trans-tert-Butyl 3-hydroxy-2,2,4,4-(tetraMethyl)cyclobutylcarbaMate
Application- Product Name
- trans-tert-Butyl 3-hydroxy-2,2,4,4-(tetraMethyl)cyclobutylcarbaMate
- CAS No.
- 1338812-41-1
- Chemical Name
- trans-tert-Butyl 3-hydroxy-2,2,4,4-(tetraMethyl)cyclobutylcarbaMate
- Synonyms
- NON-FLUORINE;trans-3-(Boc-amino)-2,2,4,4-tetramethyl-cyclobutanol;tert-Butyl (trans-3-hydroxy-2,2,4,4-tetramethylcyclobutyl)carbamate;trans-tert-Butyl 3-hydroxy-2,2,4,4-(tetraMethyl)cyclobutylcarbaMate;tert-butyl ((1r,3r)-3-hydroxy-2,2,4,4-tetramethylcyclobutyl)carbamate;tert-butyl N-[(1r,3r)-3-hydroxy-2,2,4,4-tetramethylcyclobutyl]carbamate;trans-tert-Butyl ((1r,3r)-3-hydroxy-2,2,4,4-tetramethylcyclobutyl)carbamate;trans-tert-Butyl 3-hydroxy-2,2,4,4-(tetramethyl)cyclobutylcarbamate - B14549;trans-tert-Butyl 3-hydroxy-2,2,4,4-(tetraMethyl)cyclobutylcarbaMate ISO 9001：2015 REACH;Carbamic acid, N-(trans-3-hydroxy-2,2,4,4-tetramethylcyclobutyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB82704865
- Molecular Formula
- C13H25NO3
- Formula Weight
- 243.34
- MOL File
- 1338812-41-1.mol
trans-tert-Butyl 3-hydroxy-2,2,4,4-(tetraMethyl)cyclobutylcarbaMate Property
- Boiling point:
- 326.7±31.0 °C(Predicted)
- Density
- 1.03±0.1 g/cm3(Predicted)
- storage temp.
- Store at 0-8 °C
- pka
- 12.28±0.70(Predicted)
- Appearance
- white solid
- InChI
- InChI=1S/C13H25NO3/c1-11(2,3)17-10(16)14-8-12(4,5)9(15)13(8,6)7/h8-9,15H,1-7H3,(H,14,16)/t8-,9-
- InChIKey
- BRCDKHQTJYOCIF-KYZUINATSA-N
- SMILES
- C(OC(C)(C)C)(=O)N[C@@H]1C(C)(C)[C@@H](O)C1(C)C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0054757
- Product name
- trans-tert-Butyl((1r,3r)-3-hydroxy-2,2,4,4-tetramethylcyclobutyl)carbamate
- Purity
- >97.0%
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CS-0054757
- Product name
- trans-tert-Butyl((1r,3r)-3-hydroxy-2,2,4,4-tetramethylcyclobutyl)carbamate
- Purity
- >97.0%
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 8353DM
- Product name
- cis-Tert-butyl3-hydroxy-2,2,4,4-(tetramethyl)cyclobutylcarbamate
- Packaging
- 25mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- CS-0054757
- Product name
- trans-tert-Butyl((1r,3r)-3-hydroxy-2,2,4,4-tetramethylcyclobutyl)carbamate
- Purity
- >97.0%
- Packaging
- 1g
- Price
- $420
- Updated
- 2021/12/16
- Product number
- CHM1051618
- Product name
- TRANS-TERT-BUTYL-3-HYDROXY-2,2,4,4-(TETRAMETHYL)CYCLOBUTYLCARBAMATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.8
- Updated
- 2021/12/16
trans-tert-Butyl 3-hydroxy-2,2,4,4-(tetraMethyl)cyclobutylcarbaMate Chemical Properties,Usage,Production
Application
3-Hydroxy-2,2,4,4-(tetramethoxy)cyclobutylcarbamate tert-butyl ester is a pharmaceutical intermediate, and there are literature reports that it can be used to prepare a novel androgen receptor antagonist.
Synthesis
Suspend (1r,3r)-3-amino-2,2,4,4-tetramethylcyclobutanol (79.6 mmol) in dioxane (240 ml). Add a solution of K2CO3 (164 mmol) in H2O (80 ml) dropwise to the reaction mixture at 0 °C. Stir the resulting mixture overnight at room temperature. Monitor the completion of reaction by TLC (2:1 Petroleum ether/EtOAc). Evaporate the reaction mixture. Dilute the residue with water (200 ml) and CH2Cl2 (400 ml). Separate the organic layer. Extract the aqueous layer with CH2Cl2 (100 ml x 3). Wash the combined organic layers with brine (100 ml). Dry the combined organic layers over Na2SO4. Filter the combined organic layers. Evaporate the combined organic layers. Purify the crude product by column chromatography (10:1 Petroleum ether/EtOAc) to obtain the trans-tert-Butyl 3-hydroxy-2,2,4,4-(tetraMethyl)cyclobutylcarbaMate.
References
[1] CHUANGXING GUO*. Discovery of Aryloxy Tetramethylcyclobutanes as Novel Androgen Receptor Antagonists[J]. Journal of Medicinal Chemistry, 2011, 54 21: 7693-7704. DOI:10.1021/jm201059s.
trans-tert-Butyl 3-hydroxy-2,2,4,4-(tetraMethyl)cyclobutylcarbaMate Preparation Products And Raw materials
Raw materials
Preparation Products
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