ChemicalBook > CAS DataBase List > 3-(3-Methoxyphenyl)-2-Methyl-N-(2-(thiazol-4-yl)-1H-benzo[d]iMidazol-5-yl)propanaMide hydrochloride

3-(3-Methoxyphenyl)-2-Methyl-N-(2-(thiazol-4-yl)-1H-benzo[d]iMidazol-5-yl)propanaMide hydrochloride

Product Name
3-(3-Methoxyphenyl)-2-Methyl-N-(2-(thiazol-4-yl)-1H-benzo[d]iMidazol-5-yl)propanaMide hydrochloride
CAS No.
1393748-80-5
Chemical Name
3-(3-Methoxyphenyl)-2-Methyl-N-(2-(thiazol-4-yl)-1H-benzo[d]iMidazol-5-yl)propanaMide hydrochloride
Synonyms
RY785;RY785, 10 mM in DMSO;Na+ channels,inhibit,RY785,Sodium Channel,RY-785,Na channels,RY 785,Inhibitor;Benzenepropanamide, 3-methoxy-α-methyl-N-[2-(4-thiazolyl)-1H-benzimidazol-6-yl]-;3-(3-methoxyphenyl)-2-methyl-N-[2-(1,3-thiazol-4-yl)-1H-1,3-benzodiazol-5-yl]propanamide;3-(3-Methoxyphenyl)-2-Methyl-N-(2-(thiazol-4-yl)-1H-benzo[d]iMidazol-5-yl)propanaMide hydrochloride
CBNumber
CB82678148
Molecular Formula
C21H20N4O2S
Formula Weight
392.47
MOL File
1393748-80-5.mol
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3-(3-Methoxyphenyl)-2-Methyl-N-(2-(thiazol-4-yl)-1H-benzo[d]iMidazol-5-yl)propanaMide hydrochloride Property

Density 
1.333±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 20 mg/ml; DMSO: 15 mg/ml; Ethanol: 15 mg/ml
form 
A crystalline solid
pka
9.81±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19813
Product name
RY785
Purity
≥98%
Packaging
500μg
Price
$39
Updated
2024/03/01
Cayman Chemical
Product number
19813
Product name
RY785
Purity
≥98%
Packaging
1mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
19813
Product name
RY785
Purity
≥98%
Packaging
5mg
Price
$302
Updated
2024/03/01
Cayman Chemical
Product number
19813
Product name
RY785
Purity
≥98%
Packaging
10mg
Price
$527
Updated
2024/03/01
AK Scientific
Product number
9680DW
Product name
3-(3-Methoxyphenyl)-2-methyl-N-[2-(1,3-thiazol-4-yl)-3H-benzimidazol-5-yl]propanamide
Packaging
10mg
Price
$685
Updated
2021/12/16
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3-(3-Methoxyphenyl)-2-Methyl-N-(2-(thiazol-4-yl)-1H-benzo[d]iMidazol-5-yl)propanaMide hydrochloride Chemical Properties,Usage,Production

Description

RY785 is a selective inhibitor of Kv2.1 voltage-gated potassium channels (IC50 = 0.05 μM) that does not affect Cav2 calcium channels. It displays over 100-fold selectivity for Kv2.1 over Cav1.2 (IC50 = 17 μM).

Uses

RY785 is a potent and selective voltage-gated potassium (KV2) channel inhibitor with an IC50 of 0.05 μM for KV2.2. RY785 has analgesic activity[1].

References

[1] Herrington J, et al. Identification of novel and selective Kv2 channel inhibitors. Mol Pharmacol. 2011 Dec;80(6):959-64. DOI:10.1124/mol.111.074831

3-(3-Methoxyphenyl)-2-Methyl-N-(2-(thiazol-4-yl)-1H-benzo[d]iMidazol-5-yl)propanaMide hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(3-Methoxyphenyl)-2-Methyl-N-(2-(thiazol-4-yl)-1H-benzo[d]iMidazol-5-yl)propanaMide hydrochloride Suppliers

China 39 United States 3 Global 42
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

1393748-80-5, 3-(3-Methoxyphenyl)-2-Methyl-N-(2-(thiazol-4-yl)-1H-benzo[d]iMidazol-5-yl)propanaMide hydrochlorideRelated Search:


  • 3-(3-Methoxyphenyl)-2-Methyl-N-(2-(thiazol-4-yl)-1H-benzo[d]iMidazol-5-yl)propanaMide hydrochloride
  • RY785
  • Benzenepropanamide, 3-methoxy-α-methyl-N-[2-(4-thiazolyl)-1H-benzimidazol-6-yl]-
  • Na+ channels,inhibit,RY785,Sodium Channel,RY-785,Na channels,RY 785,Inhibitor
  • 3-(3-methoxyphenyl)-2-methyl-N-[2-(1,3-thiazol-4-yl)-1H-1,3-benzodiazol-5-yl]propanamide
  • RY785, 10 mM in DMSO
  • 1393748-80-5