1-(α-D-ribofuranosyl)uracil

Product Name: 1-(α-D-ribofuranosyl)uracil
CAS No.: 3258-07-9
Chemical Name: 1-(α-D-ribofuranosyl)uracil
Synonyms: 0/9/58;alpha-Uridine;alpha-D-Uridine;1-(a-D-ribofuranosyl)uracil;1-(alpha-D-ribofuranosyl)uracil;1-(a-D-ribofuranosyl)uracil - [R93671];2,4(1H,3H)-Pyrimidinedione, 1-α-D-ribofuranosyl-;1-alpha-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione;alpha-D-Ribofuranoside, 2,4(1H,3H)-pyrimidinedione-1;1-[(2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furyl]pyrimidine-2,4(1H,3H)-dione
CBNumber: CB82681096
Molecular Formula: C9H12N2O6
Formula Weight: 244.2
MOL File: 3258-07-9.mol

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1-(α-D-ribofuranosyl)uracil Property

Density: 1.674±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 9.39±0.10(Predicted)
form: Solid
color: White to off-white
InChI: InChI=1/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8+/s3
InChIKey: DRTQHJPVMGBUCF-WAALHAOGNA-N
SMILES: O[C@@H]1[C@@H]([C@@H](CO)O[C@@H]1N1C=CC(=O)NC1=O)O |&1:1,2,3,7,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Ark Pharm

Product number: P000619751
Product name: 1-(a-D-ribofuranosyl)uracil
Purity: 95+%
Packaging: 100mg
Price: $125
Updated: 2021/12/16

Ark Pharm

Product number: P000619751
Product name: 1-(a-D-ribofuranosyl)uracil
Purity: 95+%
Packaging: 250mg
Price: $219
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: NUC0005177
Product name: 1-(ALPHA-D-RIBOFURANOSYL)URACIL
Purity: 95.00%
Packaging: 5MG
Price: $496.18
Updated: 2021/12/16

Ark Pharm

Product number: P000619751
Product name: 1-(a-D-ribofuranosyl)uracil
Purity: 95+%
Packaging: 1g
Price: $546
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NR31832
Product name: 1-(a-D-Ribofuranosyl)uracil
Packaging: 5G
Price: $1050
Updated: 2021/12/16

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1-(α-D-ribofuranosyl)uracil Chemical Properties,Usage,Production

Uses

1-(a-D-ribofuranosyl)uracil is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Synthesis

3258-15-9

3258-07-9

The general procedure for the synthesis of 1-((2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (Product A) from Compound D (CAS:3258-15-9) was as follows: 98 g of Compound D was dissolved in 500 mL of 0.1N hydrochloric acid solution at 20-25 °C The reaction was stirred at 20-25 °C for 24 h, during which the progress of the reaction was monitored by HPLC until the content of the remaining substance decreased to 0.21%. Upon completion of the reaction, the pH of the reaction system was adjusted to 7-8 using concentrated ammonia, followed by concentration under reduced pressure at 50±5°C until the volume was not reduced. Next, 500 mL of anhydrous acetonitrile was added to the concentrated residue and stirred at 70±5 °C until complete dissolution. Insoluble impurities were removed by filtration and the filtrate was crystallized by stirring at 0±5°C for 12 hours. The white solid product A was collected by filtration and analyzed by HPLC showing a purity of 99.92%. Finally, the product was blown dry at 45 °C for 24 h to give 71.8 g of the target compound.

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005

1-(α-D-ribofuranosyl)uracil Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(α-D-ribofuranosyl)uracil Suppliers

China 55 India 1 United Kingdom 1 United States 5 Global 62

Beijing Qinling Mountains Pharmaceutical Co., Ltd.

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View Lastest Price from 1-(α-D-ribofuranosyl)uracil manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1-(α-D-ribofuranosyl)uracil 3258-07-9
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2022-09-21

Shaanxi Dideu Medichem Co. Ltd

Product: 1-(α-D-ribofuranosyl)uracil 3258-07-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-11

3258-07-9, 1-(α-D-ribofuranosyl)uracilRelated Search:

1-(a-D-ribofuranosyl)uracil

alpha-D-Ribofuranoside, 2,4(1H,3H)-pyrimidinedione-1

alpha-D-Uridine

alpha-Uridine

1-(alpha-D-ribofuranosyl)uracil

1-alpha-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione

2,4(1H,3H)-Pyrimidinedione, 1-α-D-ribofuranosyl-

0/9/58

1-((2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

1-[(2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furyl]pyrimidine-2,4(1H,3H)-dione

1-(a-D-ribofuranosyl)uracil - [R93671]

(6aR,8R,9aR)-8-(2,6-diamino-9H-purin-9-yl)-2,2,4,4-tetrakis(propan-2-yl)-hexahydro-2H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9-ol

3258-07-9