAOYSA-N
- SMILES
- C1(CC(OCC)=O)=NC=CC(Br)=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E938225
- Product name
- Ethyl2-(4-Bromopyridin-2-yl)acetate
- Packaging
- 10mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CS-W020454
- Product name
- Ethyl2-(4-bromopyridin-2-yl)acetate
- Packaging
- 100mg
- Price
- $157
- Updated
- 2021/12/16
- Product number
- CS-W020454
- Product name
- Ethyl2-(4-bromopyridin-2-yl)acetate
- Packaging
- 250mg
- Price
- $203
- Updated
- 2021/12/16
- Product number
- CS-W020454
- Product name
- Ethyl2-(4-bromopyridin-2-yl)acetate
- Packaging
- 1g
- Price
- $418
- Updated
- 2021/12/16
- Product number
- HCH0048584
- Product name
- ETHYL 2-(4-BROMOPYRIDIN-2-YL)ACETATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.8
- Updated
- 2021/12/16
Ethyl 2-(4-broMopyridin-2-yl)acetate Chemical Properties,Usage,Production
Synthesis
22282-99-1
105-58-8
1060814-91-6
General procedure for the synthesis of ethyl 2-(4-bromopyridin-2-yl)acetate from 4-bromo-2-methylpyridine and diethyl carbonate: Step 1: Synthesis of ethyl 2-(4-bromopyridin-2-yl)acetate Under nitrogen protection, 4-bromo-2-methylpyridine (2.00 g) and diethyl carbonate (1.8 mL) were dissolved in anhydrous tetrahydrofuran (30 mL) and cooled to -70°C. Lithium diisopropylammonium (2 mol/L in tetrahydrofuran/heptane/ethylbenzene, 3.00 mL) was slowly added and the reaction was stirred by keeping the temperature at -70°C for 1 hour. Subsequently, lithium diisopropylammonium (2 mol/L in tetrahydrofuran/heptane/ethylbenzene, 3.00 mL) was added again and stirring was continued at -70°C for 1 hour. Upon completion of the reaction, the reaction was quenched by the addition of water. The reaction mixture was extracted with ethyl acetate, the organic phases were combined, washed with saturated brine and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure and the resulting crude product was purified by silica gel column chromatography (eluent: cyclohexane/ethyl acetate, 95:5→1:1) to give ethyl 2-(4-bromopyridin-2-yl)acetate. Yield: 2.35 g (83% yield). LC (Method 3): tR = 2.86 min; MS (ESI+): m/z = 244/246 (Br)[M + H]+.
References
[1] Patent: WO2011/159760, 2011, A1. Location in patent: Page/Page column 73
[2] Patent: WO2018/106636, 2018, A1. Location in patent: Paragraph 00244
[3] Patent: WO2017/74833, 2017, A1. Location in patent: Page/Page column 61; 80; 81
Ethyl 2-(4-broMopyridin-2-yl)acetate Preparation Products And Raw materials
Raw materials
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View Lastest Price from Ethyl 2-(4-broMopyridin-2-yl)acetate manufacturers
- Product
- Ethyl 2-(4-broMopyridin-2-yl)acetate 1060814-91-6
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-14