MPLA (synthetic) Sterile Solution

Product Name: MPLA (synthetic) Sterile Solution
CAS No.: 1246298-63-4
Chemical Name: MPLA (synthetic) Sterile Solution
Synonyms: MPLA;GLA (PHAD);MPLA (PHAD);Glucopyranosyl lipid A;MPLA (PHAD^?);Glycopyranoside lipid A;Glucopyranosyl Lipid Adjuvant;MPLA (synthetic) Sterile Solution;Monophosphoryl Lipid A (Synthetic);Monophosphoryl Lipid A (Synthetic) (PHADTM)
CBNumber: CB82677868
Molecular Formula: C96H184N3O22P
Formula Weight: 1763.5
MOL File: 1246298-63-4.mol

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MPLA (synthetic) Sterile Solution Property

storage temp.: -20°C
solubility: DMSO: 1 mg/ml
form: Solid
color: White to off-white
Major Application: vaccine development

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H335May cause respiratory irritation

H371May cause damage to organs

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P309+P311IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25998
Product name: MPLA
Packaging: 500μg
Price: $83
Updated: 2021/12/16

Cayman Chemical

Product number: 25998
Product name: MPLA
Packaging: 1mg
Price: $158
Updated: 2021/12/16

Usbiological

Product number: 207277
Product name: MPLA
Packaging: 100ug
Price: $460
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 108240
Product name: LipidAmonophosphoryl-monoammoniumsalt
Packaging: 5mg
Price: $1500
Updated: 2021/12/16

Adipogen Life Sciences

Product number: AG-CU1-0002-C100
Product name: MPLA(synthetic)SterileSolution
Packaging: 100μg
Price: $280
Updated: 2021/12/16

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MPLA (synthetic) Sterile Solution Chemical Properties,Usage,Production

Uses

Monophosphoryl Lipid A, or GLA-SE, is a synthetic toll-like receptor 4 agonist which enhances T-cell responses to influenza vaccine in older adults.

Biological Activity

Monophosphoryl lipid A (MPLA) is a natural agonist for the toll-like receptor-4 (TLR4). It is useful as an adjuvant in immunization. MPLA is a safe prophylactic agent and has immunotherapeutic applications. MPLA used in vaccination improves B cell and T cell-mediated immunity.

in vivo

The generated Monophosphoryl lipid A has been shown to activate APC and to enhance the generation of both Th1- and Th2-specific immune response in mice^[2].

IC 50

TLR4

References

[1] N QURESHI. Monophosphoryl lipid A obtained from lipopolysaccharides of Salmonella minnesota R595. Purification of the dimethyl derivative by high performance liquid chromatography and complete structural determination.[J]. The Journal of Biological Chemistry, 1985, 260 9: 5271-5278.
[2] STACIE L LAMBERT. Molecular and cellular response profiles induced by the TLR4 agonist-based adjuvant Glucopyranosyl Lipid A.[J]. PLoS ONE, 2012: e51618. DOI: 10.1371/journal.pone.0051618
[3] MAURICIO A ARIAS. Glucopyranosyl Lipid Adjuvant (GLA), a Synthetic TLR4 agonist, promotes potent systemic and mucosal responses to intranasal immunization with HIVgp140.[J]. PLoS ONE, 2012: e41144. DOI: 10.1371/journal.pone.0041144
[4] SUSAN L BALDWIN. The importance of adjuvant formulation in the development of a tuberculosis vaccine.[J]. Journal of immunology, 2012, 188 5: 2189-2197. DOI: 10.4049/jimmunol.1102696

MPLA (synthetic) Sterile Solution Preparation Products And Raw materials

Raw materials

Preparation Products

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MPLA (synthetic) Sterile Solution Suppliers

China 46 United Kingdom 1 United States 4 Global 51

Shandong Xiya Chemical Co., Ltd

Tel: 13355009207 13355009207
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Hunan Hui Bai Shi Biotechnology Co., Ltd.

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Shanghai Aladdin Bio-Chem Technology Co.,LTD

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Shanghai AECOM Biotechnology Co. , Ltd.

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1246298-63-4, MPLA (synthetic) Sterile SolutionRelated Search:

MPLA (synthetic) Sterile Solution

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Monophosphoryl Lipid A (Synthetic) (PHADTM)

Glucopyranosyl Lipid Adjuvant

MPLA (PHAD)

MPLA

GLA (PHAD)

Monophosphoryl Lipid A (Synthetic)

Glucopyranosyl lipid A

MPLA (PHAD<sup>?</sup>)

MPLA (PHAD ?) Avanti Research? - A Croda Brand

1246298-63-4

C96H181N2O22PH3N