BetaMethasone (hydrochloride)
- Product Name
- BetaMethasone (hydrochloride)
- CAS No.
- 956901-32-9
- Chemical Name
- BetaMethasone (hydrochloride)
- Synonyms
- BetaMethasone (hydrochloride)
- CBNumber
- CB82677080
- Molecular Formula
- C28H38ClFO7
- Formula Weight
- 541.0485232
- MOL File
- 956901-32-9.mol
BetaMethasone (hydrochloride) Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
BetaMethasone (hydrochloride) Chemical Properties,Usage,Production
Uses
Betamethasone hydrochloride is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone hydrochloride accelerates fetal lung maturation and induces gene expression and apoptosis[1][2][3][4].
in vivo
Betamethasone (0.48 mg; i.v.gtt for 48 h) decreases the hypercapnia-induced increase in CBF due to decreased cerebral vasodilatation[1].
Betamethasone (0.05 ml (1 mg/L); topical injection) ameliorates spinal nerve transection induced mechanical allodynia and thermal hyperalgesia, and reduces the activation of NF-κB and elevation of TNFα and IL-1β, and induces the expression of IL-10 in the rats brain[2].
| Animal Model: | Rambouillet-Colombia ewes bred on a single occasion are received hypercapnic challenges[1] |
| Dosage: | 0.48 mg |
| Administration: | Injected into the fetal jugular vein at a rate of 1 ml/h (10 μg betamethasone/h) and maintained over the next 48 h. |
| Result: | Decreased cerebral blood flow (CBF) in all brain regions measured except the hippocampus after 24 h of infusion. The reduction in CBF was diminished to about 25-30 % after 48 h of infusion. |
References
[1] Schwab M, et, al. Effects of betamethasone administration to the fetal sheep in late gestation on fetal cerebral blood flow. J Physiol. 2000 Nov 1;528(Pt 3):619-32. DOI:10.1111/j.1469-7793.2000.00619.x
[2] Xie W, et, al. Betamethasone affects cerebral expressions of NF-kappaB and cytokines that correlate with pain behavior in a rat model of neuropathy. Ann Clin Lab Sci. Winter 2006;36(1):39-46. PMID:16501235
[3] Kubin ME, et, al. Clinical Efficiency of Topical Calcipotriol/Betamethasone Treatment in Psoriasis Relies on Suppression of the Inflammatory TNFα - IL-23 - IL-17 Axis. Acta Derm Venereol. 2017 Apr 6;97(4):449-455. DOI:10.2340/00015555-2579
[4] Hofmann TH, et, al. Various glucocorticoids differ in their ability to induce gene expression, apoptosis and to repress NF-kappaB-dependent transcription. FEBS Lett. 1998 Dec 28;441(3):441-6. DOI:10.1016/s0014-5793(98)01609-3
BetaMethasone (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
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