6-Oxaspiro[2.5]octane-1-carboxylic acid

Product Name: 6-Oxaspiro[2.5]octane-1-carboxylic acid
CAS No.: 909406-73-1
Chemical Name: 6-Oxaspiro[2.5]octane-1-carboxylic acid
Synonyms: 6-Oxaspiro[2.5]octane-1-carboxylic acid;6-Oxaspiro[2.5]octane-1-carboxylic acid - X11552
CBNumber: CB82698447
Molecular Formula: C8H12O3
Formula Weight: 156.18
MOL File: 909406-73-1.mol

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6-Oxaspiro[2.5]octane-1-carboxylic acid Property

Boiling point:: 312.4±35.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 4.66±0.20(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C8H12O3/c9-7(10)6-5-8(6)1-3-11-4-2-8/h6H,1-5H2,(H,9,10)
InChIKey: FGFLMSPWCDFJRM-UHFFFAOYSA-N
SMILES: C1(C(O)=O)C2(CCOCC2)C1

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Safety

WGK Germany: WGK 3
HS Code: 2932990090
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: O845205
Product name: 6-Oxaspiro[2.5]octane-1-carboxylicAcid
Packaging: 50mg
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2H21-1-46
Product name: 6-Oxaspiro[2.5]octane-1-carboxylicacid
Packaging: 1g
Price: $375
Updated: 2021/12/16

AK Scientific

Product number: 5870DK
Product name: 6-Oxaspiro[2.5]octane-1-carboxylicacid
Packaging: 500mg
Price: $394
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM1052021
Product name: 6-OXASPIRO[2.5]OCTANE-1-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $457.66
Updated: 2021/12/16

AK Scientific

Product number: 5870DK
Product name: 6-Oxaspiro[2.5]octane-1-carboxylicacid
Packaging: 2.5g
Price: $927
Updated: 2021/12/16

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6-Oxaspiro[2.5]octane-1-carboxylic acid Chemical Properties,Usage,Production

Synthesis

909406-74-2

909406-73-1

General procedure for the synthesis of 6-oxaspiro[2.5]octane-1-carboxylic acid from ethyl 6-oxaspiro[2.5]octane-1-carboxylate: to a solvent mixture (THF:MeOH:H2O = 2:1:1, total volume 6 mL) containing ester B-6a (50 mg, 0.271 mmol) was added LiOH (65.0 mg, 2.71 mmol). The reaction mixture was stirred at 0 °C and subsequently brought to room temperature and continued stirring for 12 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and the pH was adjusted with 1.5 N HCl solution to about 3. Next, the reaction mixture was extracted with DCM (2 x 50 mL), the organic phases were combined and washed with brine (25 mL), dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure to afford the target product Cap B-6 (35 mg) as a colorless liquid. The product was characterized by 1H NMR (CDCl3, δ=7.26 ppm, 300 MHz): δ3.83-3.68 (m, 4H), 1.85-1.81 (m, 2H), 1.62-1.42 (m, 3H), 1.21 (t, J=6.4 Hz, 1H), 1.07-1.01 (m, 1H).

References

[1] Patent: WO2007/31558, 2007, A1. Location in patent: Page/Page column 40
[2] Patent: EP1958666, 2008, A1
[3] Patent: WO2006/95020, 2006, A1. Location in patent: Page/Page column 30
[4] Patent: WO2015/5901, 2015, A1. Location in patent: Page/Page column 625; 626

6-Oxaspiro[2.5]octane-1-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Oxaspiro[2.5]octane-1-carboxylic acid Suppliers

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909406-73-1, 6-Oxaspiro[2.5]octane-1-carboxylic acidRelated Search:

6-Oxaspiro[2.5]octane-1-carboxylic acid

6-Oxaspiro[2.5]octane-1-carboxylic acid - X11552

909406-73-1