ChemicalBook > CAS DataBase List > 6-[(1-NaphthalenylMethyl)thio]-9H-purine

6-[(1-NaphthalenylMethyl)thio]-9H-purine

Product Name
6-[(1-NaphthalenylMethyl)thio]-9H-purine
CAS No.
313984-77-9
Chemical Name
6-[(1-NaphthalenylMethyl)thio]-9H-purine
Synonyms
PU 02;PU-02; PU02;6-[(1-NaphthalenylMethyl)thio]-9H-purine;6-((Naphthalen-1-ylmethyl)thio)-7H-purine;9H-Purine, 6-[(1-naphthalenylmethyl)thio]-;6-(Naphthalen-1-ylmethylsulfanyl)-7H-purine;5-HT Receptor,cyclin B1,cyclinD1,Inhibitor,Apoptosis,Serotonin Receptor,PU02,PU 02,HepG2,CDK4,5-hydroxytryptamine Receptor,inhibit
CBNumber
CB82686026
Molecular Formula
C16H12N4S
Formula Weight
292.36
MOL File
313984-77-9.mol
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6-[(1-NaphthalenylMethyl)thio]-9H-purine Property

storage temp. 
2-8°C
solubility 
Soluble to 100 mM in DMSO
form 
Powder
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
14312
Product name
PU 02
Purity
≥98%
Packaging
5mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
14312
Product name
PU 02
Purity
≥98%
Packaging
10mg
Price
$158
Updated
2024/03/01
Cayman Chemical
Product number
14312
Product name
PU 02
Purity
≥98%
Packaging
25mg
Price
$374
Updated
2024/03/01
Cayman Chemical
Product number
14312
Product name
PU 02
Purity
≥98%
Packaging
50mg
Price
$661
Updated
2024/03/01
Tocris
Product number
4700
Product name
PU02
Purity
≥97%(HPLC)
Packaging
10
Price
$95
Updated
2021/12/16
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6-[(1-NaphthalenylMethyl)thio]-9H-purine Chemical Properties,Usage,Production

Description

PU 02 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 with IC50 values ranging from 0.36 to 1.3 μM for human 5-HT3A, 5-HT3AB, 5-HT3AC, and 5-HT3AE in a FLIPR membrane potential assay using HEK293 cells expressing human recombinant receptors. It is selective for 5-HT3 over other Cys-loop containing receptors with IC50 values >100 μM for mouse, rat, and human nicotinic (nACh), human GABAA, and human glycine (Gly) receptors. PU 02 inhibits currents induced by 5-HT in COS-7 cells expressing human 5-HT3A (IC50 = 0.49 μM). PU 02 also reduces growth of HepG2 cells in a dose-dependent manner via induction of cell cycle arrest at the G2/M phase and apoptosis.

6-[(1-NaphthalenylMethyl)thio]-9H-purine Preparation Products And Raw materials

Raw materials

Preparation Products

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6-[(1-NaphthalenylMethyl)thio]-9H-purine Suppliers

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313984-77-9, 6-[(1-NaphthalenylMethyl)thio]-9H-purineRelated Search:


  • 6-[(1-NaphthalenylMethyl)thio]-9H-purine
  • PU 02
  • 6-((Naphthalen-1-ylmethyl)thio)-7H-purine
  • 6-(Naphthalen-1-ylmethylsulfanyl)-7H-purine
  • PU-02; PU02
  • 9H-Purine, 6-[(1-naphthalenylmethyl)thio]-
  • 5-HT Receptor,cyclin B1,cyclinD1,Inhibitor,Apoptosis,Serotonin Receptor,PU02,PU 02,HepG2,CDK4,5-hydroxytryptamine Receptor,inhibit
  • 313984-77-9