PCI-32765 (RaceMate)

Product Name: PCI-32765 (RaceMate)
CAS No.: 936563-87-0
Chemical Name: PCI-32765 (RaceMate)
Synonyms: Ibrutinib Racemate;PCI-32765 (RaceMate);PCI-32765 racemate (Ibrutinib Racemate;IBRUTINIB RACEMATE (PCI-32765 RACEMATE);Bruton's Tyrosine Kinase Inhibitor III - CAS 936563-87-0 - Calbiochem;1-[3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one;2-Propen-1-one, 1-[3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-;1-(3-(4-Amino-3-(4-phenyloxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
CBNumber: CB82685933
Molecular Formula: C25H24N6O2
Formula Weight: 440.5
MOL File: 936563-87-0.mol

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PCI-32765 (RaceMate) Property

Boiling point:: 715.0±60.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: -20C
solubility: Soluble in DMSO
form: White crystalline solid
pka: 4.09±0.30(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-2438
Product name: IbrutinibRacemate
Purity: 95.57%
Packaging: 5mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-2438
Product name: IbrutinibRacemate
Purity: 95.57%
Packaging: 10mg
Price: $96
Updated: 2021/12/16

ChemScene

Product number: CS-2438
Product name: IbrutinibRacemate
Purity: 95.57%
Packaging: 50mg
Price: $240
Updated: 2021/12/16

ChemScene

Product number: CS-2438
Product name: IbrutinibRacemate
Purity: 95.57%
Packaging: 100mg
Price: $408
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0001255
Product name: EX-5965
Purity: 95.00%
Packaging: 100MG
Price: $589.4
Updated: 2021/12/16

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PCI-32765 (RaceMate) Chemical Properties,Usage,Production

Uses

Ibrutinib Racemate (PCI-32765 Racemate) is the racemate of Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor with IC50 value of 0.5 nM.

Definition

ChEBI: 1-[3-[4-amino-3-(4-phenoxyphenyl)-1-pyrazolo[3,4-d]pyrimidinyl]-1-piperidinyl]-2-propen-1-one is an aromatic ether.

Biological Activity

pci-32765 is an inhibitor of bruton tyrosine kinase (btk) with ic50 value of 0.5nm [1].pci-32765 is a covalent and irreversible inhibitor of btk through bonding to cys-481 in the atp binding domain. pci-32765 inhibits phosphorylation of btk in a b cells (ic50 of 11nm) as well as the downstream substrates phosphoinositide phospholipase cγ (plc γ) and erk in cell assays. pci-32765 has in vivo efficacy in b cell lymphoma. in cll cells, pci-32765 induces cells apoptosis through inhibiting the expression of bcr-dependent udp-glucose ceramide glucosyltransferase [1].pci-32765 is oral effective in vivo. it induces lymphocytosis during the first weeks of therapy in patients with cll. it is also efficacious in autoimmune disease. in the mrl-fas lupus model, pci-32765 inhibits collagen-induced arthritis as well as autoantibody production and development of kidney disease. it also diminished fcγriii-induced production of pro-inflammatory cytokines [1].

References

[1] burger ja, buggy jj. bruton tyrosine kinase inhibitor ibrutinib (pci-32765). leuk lymphoma. 2013 nov;54(11):2385-91.

PCI-32765 (RaceMate) Preparation Products And Raw materials

Raw materials

Preparation Products

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PCI-32765 (RaceMate) Suppliers

CHINA 26 United States 6 Global 32

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936563-87-0, PCI-32765 (RaceMate)Related Search:

PCI-32765 (RaceMate)

1-[3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one

1-(3-(4-Amino-3-(4-phenyloxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one

IBRUTINIB RACEMATE (PCI-32765 RACEMATE)

Bruton's Tyrosine Kinase Inhibitor III - CAS 936563-87-0 - Calbiochem

Ibrutinib Racemate

2-Propen-1-one, 1-[3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-

PCI-32765 racemate (Ibrutinib Racemate

936563-87-0