1-(Oxetan-3-yl)piperazine

Product Name: 1-(Oxetan-3-yl)piperazine
CAS No.: 1254115-23-5
Chemical Name: 1-(Oxetan-3-yl)piperazine
Synonyms: 1-(3-Oxetanyl)-piperazine;1-(Oxetan-3-yl)piperazine;Piperazine, 1-(3-oxetanyl)-;1-(OXETAN-3-YL)PIPERAZINE 1G
CBNumber: CB82697172
Molecular Formula: C7H14N2O
Formula Weight: 142.2
MOL File: 1254115-23-5.mol

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1-(Oxetan-3-yl)piperazine Property

Boiling point:: 227.2±25.0 °C(Predicted)
Density: 1.100±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 9.03±0.10(Predicted)
form: liquid
color: Light yellow
InChI: InChI=1S/C7H14N2O/c1-3-9(4-2-8-1)7-5-10-6-7/h7-8H,1-6H2
InChIKey: AOYSLJHKVBSXRU-UHFFFAOYSA-N
SMILES: N1(C2COC2)CCNCC1

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: E588813
Product name: 1-(Oxetan-3-yl)piperazine
Packaging: 500mg
Price: $130
Updated: 2021/12/16

ChemScene

Product number: CS-W007243
Product name: 1-(Oxetan-3-yl)piperazine
Purity: 99.67%
Packaging: 5g
Price: $98
Updated: 2021/12/16

Matrix Scientific

Product number: 113363
Product name: 1-(Oxetan-3-yl)piperazine
Packaging: 1g
Price: $145
Updated: 2021/12/16

ChemScene

Product number: CS-W007243
Product name: 1-(Oxetan-3-yl)piperazine
Purity: 99.67%
Packaging: 10g
Price: $146
Updated: 2021/12/16

ChemScene

Product number: CS-W007243
Product name: 1-(Oxetan-3-yl)piperazine
Purity: 99.67%
Packaging: 25g
Price: $155
Updated: 2021/12/16

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1-(Oxetan-3-yl)piperazine Chemical Properties,Usage,Production

Synthesis

1254115-22-4

1254115-23-5

General procedure for the synthesis of 1-(oxetan-3-yl)piperazine from benzyl 4-(oxetan-3-yl)piperazine-1-carboxylate: in a 1L three-necked flask, palladium hydroxide (Pd(OH)2, 1.661 g, 2.366 mmol) was added under nitrogen protection. Methanol (MeOH, 130.8 mL) and ethyl acetate (EtOAc, 261.6 mL) were then added and the mixture was degassed by vacuum/nitrogen cycles (3 times). Then benzyl 4-(oxetan-3-yl)piperazine-1-carboxylate (32.7 g, 118.3 mmol) was added and the reaction mixture was stirred overnight under hydrogen atmosphere. After completion of the reaction, the mixture was filtered through a pad of diatomaceous earth and washed sequentially with ethyl acetate and methanol. The filtrate was concentrated under reduced pressure to afford the target product 1-(oxetan-3-yl)piperazine (25) as an orange oil (8.1 g, quantitative yield). The structure of the product was confirmed by 1H NMR (500 MHz, DMSO-d6) with the following characteristic peaks: δ 4.51 (t, 2H), 4.41 (t, 2H), 3.36-3.30 (masked signal, 1H), 2.69 (t, 4H) and 2.14 (br s, 4H).

References

[1] Patent: WO2014/89379, 2014, A1. Location in patent: Paragraph 00443
[2] Patent: US2015/158872, 2015, A1. Location in patent: Paragraph 0511; 0514
[3] Patent: US2012/277205, 2012, A1. Location in patent: Page/Page column 31-32
[4] Patent: WO2012/146318, 2012, A1. Location in patent: Page/Page column 70

1-(Oxetan-3-yl)piperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(Oxetan-3-yl)piperazine Suppliers

China 111 India 3 United Kingdom 1 United States 6 Global 121

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View Lastest Price from 1-(Oxetan-3-yl)piperazine manufacturers

Career Henan Chemical Co

Product: 1-(Oxetan-3-yl)piperazine 1254115-23-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-26

1254115-23-5, 1-(Oxetan-3-yl)piperazineRelated Search:

1-(Oxetan-3-yl)piperazine

1-(OXETAN-3-YL)PIPERAZINE 1G

1-(3-Oxetanyl)-piperazine

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1254115-23-5