5-Nitro-2,3-dihydro-1-benzofuran
- Product Name
- 5-Nitro-2,3-dihydro-1-benzofuran
- CAS No.
- 17403-47-3
- Chemical Name
- 5-Nitro-2,3-dihydro-1-benzofuran
- Synonyms
- Anaprazole Impurity 1;2,3-Dihydro-5-nitrobenzofuran;5-Nitro-2,3-dihydrobenzofuran;Benzofuran, 2,3-dihydro-5-nitro-;5-Nitro-2,3-dihydro-1-benzofuran
- CBNumber
- CB82692940
- Molecular Formula
- C8H7NO3
- Formula Weight
- 165.15
- MOL File
- 17403-47-3.mol
5-Nitro-2,3-dihydro-1-benzofuran Property
- Boiling point:
- 292.3±29.0 °C(Predicted)
- Density
- 1.360±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Appearance
- Light yellow to yellow Solid
Safety
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-B1173
- Product name
- 2,3-Dihydro-5-nitrobenzofuran
- Packaging
- 1g
- Price
- $64
- Updated
- 2021/12/16
- Product number
- 5618AD
- Product name
- 5-Nitro-2,3-dihydro-1-benzofuran
- Packaging
- 10g
- Price
- $162
- Updated
- 2021/12/16
- Product number
- 4H54-1-J3
- Product name
- 5-Nitro-2,3-dihydro-1-benzofuran
- Packaging
- 1g
- Price
- $212
- Updated
- 2021/12/16
- Product number
- 088857
- Product name
- 5-Nitro-2,3-dihydro-1-benzofuran
- Packaging
- 1g
- Price
- $286
- Updated
- 2021/12/16
- Product number
- 4H54-1-J3
- Product name
- 5-Nitro-2,3-dihydro-1-benzofuran
- Packaging
- 5G
- Price
- $792
- Updated
- 2021/12/16
5-Nitro-2,3-dihydro-1-benzofuran Chemical Properties,Usage,Production
Synthesis
496-16-2
17403-47-3
Step 1: Preparation of 5-nitro-2,3-dihydrobenzofuran 2,3-Dihydrobenzofuran (36 g, 0.3 mol) was dissolved in glacial acetic acid (100 mL) and heated to 65°C. The reaction temperature was maintained at a constant temperature. Under constant temperature, concentrated nitric acid (25 mL, 0.36 mol) was slowly added dropwise, and the reaction temperature was controlled to be maintained between 65-75°C. The reaction was carried out at a constant temperature. After the dropwise addition was completed, the reaction mixture was continued to be stirred for 0.5 hours. After completion of the reaction, the mixture was cooled to room temperature, the solid product was separated by filtration, washed with water to remove the residual acid, and dried to give 5-nitro-2,3-dihydrobenzofuran (22 g, 44.4% yield).
References
[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 13, p. 5579 - 5601
[2] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 13, p. 3821 - 3830
[3] Patent: EP2532665, 2012, A1. Location in patent: Page/Page column 41
[4] Patent: WO2003/82787, 2003, A1. Location in patent: Page/Page column 138-139
[5] Journal of Medicinal Chemistry, 2010, vol. 53, # 18, p. 6681 - 6698
5-Nitro-2,3-dihydro-1-benzofuran Preparation Products And Raw materials
Raw materials
Preparation Products
5-Nitro-2,3-dihydro-1-benzofuran Suppliers
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- tp@aladdinsci.com
- Country
- United States
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View Lastest Price from 5-Nitro-2,3-dihydro-1-benzofuran manufacturers
- Product
- 5-Nitro-2,3-dihydro-1-benzofuran 17403-47-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-14
- Product
- 5-Nitro-2,3-dihydro-1-benzofuran 17403-47-3
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08